Cell mediated immune response elicited in mice after immunization with the P64k meningococcal protein: Epitope mapping

FEMS Immunology and Medical Microbiology

Volumn 42, Issue 2, 2004, Pages 233-239

  González, Sonia ^a   Nazábal, Consuelo ^a   Rao, Kanury V S ^b   Reyes, Osvaldo ^a   Garay, Hilda E ^a   Caballero, Evelin ^a   Alvarez Obregón, Julio C ^a   Sardiñas, Gretel ^a   Silva, Ricardo ^a  

^a CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY ICGEB   (India)

Author keywords

Helper T cell epitope; Meningococci; P64k; T cell response

Indexed keywords

AMINO ACID DERIVATIVE; BACTERIAL PROTEIN; INTERLEUKIN 12; INTERLEUKIN 4; MENINGOCOCCUS VACCINE; PROTEIN P64K; RECOMBINANT ANTIGEN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CONCENTRATION (PARAMETERS); DOSE RESPONSE; EPITOPE MAPPING; HELPER CELL; IMMUNIZATION; INGUINAL LYMPH NODE; LYMPH NODE CELL; LYMPHOCYTE PROLIFERATION; MOLECULE; MOUSE; NEISSERIA MENINGITIDIS; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL OUTER MEMBRANE PROTEINS; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; FEMALE; IMMUNIZATION; LYMPH NODES; LYMPHOCYTE ACTIVATION; MENINGOCOCCAL INFECTIONS; MENINGOCOCCAL VACCINES; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; NEISSERIA MENINGITIDIS; PEPTIDES; RECOMBINANT PROTEINS; TH1 CELLS;

EID: 4444345352     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.femsim.2004.05.007     Document Type: Article

References (38)

