Cluster headache: Focus on emerging therapies

Expert Review of Neurotherapeutics

Volumn 4, Issue 5, 2004, Pages 895-907

  Matharu, Manjit S ^a   Goadsby, Peter J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cluster headache; Hypothalamic stimulation; Lithium; Methysergide; Occipital nerve; Octreotide; Oxygen; Topiramate; Triptans; Verapamil

Indexed keywords

BACLOFEN; CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; CIS CAPSAICIN; CORTICOSTEROID; DEXAMETHASONE; DIHYDROERGOTAMINE; ELETRIPTAN; ERGOTAMINE; ERGOTAMINE DERIVATIVE; GABAPENTIN; LEUPRORELIN; LIDOCAINE; LITHIUM; MELATONIN; METHYSERGIDE; NARATRIPTAN; NONSTEROID ANTIINFLAMMATORY AGENT; OLANZAPINE; OPIATE AGONIST; PIZOTIFEN; PREDNISOLONE; SOMATOSTATIN; SOMATOSTATIN DERIVATIVE; SUMATRIPTAN; TOPIRAMATE; UNINDEXED DRUG; VALPROIC ACID; VERAPAMIL; ZOLMITRIPTAN;

ANKLE EDEMA; ANOREXIA; ATAXIA; BONE NECROSIS; BRADYCARDIA; BURNING SENSATION; CHEMOPROPHYLAXIS; CLINICAL EXAMINATION; CLINICAL TRIAL; CLUSTER HEADACHE; CONFUSION; CONSTIPATION; DIARRHEA; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; DIZZINESS; DRUG CHOICE; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; EXTRAPYRAMIDAL SYMPTOM; FATIGUE; HEART BLOCK; HUMAN; HYPERBARIC OXYGEN; HYPERTENSION; HYPOTHYROIDISM; LEUKOCYTOSIS; LIBIDO DISORDER; NAUSEA; NOSE IRRITATION; NYSTAGMUS; PATHOPHYSIOLOGY; PATIENT EDUCATION; POLYURIA; REVIEW; SEIZURE; SIDE EFFECT; SOMNOLENCE; SYSTEMATIC REVIEW; VOMITING;

ANALGESICS; CLUSTER HEADACHE; DEEP BRAIN STIMULATION; DIAGNOSIS, DIFFERENTIAL; DRUG THERAPY; EXPERT TESTIMONY; FEMALE; HUMANS; MALE; NEUROSURGERY; NEUROTRANSMITTER AGENTS; OXYGEN; RECURRENCE;

EID: 4444351009     PISSN: 14737175     EISSN: None     Source Type: Journal    
DOI: 10.1586/14737175.4.5.895     Document Type: Review

References (108)

