Caudal injection of ketorolac is as effective as systemic administration with lower incidence of side effects

Egyptian Journal of Anaesthesia

Volumn 20, Issue 3, 2004, Pages 261-265

  Yosry, Mohammad ^a   Abou Rabia, Fatma A ^a   Nasr, Mohamed A ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Caudal injection; Haemorrhoidectomy; Ketorolac tromethamine; Neuraxial analgesia

Indexed keywords

FENTANYL; KETOROLAC; LIDOCAINE; OXYGEN; PETHIDINE; PROPOFOL;

ACIDITY; ADULT; ANAPHYLAXIS; ANESTHESIA INDUCTION; ARTICLE; CAUDAL ANESTHESIA; CLINICAL PROTOCOL; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; EPIGASTRIC PAIN; FEMALE; GASTROINTESTINAL SYMPTOM; HEMORRHOIDECTOMY; HUMAN; INCIDENCE; KIDNEY DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; PAIN ASSESSMENT; POSTOPERATIVE CARE; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE PAIN; PREOPERATIVE CARE; RANDOMIZED CONTROLLED TRIAL; RASH; THORAX PAIN; VISUAL ANALOG SCALE;

EID: 4444332642     PISSN: 11101849     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Hyllested M, Jones S, Pedersen JL, Kehlet H: Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review. Br J Anaesth 2002;88:199-214.
2. Pickering AE, Bridge HS, Nolan J, Stoddart PA: Double-blind, placebo-controlled analgesic study of ibuprofen or rofecoxib in combination with paracetamol for tonsillectomy in children. Br J Anaesth 2002;88:72-77.
3. Guzman A, Yuste F, Toscano RA, et al.: Absolute configuration of (-)-5-benzoyl-1,2-dihydro-3H-pyrrolo 1,2-alpha]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac. J Med Chem 1986;29:589-591.
4. Cataldo PA, Senagore AJ, Kilbride MJ: Ketorolac and patient conholled analgesia in the treatment of postoperative pain. Surg Gynecol Obstet 1993;176: 435-438.
5. Rappaport JM, Bhatt SM, Burkard RF, et al.: Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac. J Infect Dis 1999;179: 264-268.
6. Forrest JB, Camu F, Greer A et al.: Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery. Br J Anaesth 2002;88:227-233.
7. Mandema JW, Stanski DR: Population pharmacodynamic model for ketorolac analgesia. Clin Pharmacol Ther 1996;60:619-635.
8. McCormack K: Non-steroidal anti-inflammatory drugs and spinal nociceptive processing. Pain 1994;59:9-43.
9. Lauretti GR, Reis MP, Mattos AL, et al.: Epidural nonsteroidal anti-inflammatory drugs for cancer pain. Anesth Analg 1998;89:117-118.
10. Wong CS, Hsu MM, Chou R, et al.: Intrathecal cyclooxygenase inhibitor administration attenuates morphine antinociceptive tolerance in rats. Br J Anaesth 2000;85:747-751.
11. Dunbar SA, Karamov IG, Buerkle H: The effect of spinal ibuprofen on opioid withdrawal in the rat. Anesth Analg 2000;91:417-422.
12. Korkmaz HA, Maltepe F, Erbayraktar S, et al.: Antinociceptive and neurotoxicologic screening of chronic intrathecal administration of ketorolac tromethamine in the rat. Anesth Analg. 2004;98:148-152.
13. Parris WC, Janicki PK, Johnson B Jr, Horn JL: Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat. Can J Anaesth 1996;43:867-870.
14. Eisenach JC, Curry R, Hood DD, Yaksh TL: Phase I safety assessment of intrathecal ketorolac. Pain 2002;99:599-604.
15. Gallivan ST, Johnston SA, Broadstone RV, et al.: The clinical, cerebrospinal fluid, and histopathologic effects of epidural ketorolac in dogs. Vet Surg 2000; 29:436-441
16. Ben-David B, Katz E, Gaitini L, Goldik Z: Comparison of i.m. and local infiltration of ketorolac with and without local anaesthetic. Br J Anaesth 1995;75:409-412.
17. Ben-David B, Baune-Goldstein U, Goldik Z, Gaitini L: Is preoperative ketorolac a useful adjunct to regional anaesthesia for inguinal herniorrhaphy? Acta Anaesthesiol Scand 1996;40:358-363.
18. Dueholm S, Forrest M, Hjortso E, Lemvigh E: Pain relief following herniotomy: a double-blind randomized comparison between naproxen and placebo. Acta Anaesthesiol Scand 1989;33:391-394.
19. Mehlisch DR, Desjardins PJ, Daniels S, Hubbard RC: Single doses of parecoxib sodium intravenously are as effective as ketorolac in reducing pain after oral surgery. J Oral Maxillofac Surg 2003;61:1030-1037.
20. Malmberg AB, Yaksh TL: Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction. Anesthesiology 1993;79:270-281.
21. Lauretti GR, Reis MP, Mattos AL, et al.: Epidural nonsteroidal antiinflammatory drugs for cancer pain. Anesth Analg 1998;86:117-118.
22. Masue T, Dohi S, Asano T, Shimonaka H: Spinal antinociceptive effect of epidural nonsteroidal anti-inflammatory drugs on nitric oxide-induced hyper-algesia in rats. Anesthesiology 1999;91:198-206.
23. Ma W, Eisenach JC: Intraplantar injection of a cyclooxygenase inhibitor ketorolac reduces immunoreactivities of substance P, calcitonin gene-related peptide, and dynorphin in the dorsal horn of rats with nerve injury or inflammation. Neuroscience 2003; 121:681-690.
24. Suresh S, Wheeler M, Patel A: Case series: IV regional anesthesia with ketorolac and lidocaine: is it effective for the management of complex regional pain syndrome 1 in children and adolescents? Anesth Analg 2003;96:694-695.
25. Connelly NR, Reuben SS, Albert M, Page D: Use of preincisional ketorolac in hernia patients: intravenous versus surgical site. Reg Anesth 1997;22:229-232.
26. Bosek V, Cox CE: Comparison of analgesic effect of locally and systemically administered ketorolac in mastectomy patients. Ann Surg Oncol 1996;3:62-66.
27. Coloma M, White PF, Huber PJ Jr, et al: The effect of ketorolac on recovery after anorectal surgery: intravenous versus local administration. Anesth Analg 2000;90:1107-1110.
28. Bjune K, Stublhaug A, Dodgson MS, Breivik H: Additive analgesic effect of codeine and paracetamol can be detected in strong, but not moderate, pain after Caesarean section. Baseline pain-intensity is a determinant of assay-sensitivity in a postoperative analgesic trial. Acta Anaesthesiol Scand 1996;40: 399-407.
29. Collins SL, Moore RA, McQuay HJ: The visual analogue pain intensity scale: what is moderate pain in millimetres? Pain 1997;72:95-97.
30. Buckley MM, Brogden RN: Ketorolac. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential. Drugs 1990;39:86-109.