Inhibition of hepatitis C virus (HCV) RNA polymerase by DNA aptamers: Mechanism of inhibition of in vitro RNA synthesis and effect on HCV-infected cells

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 6, 2008, Pages 2097-2110

  Bellecave, Pantxika ^a,c   Cazenave, Christian ^a,c   Rumi, Julie ^a,c   Staedel, Cathy ^b,c   Cosnefroy, Ophélie ^a,c   Andreola, Marie Line ^a,c   Ventura, Michel ^a,c   Tarrago Litvak, Laura ^a,c   Astier Gin, Thérèse ^a,c,d  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b INSERM U869   (France)

^c NONE   (France)

^d University Victor Segalen   (France)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; DNA; RNA POLYMERASE; VIRUS RNA;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA STRUCTURE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA STRUCTURE; RNA SYNTHESIS; TREATMENT PLANNING; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS STRAIN;

APTAMERS, NUCLEOTIDE; CELL LINE; CELL LINE, TUMOR; HEPACIVIRUS; HUMANS; RNA REPLICASE; RNA, VIRAL; SELEX APTAMER TECHNIQUE; TRANSFECTION; VIRAL NONSTRUCTURAL PROTEINS; VIRION; VIRUS REPLICATION;

EID: 44449111650     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01227-07     Document Type: Article

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