1. D'Alessandro R, Gamberini G, Benassi G, Morganti G, Cortelli P, Lugaresi E. Cluster headache in the Republic of San Marino. Cephalalgia 6, 159-162 (1986).
2. Ekbom K, Ahlborg B, Schele R. Prevalence of migraine and cluster headache in Swedish men of 18. Headache 18, 9-19 (1978).
3. Swanson JW, Yanagihara T, Stang PE et al. Incidence of cluster headaches: a population-based study in Olmsted County, Minnesota. Neurology 44, 433-437 (1994).
4. Sjaastad O, Bakketeig LS. Cluster headache prevalence. Vaga study of headache epidemiology. Cephalalgia 23, 528-533 (2003).
5. Torelli P, Beghi E, Manzoni GC. Cluster headache prevalence in the Italian general population. Cephalagia 23, 598 (2003).
6. Manzoni GC. Gender ratio of cluster headache over the years: a possible role of changes in lifestyle. Cephalalgia 18, 138-142 (1998).
7. Bahra A, May A, Goadsby PJ. Cluster headache: a prospective clinical study with diagnostic implications. Neurology 58, 354-361 (2002).
8. Lance JW, Goadsby PJ. Mechanisms and management of headache. Butterworth-Heinemann, London, UK (1998).
9. Headache Classification Committee of The International Headache Society. The International Classification of Headache Disorders. Second Edition. Cephalalgia 24, 1-195 (2004).
10. Silberstein SD, Niknam R, Rozen TD, Young WB. Cluster headache with aura. Neurology 54, 219-221 (2000).
11. Siow HC, Young WB, Peres MF, Rozen TD, Silberstein SD. Hemiplegic cluster. Headache 42, 136-139 (2002).
12. Goadsby PJ, Lipton RB. A review of paroxysmal hemicranias, SUNCT syndrome and other short-lasting headaches with autonomic feature, including new cases. Brain 120, 193-209 (1997).
13. May A, Bahra A, Buchel C, Frackowiak RS, Goadsby PJ. Hypothalamic activation in cluster headache attacks. Lancet 552, 275-278 (1998). Positron emission tomography study showing activation of the posterior inferior hypothalamus in cluster headache (CH).
14. Sprenger T, Boecker H, Tolle TR, Bussone G, May A, Leone M. Specific hypothalamic activation during a spontaneous cluster headache attack. Neurology 62, 516-517 (2004).
15. May A, Ashburner J, Buchel C et al. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nature Med. 5, 836-838 (1999).
16. Manzoni GC, Micieli G, Granella F, Tassorelli C, Zanferrari C, Cavallini A. Cluster headache-course over ten years in 189 patients. Cephalalgia 11, 169-174 (1991).
17. Igarashi H, Sakai F. Natural history of cluster headache. Cephalalgia 16, 390-391 (1996).
18. The Sumatriptan Cluster Headache Study Group. Treatment of acute cluster headache with sumatriptan. N. Engl. J. Med. 325, 322-326 (1991).
19. Ekbom K, Waldenlind E, Cole J, Pilgrim A, Kirkham A. Sumatriptan in chronic cluster headache: results of continuous treatment for eleven months. Cephalalgia 12, 254-256 (1992).
20. Ekbom K, Krabbe A, Micieli G et al. Cluster headache attacks treated for up to three months with subcutaneous Sumatriptan (6 mg). Sumatriptan Cluster Headache Long-term Study Group. Cephalalgia 15, 230-236 (1995).
21. Gobel H, Lindner V, Heinze A, Ribbat M, Deuschl G. Acute therapy for cluster headache with sumatriptan: findings of a 1-year long-term study. Neurology 51, 908-911 (1998).
22. Manzoni GC. Cluster headache and lifestyle: remarks on a population of 374 male patients. Cephalalgia 19, 88-94 (1999).
23. Van Vliet JA, Bahra A, Martin V et al. Intranasal sumatriptan in cluster headache: Randomized placebo-controlled double-blind study. Neurology 60, 630-633 (2003).
24. Monstad I, Krabbe A, Micieli G et al. Preemptive oral treatment with sumatriptan during a cluster period. Headache 35, 607-613 (1995).
25. Bahra A, Gawel MJ, Hardebo JE, Millson D, Breen SA, Goadsby PJ. Oral zolmitriptan is effective in the acute treatment of cluster headache. Neurology 54, 1832-1839 (2000).
26. Fogan L. Treatment of cluster headache. A double-blind comparison of oxygen vs. air inhalation. Arch. Neurol. 42, 362-363 (1985).
27. Kudrow L. Response of cluster headache attacks to oxygen inhalation. Headache 21, 1-4 (1981).
