Context Processing in Schizotypal Personality Disorder: Evidence of Specificity of Impairment to the Schizophrenia Spectrum

Journal of Abnormal Psychology

Volumn 117, Issue 2, 2008, Pages 342-354

  McClure, Margaret M ^a,b   Barch, Deanna M ^c   Flory, Janine D ^b,d   Harvey, Philip D ^a,b   Siever, Larry J ^a,b  

^a Education and Clinical Center   (United States)

^b Sinai School of Medicine   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

cognition; context processing; personality disorders; schizophrenia spectrum; schizotypal personality

Indexed keywords

ACCURACY; ADULT; ARTICLE; COGNITION; CONTROLLED STUDY; DISORIENTATION; ERROR; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PERSONALITY DISORDER; PSYCHOLOGIC TEST; SCHIZOPHRENIA; SCHIZOTYPAL PERSONALITY DISORDER; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; SYMPTOM; TASK PERFORMANCE; WORKING MEMORY;

EID: 44449106741     PISSN: 0021843X     EISSN: None     Source Type: Journal    
DOI: 10.1037/0021-843X.117.2.342     Document Type: Article

References (68)

1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. (1994), Author, Washington, DC
2. Barch D.M., Braver T.S., Cohen J.D., and Servan-Screiber D. Context processing deficits in schizophrenia. Archives of General Psychiatry 55 (1998) 187-188
3. Barch D.M., and Carter C.S. Amphetamine improves cognitive function in medicated individuals with schizophrenia and in healthy volunteers. Schizophrenia Research 77 (2005) 43-58
4. Barch D.M., Carter C.S., Braver T.S., McDonald A., Sabb F.W., Noll D.C., et al. Selective deficits in prefrontal cortex regions in medication naive schizophrenia patients. Archives of General Psychiatry 50 (2001) 280-288
5. Barch D.M., Carter C.S., MacDonald III A.W., Braver T.S., and Cohen J.D. Context-processing deficits in schizophrenia: Diagnostic specificity, 4-week course, and relationships to clinical symptoms. Journal of Abnormal Psychology 112 (2003) 132-143
6. Barch D.M., Csernansky J., Conturo T., Snyder A.Z., and Ollinger J. Working and long-term memory deficits in schizophrenia. Is there a common underlying prefrontal mechanism?. Journal of Abnormal Psychology 111 (2002) 478-494
7. Barch D.M., Mitropoulou V., Harvey P.D., New A.S., Silverman J.S., and Siever L.J. Context-processing deficits in schizotypal personality disorder. Journal of Abnormal Psychology 113 (2004) 556-568
8. Beech A., Baylic G.C., Smithson P., and Claridge G. Individual differences in schizotypy as reflected in measures of cognitive inhibition. British Journal of Clinical Psychology 28 (1989) 117-129
9. Bergman A.J., Harvey P.D., Mitropoulou V., Aronson A., Marder D., Silverman J., et al. The factor structure of schizotypal symptoms in a clinical population. Schizophrenia Bulletin 22 (1996) 501-509
10. Bergman A.J., Harvey P.D., Roitman S.L., Mohs R.C., Marder D., Silverman J.M., et al. Verbal learning and memory in schizotypal personality disorder. Schizophrenia Bulletin 24 (1998) 635-641
11. Bowie C.R., and Harvey P.D. Cognition in schizophrenia: Impairments, determinants, and functional importance. Psychiatric Clinics of North America 28 (2005) 613-633
12. Brambilla P., MacDonald III A.W., Sassi R.B., Johnson M.K., Mallinger A.G., Carter C.S., and Soares J.C. Context processing in bipolar disorder patients. Bipolar Disorders 9 (2007) 230-237
13. Braver T.S., Barch D.M., and Cohen J.D. Cognition and control in schizophrenia: A computational model of dopamine and prefrontal function. Biological Psychiatry 46 (1999) 312-328
