A semi-automated 96-well solid phase extraction and high performance liquid chromatographic determination of a selective GABA-A receptor agonist in human and rat plasma using fluorescence detection

Journal of Liquid Chromatography and Related Technologies

Volumn 27, Issue 15, 2004, Pages 2329-2341

  Hsieh, J Y K ^a   Lin, L ^a   Matuszewski, B K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

96 Well solid phase extraction; Fluorescence detection; HPLC; Human and rat plasma; Selective GABA A receptor agonist

Indexed keywords

DRUG DOSAGE; ENGINEERING RESEARCH; FLUORESCENCE; QUALITY CONTROL; THROUGHPUT;

HUMAN PLASMA; RAT PLASMA; SOLID PHASE EXTRACTION (SPE); WAVELENGTH;

LIQUID CHROMATOGRAPHY;

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 7 CYCLOBUTYL 6 (2 METHYL 2H 1,2,4 TRIAZOL 3 YLMETHOXY) 3 PHENYL 1,2,4 TRIAZOLO[4,3 B]PYRIDAZINE; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; AUTOMATION; CONTROLLED STUDY; DILUTION; DRUG BLOOD LEVEL; ELUTION; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; NONHUMAN; PLASMA; RAT; SOLID PHASE EXTRACTION; VALIDATION PROCESS;

ANIMALIA;

EID: 4444350299     PISSN: 10826076     EISSN: None     Source Type: Journal    
DOI: 10.1081/JLC-200028133     Document Type: Article

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