High replicated hepatitis B virus induces apoptosis of hepatocytes

National Medical Journal of China

Volumn 88, Issue 12, 2008, Pages 840-843

  Pan, Xiao Ben ^a   Han, Jin Chao ^a   Gao, Yan ^a   Wei, Lai ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

Author keywords

Apoptosis; Hepatitis B virus; Hepatocytes

Indexed keywords

CALCIUM PHOSPHATE; CASPASE 3; CASPASE 7; CYCLIN DEPENDENT KINASE 1; HEPATITIS B SURFACE ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 2; VIRUS DNA;

APOPTOSIS; ARTICLE; CELL GROWTH; CONTROLLED STUDY; CULTURE MEDIUM; ELECTRON MICROSCOPY; FLUORESCENCE ANALYSIS; GENE EXPRESSION PROFILING; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; LIVER CELL; MICROARRAY ANALYSIS; MITOSIS INHIBITION; NICK END LABELING; NONHUMAN; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUPERNATANT; VIRUS REPLICATION;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA, VIRAL; HEPATITIS B VIRUS; HEPATOCYTES; HUMANS; IN SITU NICK-END LABELING; MICROSCOPY, ELECTRON, TRANSMISSION; POLYMERASE CHAIN REACTION; TRANSFECTION; VIRUS REPLICATION;

EID: 44449092603     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Seeger C, Mason WS. Hepatitis B virus biology. Microbiol Mol Biol Rev, 2000,64:51-68.
2. Chinese source.
3. Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol, 2005,5: 215-229.
4. Chinese source.
5. Lenhoff RJ, Summers J. Construction of avian hepadnavirus variants with enhanced replication and cytopathicity in primary hepatocytes. J Virol, 1994,68:5706-5713.
6. Ma Z, Wen Y, Xiong S, et al. Experimental study on pathogenicity of precore mutants in Hepadnaviridae. Chin Med J, 1998,111:519-523.
7. Kao JH, Chen PJ, Lai MY, et al. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology, 2003,124:327-334.
8. Meuleman P, Libbrecht L, Wieland S, et al. Immune suppression uncovers endogenous cytopathic effects of the hepatitis H virus. J Virol, 2006,80:2797-2807.
9. Pan XB, Wei L, Chen HS, et al. Liver-derived cell lines QSG-7701 and HepG2 support different HBV replication patterns. Arch Virol, 2007,152:1159-1173.
10. Wang Y, Wei L, Jiang D, et al. In vitro resistance to interferon of hepatitis B virus with precore mutation. World J Gastroenterol, 2005,11:649-655.
11. Pan XB, Wei L, Han JC, et al. Cellular chromosome DNA interferes with fluorescence quantitative real-time PCR detection of HBV DNA in culture medium. J Med Virol, 2008,80:47-52.
12. Guo Y, Guo H, Zhang L, et al. Genomic analysis of anti-hepatitis B virus (HBV) activity by small interfering RNA and lamivudine in stable HBV-producing cells. J Virol, 2005,79:14392-14403.
13. Yang YH, Dudoit S, Luu P, et al. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res, 2002,30: e15.
14. Nakamoto Y, Kaneko S. Mechanisms of viral hepatitis induced liver injury. Curr Mol Med, 2003,3:537-544.
15. Hinds MG, Day CL. Regulation of apoptosis: uncovering the binding determinants. Curr Opin Struct Biol, 2005,15:690-699.
16. Cho SG, Choi EJ. Apoptotic signaling pathways: caspases and stress-activated protein kinases. J Biochem Mol Biol, 2002,35: 24-27.
17. Ito K, Kiyosawa N, Kumagai K, et al. Molecular mechanism investigation of cycloheximide-induced hepatocyte apoptosis in rat livers by morphological and microarray analysis. Toxicology, 2006,219:175-186.
18. Chaudhari BR, Murphy RF, Agrawal DK. Following the TRAIL to apoptosis. Immunol Res, 2006,35:249-262.
19. Foo NC, Ahn BY, Ma X, et al. Cellular vacuolization and apoptosis induced by hepatitis B virus large surface protein. Hepatology, 2002,36:1400-1407.
20. Chinese source.