Synthesis of cyclopropane isosteres of the antiepilepsy drug vigabatrin and evaluation of their inhibition of GABA aminotransferase

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 19, Issue 4, 2004, Pages 293-301

  Wang, Zhiyong ^a   Silverman, Richard B ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

GABA; GABA AT; Vigabatrin; Aminobutyric acid; Aminobutyric acid aminotransferase

Indexed keywords

3 AMINO 3 (1' CYANOCYCLOPROPYL)PROPANOIC ACID; 3 AMINO 3 CYCLOPROPYLPROPANOIC ACID; 4 AMINO 4 (1' CYANOCYCLOPROPYL)BUTYRIC ACID; 4 AMINO 4 CYCLOPROPYLBUTYRIC ACID; 4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRATE AMINOTRANSFERASE INHIBITOR; ANTICONVULSIVE AGENT; CYANIDE; CYCLOPROPANE DERIVATIVE; ENAMINE; FUNCTIONAL GROUP; PYRIDOXAL 5 PHOSPHATE; UNCLASSIFIED DRUG; VIGABATRIN; VINYL DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INACTIVATION; ENZYME SUBSTRATE; MICHAEL ADDITION; PRIORITY JOURNAL;

EID: 4444360016     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/14756360409162441     Document Type: Article

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