Effects of megestrol acetate on circulating interleukin-15 and interleukin-18 concentrations in healthy elderly men

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 59, Issue 8, 2004, Pages 855-858

  Lambert, Charles P ^a   Flynn, Michael G ^b   Sullivan, Dennis H ^a   Evans, William J ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 18; MEGESTROL ACETATE; TESTOSTERONE ENANTATE;

ADIPOSE TISSUE; AGED; ARTICLE; BODY COMPOSITION; BODY FAT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HORMONE ACTION; HUMAN; HUMAN EXPERIMENT; MALE; MUSCLE MASS; NORMAL HUMAN; PRIORITY JOURNAL; TRAINING;

EID: 4444331076     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/59.8.m855     Document Type: Article

References (27)

1. Loprinzi CL, Schaid DJ, Dose AM, Bumham NL, Jensen MD. Body-composition changes in patients who gain weight while receiving megestrol acetate. J Clin Oncol. 1993;11:152-154.
2. Von Roenn JH, Armstrong D, Kotler DP, et al. Megestrol acetate in patients with AIDS-related cachexia. Ann Intern Med. 1994;121: 393-399.
3. Tchekmedyian NS, Tait N, Moody M, Aisner J. High-dose megestrol acetate: a possible treatment for cachexia. JAMA. 1987;257:1195-1198.
4. Tchekmedyian NS, Hickman M, Heber D. Treatment of anorexia and weight loss with megestrol acetate in patients with cancer or acquired immunodeficiency syndrome. Semin Oncol. 1991;18:35-42.
5. Tchekmedyian NS, Hickman M, Siau J, et al. Megestrol acetate in cancer anorexia and weight loss. Cancer. 1992;69:1268-1274.
6. Yeh S-S, Wu S-Y, Lee T-P, et al. Improvement in quality-of-life measures and stimulation of weight gain after treatment with megestrol acetate oral suspension in geriatric cachexia: results of a double-blind, placebo-controlled study. J Am Geriatr Soc. 2000;48:485-492.
7. Ciciero LA, Rosenberg JM, Miyashiro A, Maby JI. Megestrol acetate suspension for the treatment of involuntary weight loss in elderly nursing home residents: a retrospective chart review. Consult Pharmacist. 2000;15:811-814.
8. Oster MH, Enders SR, Samuels SJ, et al. Megestrol acetate in patients with AIDS and cachexia. Ann Intern Med. 1994;121:400-408.
9. Lambert CP, Sullivan DH, Freeling SA, Lindquist DM, Evans WJ. Effects of testosterone replacement and/or resistance exercise on the composition of megestrol acetate stimulated weight gain in elderly men: a randomized controlled trial. J Clin Endocrinol Metab. 2002;87: 2100-2106.
10. Salans LB. Influence of progestin and estrogen on far cell size, number, glucose metabolism and insulin sensitivity [Abstract]. Presented at the 53rd Annual Meeting of the Endocrine Society. San Francisco, California, 1971: A59.
11. Steingrimsdottir L, Brasel J, Greenwood MR. Hormonal modulation of adipose tissue lipoprotein lipase may alter food intake in rats. Am J Physiol. 1980;239:E162-E167.
12. Lacasa D, Le Liepvre X, Ferre P, Dugail I. Progesterone stimulates adipocyte determination and differentiation 1/sterol regulatory element-binding protein 1c gene expression. Potential mechanism for the lipogenic effect of progesterone in adipose tissue. J Biol Chem. 2001; 276:11512-11516.
13. Abelenda M, Castro C, Venero C, Puerta M. Reduced oxygen consumption of brown adipocytes isolated from progesterone-treated rats. Can J Physiol Pharmacol. 1994;72:1226-1230.
14. Carbo N, Lopez-Soriano J, Costelli P, et al. Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control. Biochim Biophys Acta. 2001;1526:17-24.
15. Esposito K, Pontillo A, Ciotola M, et al. Weight loss reduces interleukin-18 levels in obese women. J Clin Endocrinol Metab. 2002;87:3864-3866.
16. Alvarez B, Carbo N, Lopez-Soriano J, et al. Effects of interleukin-15 (IL-15) on adipose tissue mass in rodent obesity models: evidence for direct IL-15 action on adipose tissue. Biochim Biophys Acta. 2002; 1570:33-37.
17. Siri WE. Body composition from fluid spaces and density: analysis of method. In: Brozek JHA, ed. Techniques for Measuring Body Composition. Washington, DC: National Academy of Sciences National Research Council; 1961:223-224.
18. Okada H, Nakajima T, Sanezumi M, Ikuta A, Yasuda K, Kanzaki H. Progesterone enhances interleukin-15 production in human endometrial stromal cells in vitro. J Clin Endocrinol Metab. 2000;85:4765-4770.
19. Lambert CP, Sullivan DH, Evans WJ. Effects of testosterone replacement and/or resistance training on interleukin-6, tumor necrosis factor alpha, and leptin in elderly men ingesting megestrol acetate: a randomized controlled trial. J Gerontol Biol Sci Med Sci. 2003;58A: 165-170.
20. Yamashita J, Hideshima T, Shirakusa T, Ogawa M. Medroxyprogesterone acetate treatment reduces serum interleukin-6 levels in patients with metastatic breast carcinoma. Cancer. 1996;78:2346-2352.
21. Kurebayashi J, Yamamoto S, Otsuki T, Sonoo H. Medroxyprogesterone acetate inhibits interleukin 6 secretion from KPL-4 human breast cancer cells both in vitro and in vivo: a possible mechanism of the anticachectic effect. Br J Cancer. 1999;79:631-636.
22. Montes MJ, Tortosa CG, Borja C, et al. Constitutive secretion of interleukin-6 by human decidual stromal cells in culture. Regulatory effect of progesterone. Am J Reprod Immunol. 1995;34:188-194.
23. Miller L, Hunt JS. Regulation of TNF-alpha production in activated mouse macrophages by progesterone. J Immunol. 1998;160:5098-5104.
24. Roubenoff R. Inflammatory and hormonal mediators of cachexia. J Nutr. 1997;127:1014S-1016S.
25. Reyes-Teran G, Sierra-Madero JG, Martinez del Cerro V, et al. Effects of thalidomide on HIV-associated wasting syndrome: a randomized, double-blind, placebo-controlled clinical trial. AIDS. 1996;10:1501-1507.
26. Visser M, Pahor M, Taaffe DR, et al. Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. J Gerontol Med Sci. 2002;57A:M326-M332.
27. Marin P, Lonn L, Andersson B, et al. Assimilation of triglycerides in subcutaneous and intraabdominal adipose tissues in vivo in men: effects of testosterone. J Clin Endocrinol Metab. 1996;81:1018-1022.