Palladium catalysed synthesis of cyclic amidines and imidates

Tetrahedron Letters

Volumn 45, Issue 38, 2004, Pages 6995-6996

  Saluste, C Gustaf ^a   Crumpler, Simon ^a   Furber, Mark ^b   Whitby, Richard J ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Amidine; Imidate; Isonitrile; Palladium catalysed

Indexed keywords

ALCOHOL; AMINE; BROMINE DERIVATIVE; ISONITRILE DERIVATIVE; PALLADIUM;

ARTICLE; CATALYSIS; CHEMICAL MODIFICATION;

INSERTION SEQUENCES;

EID: 4444356745     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.07.151     Document Type: Article

References (11)

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10. The (E)-isomer of 5/6 was more stable than the (Z)- by between 24 (5b) and 72 (6d) kJ/mol according DFT (B3YLP/6-31G*) calculations. Calculations were carried out using Spartan04, Wavefuntion Inc. In the case of N-tert-butyl-substituted imidates E/Z isomerisation would be expected to be fast at room temperature: D.E. Gallis, and D.R. Crist Magn. Reson. Chem. 1987, 25, 480-483.
11. 1.