1. Peltola H. Meningococcal vaccines. Current status and future possibilities. Drugs. 55:1998;347-366
2. Guillén G., Alvarez A., Silva R., Morera V., Gonzalez S., Musacchio A., Besada V., Coizeau E., Caballero E., Nazabal C., Carmenate T., Gonzalez L.J., Estrada R., Tambara Y., Padron G., Herrera L. Expression in Escherichia coli of the lpdA gene, protein sequence analysis and immunological characterization of the P64k protein from Neisseria meningitidis. Biotechnol. Appl. Biochem. 27:1998;189-196
3. Gómez R., Madrazo J., González J., Chinea G., Musacchio A., Rodríguez A., Padrón G. Functional and structural characterization of the recombinant P64k protein of Neisseria meningitidis. Biotecnología Aplicada. 16:1999;83-87
4. Li I., Pernot L., Prange T., Saludjian P., Schiltz M., Fourme R., Padron G. Molecular structure of the lipoamide dehydrogenase domain of a surface antigen from Neisseria meningitidis. J. Mol. Biol. 269:1997;129-141
5. González S., Viña L., Nazábal C., Chinea G., Caballero E., Musacchio A. B-cell epitope mapping of the Neisseria meningitidis P64k protein using overlapping peptides. Biotechnol. Appl. Biochem. 32:2000;1-8
6. González S., Alvarez A., Caballero E., Viña L., Guillen G., Silva R. P64k meningococcal protein as immunological carrier for weak immunogens. Scand. J. Immunol. 52:2000;113-116
7. González G., Crombet T., Catalá M., Mirabal V., Hernández J.C., González Y., Marinello P., Guillén G., Lage A. A novel cancer vaccine composed of human recombinant epidermal growth factor linked to a carrier protein: Report of a pilot clinical trial. Ann. Oncol. 9:1998;1-5
8. Nazábal C., Carmenate T., Cruz S., Gonzalez S., Silva R., Musacchio A., Delgado M., Chinea G. Mapping of monoclonal antibodies specific to P64k: a common antigen of several isolates of Neisseria meningitidis. Can. J. Microbiol. 47:2001;158-164
9. United States Pharmacopeia-USP XXIV (2000), United States Pharmacopeia Convention, 24-19 ed
10. Expósito N., Mestre M., Silva R., Nazábal C., Peña M., Martínez N., Font M., Guillén G. Preformulation study of the vaccine candidate P64k against Neisseria meningitidis. Biotechnol. Appl. Biochem. 29:1999;113-119
11. Mills K.H.G. Induction and detection of T-cell responses. Robinson A., Farrar G.H., Wiblin C.N. Vaccine Protocols. 1996;197-222 Humana Press, Totowa, NJ
12. Mills K.H.G. Recognition of foreign antigen by T cells and their role in immune protection. Curr. Opinion Infect. Dis. 2:1989;804-814
13. Mills K.H.G. Processing of viral antigens and presentation to class II-restricted T cells. Immunol. Today. 7:1986;260-263
14. Mosmann T.R., Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:1989;145-173
15. Gupta R.K., Relyveld E.H., Lindblad E.B., Bizzini B., Ben Efraim S., Gupta C.K. Adjuvants - a balance between toxicity and adjuvanticity. Vaccine. 11:1993;293-306
16. Schijns V.E. Immunological concepts of vaccine adjuvant activity. Curr. Opin. Immunol. 12:2000;456-463
17. Gupta R.K., Siber G.R. Adjuvants for human vaccines - current status, problems and future prospects. Vaccine. 13:1995;1263-1276
18. Gonzalez S., Nazabal C., Viña L., Caballero E. Influence of several adjuvants on the immune response against a recombinant meningococcal high molecular weight antigen. Dev. Biol. Stand. 92:1998;269-276
19. Berzofsky J.A., Brett S.J., Streicher H.Z., Takahashi H. Antigen processing for presentation to T lymphocytes: function, mechanisms, and implications for the T-cell repertoire. Immunol. Rev. 106:1988;5-31
20. Thorpe R., Wadhwa M., Bird C.R., Mire-Sluis A.R. Detection and measurement of cytokines. Blood Rev. 6:1992;133-148
21. Swain S.L., McKenzie D.T., Weinberg A.D., Hancock W. Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells. J. Immunol. 141:1988;3445-3455
22. Coffman R.L., Seymour B.W., Lebman D.A., Hiraki D.D., Christiansen J.A., Shrader B., Cherwinski H.M., Savelkoul H.F., Finkelman F.D., Bond M.W. The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol. Rev. 102:1988;5-28
23. Lamb J.R., Ivanyi J., Rees A.D., Rothbard J.B., Howland K., Young R.A., Young D.B. Mapping of T cell epitopes using recombinant antigens and synthetic peptides. EMBO J. 6:1987;1245-1249
24. Maeji N.J., Bray A.M., Geysen H.M. Multi-pin peptide synthesis strategy for T cell determinant analysis. J. Immunol. Meth. 134:1990;23-33
25. Deng H., Fosdick L., Sercarz E. The involvement of antigen processing in determinant selection by class II MHC and its relationship to immunodominance. APMIS. 101:1993;655-662
26. Taborda C.P., Juliano M.A., Puccia R., Franco M., Travassos L.R. Mapping of the T-cell epitope in the major 43-kilodalton glycoprotein of Paracoccidioides brasiliensis which induces a Th-1 response protective against fungal infection in BALB/c mice. Infect. Immun. 66:1998;786-793
27. Vandebriel R.J., van der K.M., Geerse L., Steerenberg P.A., Krul M.R. A helper T-cell epitope of the E7 protein of human papillomavirus type 16 in BALB/c mice. Virus Res. 37:1995;13-22
28. Delvig A.A., Rosenqvist E., Oftung F., Robinson J.H. T-Cell epitope mapping the PorB protein of serogroup B Neisseria meningitidis in B10 congenic strains of mice. Clin. Immunol. Immunopathol. 85:1997;134-142
29. Duarte, C., Guillén, G., Alvarez, A., Carpio, E., Quintana, D., Gómez, C.E., Silva, R., Nazabal, C., Leal, M.J., Martin, A. System for the expression of heterologous antigens as fusion proteins. European Patent EP 0 816 506
30. Singh H., Raghava G.P. ProPred: prediction of HLA-DR binding sites. Bioinformatics. 17:2001;1236-1237
31. Swain, M.T., Brooks, A.J., Kemp, G.J.L. (2001) An automated approach to modelling class II MHC alleles and predicting peptide binding. In: Proceedings of the Second IEEE International Symposium on Bio-Informatics and Biomedical Engineering, pp. 81-88. IEEE Computer Society Press
32. Parker K.C., Bednarek M.A., Coligan J.E. Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains. J. Immunol. 152:1994;163-175
33. Reche P.A., Glutting J.P., Reinherz E.L. Prediction of MHC class I binding peptides using profile motifs. Hum. Immunol. 63:2002;701-709
34. Panina-Bordignon P., Tan A., Termijtelen A., Demotz S., Corradin G., Lanzavecchia A. Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur. J. Immunol. 19:1989;2237-2242
35. Babbitt B.P., Allen P.M., Matsueda G., Haber E., Unanue E.R. Binding of immunogenic peptides to Ia histocompatibility molecules. Nature. 317:1985;359-361
36. Buus S., Colon S., Smith C., Freed J.H., Miles C., Grey H.M. Interaction between a processed ovalbumin peptide and Ia molecules. Proc. Natl. Acad. Sci. USA. 83:1986;3968-3971
37. Guillet J.G., Lai M.Z., Briner T.J., Smith J.A., Gefter M.L. Interaction of peptide antigens and class II major histocompatibility complex antigens. Nature. 324:1986;260-262
38. Perez A., Dickinson F., Cinza Z., Ruiz A., Serrano T., Sosa J., Gonzalez S., Gutierrez Y., Nazabal C., Gutierrez O., Guzman D., Diaz M., Delgado M., Caballero E., Sardiñas G., Alvarez A., Martin A., Guillen G., Silva R. Safety and preliminary immunogenicity of the recombinant outer membrane protein P64k of Neisseria meningitidis in human volunteers. Biotechnol. Appl. Biochem. 34:2001;121-125