The effect of aprotinin on risk of acute renal failure requiring dialysis after on-pump cardiac surgery

Anaesthesia and Intensive Care

Volumn 36, Issue 3, 2008, Pages 374-378

  Raajkumar, A ^a   Ho, K M ^a   Cokis, C ^a   Slade, N ^a  

^a ROYAL PERTH HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; APROTININ; CREATININE; HEMOSTATIC AGENT;

ACUTE KIDNEY FAILURE; ADULT; AORTA CLAMPING; ARTICLE; BLEEDING; BLOOD TRANSFUSION; CEREBROVASCULAR ACCIDENT; CORONARY ARTERY BYPASS GRAFT; CREATININE BLOOD LEVEL; DIALYSIS; DRUG EFFECT; ELECTIVE SURGERY; EMERGENCY SURGERY; HEART ATRIUM FIBRILLATION; HEART LEFT VENTRICLE FUNCTION; HEART SURGERY; HEART VALVE SURGERY; HUMAN; MAJOR CLINICAL STUDY; MORTALITY; RETROSPECTIVE STUDY; RISK ASSESSMENT; ANALYSIS OF VARIANCE; COHORT ANALYSIS; FEMALE; MALE; MIDDLE AGED; PEROPERATIVE COMPLICATION; POSTOPERATIVE COMPLICATION; RENAL REPLACEMENT THERAPY; RISK; TREATMENT OUTCOME;

ANALYSIS OF VARIANCE; APROTININ; COHORT STUDIES; CORONARY ARTERY BYPASS; FEMALE; HEMOSTATICS; HUMANS; INTRAOPERATIVE COMPLICATIONS; KIDNEY FAILURE, ACUTE; MALE; MIDDLE AGED; ODDS RATIO; POSTOPERATIVE COMPLICATIONS; RENAL DIALYSIS; RETROSPECTIVE STUDIES; RISK; TREATMENT OUTCOME;

EID: 44449084305     PISSN: 0310057X     EISSN: None     Source Type: Journal    
DOI: 10.1177/0310057x0803600308     Document Type: Article

References (18)

1. Henry DA, Carless PA, Moxey AJ, O'Connell D, Stokes BJ, McClelland B et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2007; 4:CD001886
2. American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Practice guidelines for perioperative blood transfusion and adjuvant therapies: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Transfusion and Adjuvant Therapies. Anesthesiology 2006; 105:198-208
3. Brown JR, Birkmeyer NJ, O'Connor GT. Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation 2007; 115:2801-2813
4. Mangano DT, Tudor IC, Dietzel C; for the Multicenter Study of Perioperative Ischemia Research Group, Ischemia Research and Education Foundation. The risk associated with aprotinin in cardiac surgery. N Engl J Med 2006; 354:353-365
5. Furnary AP, Wu Y, Hiratzka LF, Grunkemeier GL, Page US 3rd. Aprotinin does not increase the risk of renal failure in cardiac surgery patients. Circulation 2007; 116(11 Suppl):I127-133
6. Kertai MD, Varga KS, Royston D, London MJ, Szabolcs Z, Grebenik CR et al. Aprotinin and perioperative complications in cardiac surgery. J Cardiovasc Surg (Torino) 2007; 48:761-772
7. Van der Linden PJ, Hardy JF, Daper A, Trenchant A, De Hert SG. Cardiac surgery with cardiopulmonary bypass: does aprotinin affect outcome? Br J Anaesth 2007; 99:646-652
8. Daly DJ, Myles PS, Smith JA, Knight JL, Clavisi O, Bain DL et al; ANZCA Trials Group. Anticoagulation, bleeding and blood transfusion practices in Australasian cardiac surgical practice. Anaesth Intensive Care 2007; 35:760-768
9. Kajdacsy-Balla Amaral AC, Andrade FM, Moreno R, Artigas A, Cantraine F, Vincent JL. Use of the sequential organ failure assessment score as a severity score. Intensive Care Med 2005; 31:243-249
10. Davis R, Whittington R. Aprotinin. A review of its pharmacology and therapeutic efficacy in reducing blood loss associated with cardiac surgery. Drugs 1995; 49:954-983
11. Lemmer JH Jr, Stanford W, Bonney SL, Chomka EV, Karp RB, Laub GW et al. Aprotinin for coronary artery bypass grafting: effect on postoperative renal function. Ann Thorac Surg 1995; 59:132-136
12. Coleman CI, Rigali VT, Hammond J, Kluger J, Jeleniowski KW, White CM. Evaluating the safety implications of aprotinin use: the Retrospective Evaluation of Aprotinin in Cardio Thoracic Surgery (REACTS). J Thorac Cardiovasc Surg 2007; 133:1547-1552
13. Dietrich W, Busley R, Boulesteix AL. Effects of aprotinin dosage on renal function: an analysis of 8,548 cardiac surgical patients treated with different dosages of aprotinin. Anesthesiology 2008; 108:189-198
14. Okubadejo GO, Bridwell KH, Lenke LG, Buchowski JM, Fang DD, Baldus CR et al. Aprotinin may decrease blood loss in complex adult spinal deformity surgery, but it may also increase the risk of acute renal failure. Spine 2007; 32:2265-2271
15. Parvizi R, Azarfarin R, Hassanzadeh S. Ultra-low dose aprotinin effects on reducing the need for blood transfusion in cardiac surgery. Saudi Med J 2007; 28:49-53
16. Baric D, Biocina B, Unic D, Sutlic Z, Rudez I, Vrca VB et al. Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study. Eur J Cardiothorac Surg 2007; 31:366-371
17. Wijeysundera DN, Karkouti K, Dupuis JY, Rao V, Chan CT, Granton JT et al. Derivation and validation of a simplified predictive index for renal replacement therapy after cardiac surgery. JAMA 2007; 297:1801-1809
18. Arnold DM, Fergusson DA, Chan AK, Cook RJ, Fraser GA, Lim W et al. Avoiding transfusions in children undergoing cardiac surgery: a meta-analysis of randomized trials of aprotinin. Anesth Analg 2006; 102:731-737