Highly concentrated calcitriol and its analogues induce apoptosis of parathyroid cells and regression of the hyperplastic gland - Study in rats

Nephrology Dialysis Transplantation

Volumn 23, Issue 5, 2008, Pages 1529-1536

  Shiizaki, Kazuhiro ^a   Hatamura, Ikuji ^b   Negi, Shigeo ^b   Sakaguchi, Toshifumi ^b   Saji, Fumie ^b   Imazeki, Ikuo ^c   Kusano, Eiji ^a   Shigematsu, Takashi ^b   Akizawa, Tadao ^d  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^c CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^d SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell death; Electron microscopy; Hyperparathyroidism; Renal osteodystrophy; Vitamin D

Indexed keywords

22 OXACALCITRIOL; ALCOHOL; CALCITRIOL; CALCIUM; DOXERCALCIFEROL; PARICALCITOL; PHOSPHATE; PHOSPHATE BUFFERED SALINE; TOXIC SUBSTANCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM BLOOD LEVEL; CELL DEATH; CONTROLLED STUDY; DIET SUPPLEMENTATION; ELECTRON MICROSCOPY; ELECTROPHORESIS; INJECTION; MALE; MICROSCOPY; MORPHOLOGY; NEPHRECTOMY; NICK END LABELING; NONHUMAN; PARATHYROID CELL; PARATHYROID GLAND; PARATHYROID HORMONE BLOOD LEVEL; PARATHYROID HYPERPLASIA; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CALCITRIOL; CALCIUM; DISEASE MODELS, ANIMAL; HUMANS; HYPERPARATHYROIDISM, SECONDARY; HYPERPLASIA; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; PARATHYROID GLANDS; PARATHYROID HORMONE; PHOSPHORUS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 44449100111     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfm850     Document Type: Article

References (25)

1. Fukuda N, Tanaka H, Tominaga Y et al. Decreased 1,25-dihydroxyvitamin D3 receptor density is associated with amore severe form of parathyroid hyperplasia in chronic uremic patients. J Clin Invest 1993; 92: 1436-1443
2. Gogusev J, Duchambon P, Hory B et al. Decreased expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism. Kidney Int 1997; 51: 328-336
3. Block G, Klassen P, Lazarus J et al. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 2004; 15: 2208-2218
4. Akizawa T, Ohashi Y, Akiba T et al. Dose-response study of 22-oxacalcitriol in patients with secondary hyperparathyroidism. Ther Apher Dial 2004; 8: 480-491
5. Coyne DW, Grieff M, Ahya SN et al. Differential effects of acute administration of 19-Nor-1,25-dihydroxy-vitamin D2 and 1,25-dihydroxy-vitamin D3 on serumcalcium and phosphorus in hemodialysis patients. Am J Kidney Dis 2002; 40: 1283-1288
6. Frazao JM, Elangovan L, Maung HM et al. Intermittent doxercalciferol (1alpha-hydroxyvitamin D(2)) therapy for secondary hyperparathyroidism. Am J Kidney Dis 2000; 36: 550-561
7. Kitaoka M, Fukagawa M, Ogata E et al. Kurokawa K. Reduction of functioning parathyroid cell mass by ethanol injection in chronic dialysis patients. Kidney Int 1994; 46: 1110-1117
8. Kitaoka M. Ultrasonographic diagnosis of parathyroid glands and percutaneous ethanol injection therapy. Nephrol Dial Transplant 2003; 18 (Suppl 3): iii27-iii30
9. Shiizaki K, Negi S, Mizobuchi M et al. Effect of percutaneous calcitriol injection therapy on secondary hyperparathyroidism in uraemic patients. Nephrol Dial Transplant 2003; 18 (Suppl 3): iii42-iii46
10. Shiizaki K, Hatamura I, Negi S et al. Percutaneous maxacalcitol injection therapy regresses hyperplasia of parathyroid and induces apoptosis in uremia. Kidney Int 2003; 64: 992-1003
11. Shiizaki K, Negi S, Hatamura I et al. Direct injection of calcitriol or its analog into hyperplastic parathyroid glands induces apoptosis of parathyroid cell. Kidney Int 2006; 70 (Suppl 102): S12-S15
12. Shiizaki K, Negi S, Hatamura I et al. Biochemical and cellular effects of direct maxacalcitol injection into parathyroid gland in uremic rats. J Am Soc Nephrol 2005; 16: 97-108
13. Shiizaki K, Hatamura I, Negi S et al. Direct maxacalcitol injection into hyperplastic parathyroids improves skeletal changes in secondary hyperparathyroidism. Kidney Int 2006; 70: 486-495
14. Wyllie AH. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 1980; 284: 555-556
15. Shiizaki K, Hayakawa N, Imazeki I et al. Binding of highly concentrated maxacalcitol to the nuclear vitamin D receptors of parathyroid cells. Nephrol Dial Transplant 2007; 22: 1078-1086
16. Wagner D, Wagner N, Sukhatme P et al. Activation of vitamin D receptor by the Wilms' tumor gene product mediates apoptosis of renal cells. J Am Soc Nephrol 2001; 12: 1188-1196
17. Wang Q, Yang W, Uytingco M et al. 1,25-Dihydroxyvitamin D3 and all-trans-retinoic acid sensitise breast cancer cells to chemotherapy-induced cell death. Cancer Res 2000; 60: 2040-2048
18. Diaz G, Paraskeva C, Thomas M et al. Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy. Cancer Res 2000; 60: 2304-2312
19. Guzey M, Kitada S, Reed JC. Apoptosis induction by 1 alpha,25- dihydroxyvitamin D3 in prostate cancer. Mol Cancer Ther 2002; 1: 667-677
20. Fukagawa M, Okazaki R, Takano K et al. Regression of parathyroid hypertrophy by calcitriol-pulse therapy in patients on long-term dialysis. N Engl J Med 1990; 323: 421-422
21. Quarles D, Yohay A, Carroll A et al. Prospective trial of pulse oral versus intravenous calcitriol treatment of hyperparathyroidism in ESRD. Kidney Int 1994; 45: 1710-1721
22. Jara A, Gonzalez S, Felsenfeld J et al. Failure of high dose of calcitriol and hypercalcaemia to induce apoptosis in hyperplastic parathyroid glands of azotaemic rats. Nephrol Dial Transplant 2001; 16: 506-512
23. Canalejo A, Almaden Y, Torregrosa V et al. The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J Am Soc Nephrol 2000; 11: 1865-1872
24. Taniguchi M, Tokumoto M, Matsuda D et al. Parathyroid growth and regression in experimental uremia. Kidney Int 2006; 69: 464-470
25. Hoyer-Hansen M, Bastholm L, Mathiasen IS et al. Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ 2005; 12: 1297-1309