28. Igarashi H, Sakai F, Tazaki Y. The mechanism by which oxygen interrupts cluster headache. Cephalalgia 11, 238-239 (1991).
29. Porta M, Granella F, Coppola A, Longoni C, Manzoni GC. Treatment of cluster headache attacks with hyperbaric oxygen. Cephalagia 11(Suppl. 11), 236-237 (1991).
30. Di Sabato F, Fusco BM, Pelaia P, Giacovazzo M. Hyperbaric oxygen therapy in cluster headache. Pain 52, 243-245 (1993).
31. Nilsson Remahl AI, Ansjon R, Lind F, Waldenlind E. Hyperbaric oxygen treatment of active cluster headache: a double-blind placebo-controlled cross-over study. Cephalalgia 22, 730-739 (2002).
32. Robbins L. Intranasal lidocaine for cluster headache. Headache 35, 83-84 (1995).
33. Matharu MS, Boes CJ, Goadsby PJ. Management of trigeminal autonomic cephalgias and hemicrania continua. Drugs 63, 1637-1677 (2003). 8 Reviews the primary headache syndromes recognized as trigeminal antonomic cephalgias. It contains a detailed literature survey on the reports of medical treatments for CH.
34. Friedman AP, Mikropoulos HE. Cluster headaches. Neurology 8, 653-663 (1958).
35. Horton BT. Histaminic cephalgia. Lancet 72, 92-98 (1952).
36. Dodick DW, Rozen TD, Goadsby PJ, Silberstein SD. Cluster headache. Cephalalgia 20, 787-803 (2000). Comprehensive review of the clinical phenotype, pathophysiology and treatments of CH.
37. Andersson PG, Jespersen LT. Dihydroergotamine nasal spray in the treatment of attacks of cluster headache. A double-blind trial versus placebo. Cephalalgia 6, 51-54 (1986).
38. Goadsby PJ. The pharmacology of headache. Prog. Neurobiol. 62, 509-525 (2000).
39. Goadsby PJ, Edvinsson L. Human in vivo evidence for trigerninovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies. Brain 117, 427-434 (1994).
40. Fanciullacci M, Alessandri M, Figini M, Geppetti P, Michelacci S. Increase in plasma calcitonin gene-related peptide from the extracerebral circulation during nitroglycerin-induced cluster headache attack Pain 60, 119-123 (1995).
41. Helyes Z, Pinter E, Nemeth J et al. Anti-inflammatory effect of synthetic somatostatin analogs in the rat. Br. J. Pharmacol. 134, 1571-1579 (2001).
42. Fassler JE, O'Dorisio TM, Mekhjian HS, Gaginella TS. Octreotide inhibits increases in short-circuit current induced in rat colon by VIP, substance P, serotonin and aminophylline. Regul. Pept. 29, 189-197 (1990).
43. Sicuteri F, Geppetti P, Marabini S, Lembeck F. Pain relief by somatostatin in attacks of cluster headache. Pain 18, 359-365 (1984).
44. Geppetti P, Brocchi A, Caleri D, Marabini S, Raino L, Renzi D. Somatostatin for cluster headache attack. In: Updating in Headache. Pfaffenrath V, Lundberg PO, Sjaastad O (Eds). Springer-Verlag, NY, USA, 302-305 (1985).
45. Matharu MS, Levy MJ, Meeran K, Goadsby PJ. Subcutaneous octreotide is effective in the treatment of acute cluster headache: a double-blind placebo-controlled crossover study. Cephalagia 23, 580 (2003).
46. Rozen TD. Olanzapine as an abortive agent for cluster headache. Headache 41, 813-816 (2001).
47. Gabai IJ, Spierings EL. Prophylactic treatment of cluster headache with verapamil. Headache 29, 167-168 (1989).
48. Bussone G, Leone M, Peccarisi C et al. Double-blind comparison of lithium and verapamil in cluster headache prophylaxis. Headache 30, 411-417 (1990).
49. Leone M, D'Amico D, Frediani F et al. Verapamil in the prophylaxis of episodic cluster headache: a double-blind study versus placebo. Neurology 54, 1382-1385 (2000).
50. Krabbe A, Steiner TJ. Prophylactic treatment of cluster headache. In: Cluster Headache Syndrome in General Practice: Basic Concepts. Sjaastad O, Nappi G (Eds). Smith-Gordon, London, UK, 91-96 (2000).
51. Kudrow L. Lithium prophylaxis for chronic cluster headache. Headache 17, 15-18 (1977).
52. Ekbom K. Lithium for cluster headache: review of the literature and preliminary results of long-term treatment. Headache 21, 132-139 (1981).
53. Kudrow L. Cluster headache. In: Clinical, Therapeutic, Conceptual and Research Aspects. Blau JN (Ed.). Chapman and Hall, London, UK (1987).
54. Curran DA, Hinterberger H, Lance JW. Methysergide. Res. Clin. Studies Headache 1, 74-122 (1967).
