Synthesis of polyhydroxylated piperidines and evaluation as glycosidase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 19, 2004, Pages 5091-5097

  Tite, Tony ^a   Lallemand, Marie Christine ^a   Poupon, Erwan ^a   Kunesch, Nicole ^a   Tillequin, François ^a   Gravier Pelletier, Christine ^b   Merrer, Yves Le ^b   Husson, Henri Philippe ^a  

^a UMR 8638 Associee Au CNRS l'Univ R   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Biological activities; Chiral nonracemic polyhydroxylated piperidines; Glycosidases

Indexed keywords

1 DEOXYNOJIRIMYCIN; 1,2,3 TRIHYDROXY 6 HYDROXYMETHYL 1,2,3,4,6,7,12,12B OCTAHYDROINDOL[3,2 A]QUINAZOLINE 4 CARBONITRILE; ALCOHOL DERIVATIVE; ALPHA GLUCOSIDASE INHIBITOR; ALPHA LEVO FUCOSIDASE; ALPHA MANNOSIDASE; GLYCOSIDASE INHIBITOR; HEXAHYDRO 2 PHENYL 3 METHYL 6,7,8 TRIHYDROXY[2ALPHA,3ALPHA,5BETA,6BETA, 7ALPHA,8BETA,8ABETA] 5H OXAZOLO[3,2 A]PYRIDINE 5 CARBONITRILE; HEXAHYDRO 2 PHENYL 3 METHYL 6,7,8 TRIHYDROXY[2BETA,3BETA,5ALPHA,6BETA, 7ALPHA,8BETA,8ABETA] 5H OXAZOLO[3,2 A]PYRIDINE 5 CARBONITRILE; HEXAHYDRO 3 BENZYL 6,7,8 TRIHYDROXY[3ALPHA,5BETA,6ALPHA,7BETA,8ALPHA, 8ABETA] 5H OXAZOLO[3,2 A]PYRIDINE 5 CARBONITRILE; HEXAHYDRO 3 BENZYL 6,7,8 TRIHYDROXY[3ALPHA,5BETA,6BETA,7ALPHA,8BETA,8ABETA] 5H OXAZOLO[3,2 A]PYRIDINE 5 CARBONITRILE; HEXAHYDRO 3 BENZYLSULFANYLMETHYL 6,7,8 TRIHYDROXY[3ALPHA,5BETA,6ALPHA, 7BETA,8ALPHA,8ABETA] 5H OXAZOLO[3,2 A]PYRIDINE 5 CARBONITRILE; HEXAHYDRO 3 BENZYLSULFANYLMETHYL 6,7,8 TRIHYDROXY[3ALPHA,5BETA,6BETA, 7ALPHA,8BETA,8ABETA] 5H OXAZOLO[3,2 A]PYRIDINE 5 CARBONITRILE; HEXAHYDRO 6,7,8 TRIHYDROXY 3 (1H INDOL 3 METHYL)[3ALPHA,5BETA,6BETA,7ALPHA, 8BETA,8ABETA] 5H OXAZOLO[3,2 A]PYRIDINE 5 CARBONITRILE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITION;

ALPHA-L-FUCOSIDASE; ALPHA-MANNOSIDASE; BACILLUS STEAROTHERMOPHILUS; BACTERIAL PROTEINS; ENZYME INHIBITORS; GLYCOSIDE HYDROLASES; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 4444343348     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.07.039     Document Type: Article

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