New DNA binding ligands as a model of chromomycin A 3

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 19, 2004, Pages 4855-4859

  Imoto, Shuhei ^a,b   Haruta, Yoshinari ^a   Watanabe, Kyouichi ^a   Sasaki, Shigeki ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Chromomycin A 3; DNA minor groove binder

Indexed keywords

CHROMOMYCIN A3; DIMER; DISACCHARIDE; MAGNESIUM; TRISACCHARIDE;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; CHROMATOPHORE; DNA BINDING; STRUCTURE ANALYSIS; THEORETICAL MODEL;

CHROMOMYCIN A3; DIMERIZATION; DNA; LIGANDS; MAGNESIUM;

EID: 4444337382     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.07.043     Document Type: Article

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12. Details will be published soon
13. 1H COSY and NOESY as illustrated in Scheme 1
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18. -1 to CA12. Several attempts to estimate DNA binding by footprinting experiments were not successful so far, probably because of insufficient DNA-binding affinity of 3. Further modification of 3 for higher affinity to DNA is now in progress