55. Graham JR, Suby HI, LeCompte PR, Sadowsky NL. Fibrotic disorders associated with methysergide therapy for headache. N. Engl. J. Med. 274, 360-368 (1966).
56. Raskin NH. Headache. Churchill livingstone, NY, USA (1988).
57. Berde B, Schild HO. Ergot Alkaloids and Related Compounds. Springer-Verlag, Berlin, Germany (1978).
58. Garrison JC. Histamine, bradykinin, 5-hydroxytryptamine and their antagonists. In: The Pharmacological Basis of Therapeutics. Gilman AG, Rail TW, Niles AS, Taylor P (Eds). Pergamon Press, NY, USA, 595 (1990).
59. Saxena PR, Den Boer MO. Pharmacology of antimigraine drugs. J. Neurol. 238, S28-S35 (1991).
60. Blakeborough P, Fowler PA, Ashford EA. The use of sumatriptan in patients taking migraine prophylactic agents. Cephalalgia 13, 163 (1993).
61. Liston H, Bennett L, Usher B Jr, Nappi J. The association of the combination of sumatriptan and methysergide in myocardial infarction in a premenopausal woman. Arch. Intern. Med. 159, 511-513 (1999).
62. Symonds CP. A particular variety of headache. Brain 79, 217-232 (1956).
63. Marner PJ, Silberstein SD, Schulman EA, Hopkins MM. The treatment of cluster headache with repetitive intravenous dihydroergotamine. Headache 31, 525-532 (1991).
64. Speight TM, Avery GS. Pizotifen (BC-105); a review of its pharmacological properties and its therapeutic efficacy in vascular headaches. Drugs 3, 159-203 (1972).
65. Ekbom K. Prophylactic treatment of cluster headache with a new serotonin antagonist, BC 105. Acta Neurol. Scand. 45, 601-610 (1969).
66. Couch JR Jr, Ziegler DK. Prednisone therapy for cluster headache. Headache 18, 219-221 (1978).
67. Anthony M, Daher BN. Mechanism of action of steroids in cluster headache. In: New Advances in Headache Research. Volume Two. Rose FC (Ed.). Smith Gordon, London, UK, 271-274 (1992).
68. Mirzai R, Chang C, Greenspan A, Gershwin ME. The pathogenesis of osteonecrosis and the relationships to corticosteroids. J. Asthma 36, 77-95 (1999).
69. Hering R, Kuritzky A. Sodium valproate in the treatment of cluster headache: an open clinical trial. Cephalalgia 9, 195-198 (1989).
70. Freitag FG, Diamond S, Diamond ML, Urban G, Pepper B. Divalproex sodium in the preventative treatment of cluster headache. Headache 40, 408 (2000).
71. Gallagher RM, Mueller LL, Freitag FG. Divalproex sodium in the treatment of migraine and cluster headaches. J. Am. Osteopath. Assoc. 102, 92-94 (2002).
72. El Amrani M, Massiou H, Bousser M. A negative trial of sodium valproate in cluster headache: methodological issues. Cephalalgia 22, 205-208 (2002).
73. Wheeler SD, Carrazana EJ. Topiramate-treated cluster headache. Neurology 53, 234-236 (1999).
74. Forderreuther S, Mayer M, Straube A. Treatment of cluster headache with topiramate: effects and side effects in five patients. Cephalagia 22, 186-189 (2002).
75. Lainez MJ, Pascual J, Pascual AM, Santonja JM, Ponz A, Salvador A. Topiramate in the prophylactic treatment of cluster headache. Headache 43, 784-789 (2003).
76. Mathew NT, Kailasam J, Meadors L. Prophylaxis of migraine, transformed migraine and cluster headache with topiramate. Headache 42, 796-803 (2002).
77. Leone M, Dodick D, Rigamonti A et al. Topiramate in cluster headache prophylaxis: an open trial. Cephalalgia 23, 1001-1002 (2003).
78. Ahmed F. Chronic cluster headache responding to gabapentin: a case report. Cephalalgia 20, 252-253 (2000).
79. Tay BA, Ngan Kee WD, Chung DC. Gabapentin for the treatment and prophylaxis of cluster headache. Reg. Anesth. Pain Med. 26, 373-375 (2001).
80. Leandri M, Luzzani M, Cruccu G, Gottlieb A Drug-resistant cluster headache responding to gabapentin: a pilot study. Cephalalgia 21, 744-746 (2001).
81. Brzezinski A. Melatonin in humans. N. Engl. J. Med. 336, 186-195 (1997).
82. Waldenlind E, Gustafsson SA, Ekbom K, Wetterberg L. Circadian secretion of cortisol and melatonin in cluster headache during active cluster periods and remission. J. Neurol. Neurosurg. Psych. 50, 207-213 (1987).