14. Braver T.S., and Cohen J.D. Dopamine, cognitive control, and schizophrenia: The gating model. Progress in Brain Research 121 (1999) 327-349
15. Braver T.S., Cohen J.D., Nystrom L.E., Jonides J., Smith E.E., and Noll D.C. A parametric study of prefrontal cortex involvement in human working memory. NeuroImage 5 (1997) 49-62
16. Burton S.C. Strategies for improving adherence to second-generation antipsychotics in patients with schizophrenia by increasing ease of use. Journal of Psychiatric Practice 11 (2005) 369-378
17. Cadenhead K.S., Perry W., Shafer K., and Braff D.L. Cognitive functions in schizotypal personality disorder. Schizophrenia Research 37 (1999) 123-132
18. Callicott J.H., Bertolino A., Mattay V.S., Langheim F.J., Duyn J., Coppola R., et al. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cerebral Cortex 10 (2000) 1078-1092
19. Callicott J.H., Egan M.F., Mattay V.S., Bertolino A., Bone A.D., Verchinski B., et al. Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitive intact siblings of patients with schizophrenia. American Journal of Psychiatry 160 (2003) 709-719
20. Casey B.J., Cohen J.D., Jezzard P., Turner R., Noll D.C., Trainor R., et al. Activation of prefrontal cortex in children during a non-spatial working memory task with functional MRI. NeuroImage 2 (1995) 221-229
21. Chen E.Y., Hui C.L., Dunn E.L., Lien Y.J., Chang Y.H., and Hwu H.G. A prospective 3-year longitudinal study of cognitive predictors of relapse in first-episode schizophrenia patients. Schizophrenia Research 77 (1998) 99-104
22. Cohen J.D., Barch D.M., Carter C., and Servan-Schreiber D. Context-processing deficits in schizophrenia: Converging evidence from three theoretically motivated cognitive tasks. Journal of Abnormal Psychology 108 (1999) 120-133
23. Cohen J.D., Braver T.S., Perlstein W.M., Jonides J., Smith E.E., and Noll D.C. Temporal dynamics of cortical activity in verbal working memory. NeuroImage 3 (1996) S537
24. Cohen J.D., MacWhinney B., Flatt M.R., and Provost J. PsyScope: A new graphic interactive environment for designing psychology experiments. Behavioral Research Methods, Instruments & Computers 25 (1993) 257-271
25. Cohen J.D., and Servan-Schreiber D. Context, cortex and dopamine: A connectionist approach to behavior and biology in schizophrenia. Psychological Review 99 (1992) 45-77
26. Davidson M., Harvey P.D., Powchik P., Parella M., White L., Knobler H.Y., et al. Severity of symptoms in geriatric chronic schizophrenic patients. American Journal of Psychiatry 152 (1995) 197-207
27. deJong P.F., and Olson R.K. Early predictors of letter knowledge. Journal of Experimental Child Psychology 88 (2004) 254-273
28. Diforio D., Walker E., and Kestler L.P. Executive function in adolescents with schizotypal personality disorder. Schizophrenia Research 42 (2000) 125-134
29. Egan M.F., Goldberg T.E., Kolachana B.S., Callicott J.H., Mazzantu C.M., Straub R.E., et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Sciences, USA 98 (2001) 6917-6922
30. Farmer C.M., O'Donnell B.F., Niznikiewicz M.A., Voglmaier M.M., McCarley R.W., and Shenton M.E. Visual perception and working memory in schizotypal personality disorder. American Journal of Psychiatry 157 (2000) 781-786
31. First M.B., Spitzer R.L., Gibbon M., and Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders-Patient Edition (SCID-I/P, Version 2.0) (1995), New York State Psychiatric Institute, New York
32. Friedman J.I., Temporini H., and Davis K.L. Pharmacological strategies for augmenting cognitive performance in schizophrenia. Biological Psychiatry 45 (1999) 1-16
