Chamigrenelactone, a polyoxygenated sesquiterpene with a novel structural type and devoid of halogen from Laurencia obtusa

Tetrahedron Letters

Volumn 45, Issue 38, 2004, Pages 7065-7068

  Dorta, Enrique ^a   Díaz Marrero, Ana R ^a   Cueto, Mercedes ^a   D'Croz, Luis ^b,c   Maté, Juan L ^b,d   Darias, José ^a  

^a INSTITUTO DE PRODUCTOS NATURALES Y AGROBIOLOGÍA   (Spain)

^b SMITHSONIAN TROPICAL RESEARCH INSTITUTE   (Panama)

^c UNIVERSIDAD DE PANAMÁ   (Panama)

^d UNIVERSITY OF MIAMI   (United States)

Author keywords

Biogenesis; Chamigrene; Laurencia obtusa; Sesquiterpene

Indexed keywords

CHAMIGRENE LACTONE; HALOGEN; LACTONE; SESQUITERPENE; UNCLASSIFIED DRUG;

ALGA; ARTICLE; BIOGENESIS; CENTRAL AMERICA; CONTROLLED STUDY; LAURENCIA OBTUSA; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; NONHUMAN; OXYGEN CONCENTRATION; OXYGENATION; PROTEIN ISOLATION; SPECTRAL SENSITIVITY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

LAURENCIA; LAURENCIA OBTUSA;

EID: 4444383918     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.07.125     Document Type: Article

References (16)

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9. Laurencia obtusa was collected at Isla Grande, Panama. Dry sample (180 g) was extracted with dichloromethane at room temperature. The extract was concentrated to give a dark residue (956.1 mg), which was chromatographed by flash chromatography on silica gel. The fraction eluted with hexane-EtOAc (1:1) (112.2 mg) was further separated by gel filtration to give a fraction (9.3 mg), which was purified by HPLC (Jaigel-sil column 20 × 250 mm, flow 4.5 mL/min, hexane-EtOAc (1:1) to give compound 1 (1.0 mg). From the fraction eluted with hexane-EtOAc (9:1) (233.5 mg) obtusol (13.5 mg) and dechloroelatol (10.8 g) were obtained after gel filtration chromatography (79.3 mg) and further HPLC (Jaigel-sil column 20 × 250 mm, flow 4.5 mL/min, hexane-AcOEt (9:1)
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