83. Leone M, Lucini V, D'Amico D et al. Twenty-four hour melatonin and cortisol plasma levels in relation to timing of cluster headache. Cephalalgia 15, 224-229 (1995).
84. Leone M, D'Amico D, Moschiano F, Fraschini F, Bussone G. Melatonin versus placebo in the prophylaxis of cluster headache: a double-blind pilot study with parallel groups. Cephalalgia 16, 494-496 (1996).
85. Peres MF, Rozen TD. Melatonin in the preventive treatment of chronic cluster headache. Cephalalgia 21, 993-995 (2001).
86. Nicolodi M, Sicuteri F, Poggioni M. Hypothalamic modulation of nociception and reproduction in cluster headache. I. Therapeutic trials of leuprolide. Cephalalgia 13, 253-257 (1993).
87. Sicuteri F, Fanciullacci M, Nicolodi M et al. Substance P theory: a unique focus on the painful and painless phenomena of cluster headache. Headache 30, 69-79 (1990).
88. Fusco BM, Marabini S, Maggi CA, Fiore G, Geppetti P. Preventive effect of repeated nasal applications of capsaicin in cluster headache. Pain 59, 321-325 (1994).
89. Fusco BM, Fiore G, Gallo F, Martelletti P, Giacovazzo M. 'Capsaicin-sensitive' sensory neurons in cluster headache: pathophysiological aspects and therapeutic indication. Headache 34, 132-137 (1994).
90. Marks DR, Rapoport A, Padla D et al. A double-blind placebo-controlled trial of intranasal capsaicin for cluster headache. Cephalalgia 13, 114-116 (1993).
91. Saper JR, Klapper J, Mathew NT, Rapoport A, Phillips SB, Bernstein JE. Intranasal civamide for the treatment of episodic cluster headaches. Arch. Neurol. 59, 990-994 (2002).
92. Peres MF, Stiles MA, Slow HC, Rozen TD, Young WB, Silberstein SD. Greater occipital nerve blockade for cluster headache. Cephalalgia 22, 520-522 (2002).
93. Mulder LJ, Spierings EL. Naratriptan in the preventive treatment of cluster headache. Cephalalgia 22, 815-817 (2002).
94. Wober C, Vigl K, Wessely P. Eletriptan for short-term prophylaxis of cluster headache. Cephalagia 22, 584 (2002).
95. Hering-Hanit R, Gadoth N. The use of baclofen in cluster headache. Curr. Pain Headache Rep. 5, 79-82 (2001).
96. Evers S, Rahmann A, Vollmer-Haase J, Husstedt IW. Treatment of headache with botulinum toxin A - a review according to evidence-based medicine criteria. Cephalalgia 22, 699-710 (2002).
97. Caviness VS Jr, O'Brien P. Cluster headache: response to chlorpromazine. Headache 20, 128-131 (1980).
98. Diamond S, Freitag FG, Prager J. Treatment of intractable cluster headache. Headache 26, 42-46 (1986).
99. D'Andrea G, Perini F, Granella F, Cananzi A, Sergi A. Efficacy of transdermal clonidine in short-term treatment of cluster headache: a pilot study. Cephalalgia 15, 430-433 (1995).
100. Kirkpatrick PJ, O'Brien MD, MacCabe JJ. Trigeminal nerve section for chronic migrainous neuralgia. Br. J. Neurosurg. 7, 483-490 (1993).
101. Mathew NT, Hurt W. Percutaneous radiofiequency trigeminal gangliorhizolysis in intractable cluster headache. Headache 28, 328-331 (1988).
102. Lovely TJ, Kotsiakis X, Jannetta PJ. The surgical management of chronic cluster headache. Headache 38, 590-594 (1998).
103. Franzini A, Ferroli P, Leone M, Broggi G. Stimulation of the posterior hypothalamus for treatment of chronic intractable cluster headaches: first reported series. Neurosurgery 52, 1099-1101 (2003).
104. Leone M, Franzini A, D'Amico D et al. A three year experience with hypothalamic deep brain stimulation to relieve intractable chronic cluster headache. Cephalagia. 23, 579 (2003).
105. Dodick D, Trentman T, Zimmerman R, Eric E. Occipital nerve stimulation for intractable chronic primary headache disorders. Cephalagia 23, 701 (2003).
106. Weiner R. Peripheral neurostimulation for control of intractable occipital neuralgia. Neuromodulation 2, 217-221 (1999).
107. Matharu MS, Bartsch T, Ward N, Frackowiak RS, Weiner R, Goadsby PJ. Central neuromodulation in chronic migraine patients with suboccipital stimulators: a PET study. Brain 127, 220-230 (2004).
108. Tfelt-Hansen P. Prophylactic pharmacotherapy of cluster headache. In: Cluster Headache & Related Conditions. Olesen J, Goadsby PJ (Eds). Oxford University Press, Oxford, UK, 257-263 (1999).