33. Gathercole S.E., Tiffany C., Briscoe J., Thorn A., and ALSPAC Team. Developmental consequences of poor phonological short-term memory function in childhood: A longitudinal study. Journal of Child Psychology & Psychiatry 46 (2005) 598-611
34. Green M.F. Cognitive impairment and functional outcome in schizophrenia and bipolar disorder. Journal of Clinical Psychiatry 67 (2006) 3-8
35. Green M.F., Waldron J.H., and Coltheart M. Emotional context processing is impaired in schizophrenia. Cognitive Neuropsychiatry 12 (2007) 259-280
36. Guy W. Clinical Global Impressions. ECDEU assessment manual for psychopharmacology: Revised (1976), National Institute of Mental Health, Rockville, MD 218-222
37. Harvey P.D., Reichenberg A., Romero M., Granholm E., and Siever L.J. Dual-task information processing in schizotypal personality disorder: Evidence of impaired processing capacity. Neuropsychology 20 (2006) 453-460
38. Heaton R.K., Gladsjo J.A., Palmer B.W., Kuck J., Heaton R.K., and Jeste D.V. Stability and course of neuropsychological deficits in schizophrenia. Archives of General Psychiatry 58 (2001) 24-32
39. Heinrichs R.W. The primacy of cognition in schizophrenia. American Psychologist 60 (2005) 229-242
40. Kirrane R.M., Mitropoulou V., Nunn M., New A.S., Harvey P.D., Schopick F., et al. Effects of amphetamine on visuospatial working memory performance in schizophrenia spectrum personality disorder. Neuropsychopharmacology 22 (2000) 14-18
41. Koenigsberg H.W., Buchsbaum M.S., Buchsbaum B.R., Schneiderman J.S., Tang C.Y., New A., et al. Functional MRI of visuospatial working memory in schizotypal personality disorder: A region-of-interest analysis. Psychological Medicine 35 (2005) 1019-1030
42. Lenzenweger M.F. Schizotaxia, schizotypy, and schizophrenia: Paul Meehl's blueprint for the experimental psychopathology and genetics of schizophrenia. Journal of Abnormal Psychology 115 (2006) 195-200
43. MacDonald III A.W., Carter C.S., Kerns J.G., Ursu S., Barch D.M., Holmes A.J., et al. Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis. American Journal of Psychiatry 162 (2005) 475-484
44. MacDonald III A.W., Pogue-Geile M.F., Johnson M.K., and Carter C.S. A specific deficit in context processing in the unaffected siblings of patients with schizophrenia. Archives of General Psychiatry 60 (2003) 57-65
45. Menon V., Anagnoson R.T., Mathalon D.H., Glover G.H., and Pfefferbaum A. Functional neuroanatomy of auditory working memory in schizophrenia: Relation to positive and negative symptoms. NeuroImage 13 (2001) 433-446
46. Mishara A.L., and Goldberg T.E. A meta-analysis and critical review of the effects of conventional neuroleptic treatment on cognition in schizophrenia: Opening a closed book. Biological Psychiatry 55 (2004) 1013-1022
47. Mitropoulou V., Harvey P.D., Zegarelli G., New A.S., Silverman J.M., and Siever L.J. Neuropsychological performance in schizotypal personality disorder: Importance of working memory. American Journal of Psychiatry 162 (2005) 1896-1903
48. Moriarty P.J., Harvey P.D., Granholm E., Mitropoulou V., and Siever L.J. Information processing capacity in schizotypal personality disorder: Evidence from a study of dual-task information processing. Journal of Clinical and Experimental Neuropsychology 25 (2003) 335-347
49. Moritz S., and Mass R. Reduced cognitive inhibition in schizotypy. British Journal of Clinical Psychology 36 (1997) 365-376
50. Niznikiewicz M.A., Shenton M.E., Voglmaier M., Nestor P.G., Dickey C.C., Rhoads R., et al. Semantic dysfunction in woman with schizotypal personality disorder. American Journal of Psychiatry 159 (2002) 1767-1774
51. Niznikiewicz M.A., Voglmaier M., Shenton M.E., Seidman L.J., Dickey C.C., Rhoads R., et al. Electrophysiological correlates of language processing in schizotypal personality disorder. American Journal of Psychiatry 156 (1999) 1052-1058
52. Nuechterlein K.H. Vigilance in schizophrenia and related disorders. In: Steinhauer S.R., Gruzelier J.H., and Zubin J. (Eds). Handbook of schizophrenia 5 (1991), Elsevier, Amsterdam 397-433
53. Overall J.E., and Gorham D.R. The Brief Psychiatric Rating Scale. Psychological Reports 10 (1962) 799-812
54. Park S., Holzman P.S., and Lenzenweger M.F. Individual differences in spatial working memory in relation to schizotypy. Journal of Abnormal Psychology 104 (1995) 355-363
55. Perlstein W.H., Carter C.S., Noll D.C., and Cohen J.D. Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia. American Journal of Psychiatry 158 (2001) 1105-1113
56. Pfohl B., Blum N., and Zimmerman M. Structured Interview for DSM-IV Personality (SIDP-IV) (1995), University of Iowa, College of Medicine, Iowa City
57. Prouteau A., Verdoux H., Briand C., Lesage A., Lalonde P., Nichole L., et al. Cognitive predictors of psychosocial functioning outcome in schizophrenia: A follow-up study of subjects participating in a rehabilitation program. Schizophrenia Research 77 (2005) 343-353
58. Roitman S.E., Cornblatt B.A., Bergman A., Obuchowski M., Mitropoulou V., Keefe R.S., et al. Attentional functioning in schizotypal personality disorder. American Journal of Psychiatry 154 (1997) 655-660
59. Roitman S.E., Mitropoulou V., Keefe R.S., Silverman J.M., Serby M., Harvey P.D., et al. Visuospatial working memory in schizotypal personality disorder patients. Schizophrenia Research 41 (2000) 447-455
60. Saykin A.J., Shtasel D.L., Gur R.E., Kester D.B., Mozley L.H., Stafiniak P., et al. Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia. Archives of General Psychiatry 51 (1994) 124-131
61. Siegel B.V., Trestman R.L., O'Faithbheartaigh S., Mitropoulou V., Amin F., Kirrane R.M., et al. D-amphetamine challenge effects on Wisconsin Card Sort Test performance in schizotypal personality disorder. Schizophrenia Research 20 (1996) 29-32
62. Siever L.J. Biological markers in schizotypal personality disorder. Schizophrenia Bulletin 11 (1995) 564-574
63. Siever L.J., and Davis K.L. A psychobiological perspective on the personality disorders. American Journal of Psychiatry 148 (1991) 1647-1658
64. Silver H., Feldman P., Bilker W., and Gur R.C. Working memory deficit as a core neuropsychological dysfunction in schizophrenia. American Journal of Psychiatry 160 (2003) 1809-1816
65. Ventura J., Lukoff D., Nuechterlein K.H., Liberman R.P., and Green M.F. Manual for the Expanded Brief Psychiatric Rating Scale. International Journal of Methods in Psychiatric Research 3 (1993) 227-244
66. Voglmaier M., Seidman L.J., Salisbury D., and McCarley R.W. Neuropsychological dysfunction in schizotypal personality disorder: A profile analysis. Biological Psychiatry 41 (1997) 530-540
67. Wechsler D. The Wechsler Adult Intelligence Scale-Revised manual (1981), Psychological Corporation, San Antonio, TX
68. Weinberger D.R., Berman K.F., Suddath R., and Torrey E.F. Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: A magnetic resonance imagining and regional cerebral blood flow study of discordant monozygotic twins. American Journal of Psychiatry 149 (1992) 890-897