Stromal expression of vascular endothelial growth factor correlates with tumor grade and microvessel density in mammary phyllodes tumors: A multicenter study of 185 cases

Human Pathology

Volumn 35, Issue 9, 2004, Pages 1053-1057

  Tse, Gary M K ^a   Lui, Philip C W ^c   Lee, C Soon ^d   Kung, Fred Y L ^a   Scolyer, Richard A ^d   Law, Bonita K B ^a   Lau, Tai Shing ^b   Karim, Rooshdiya ^d   Putti, Thomas C ^e  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNITED CHRISTIAN HOSPITAL   (Hong Kong)

^d UNIVERSITY OF SYDNEY   (Australia)

^e NATIONAL UNIVERSITY HOSPITAL   (Singapore)

Author keywords

angiogenesis; breast; malignancy; vascular endothelial growth factor; VEGF

Indexed keywords

VASCULOTROPIN;

ANGIOGENESIS; BENIGN TUMOR; BREAST TUMOR; CANCER GRADING; CORRELATION ANALYSIS; CYSTOSARCOMA PHYLLOIDES; EPITHELIUM; EPITHELIUM CELL; HISTOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; MICROVASCULATURE; MITOSIS RATE; MORPHOLOGY; PREDICTION; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; REVIEW; STATISTICAL SIGNIFICANCE;

EID: 4444327880     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2004.01.023     Document Type: Article

References (31)

1. Azzopardi J.G. Sarcoma of the breast. Bennington J. Problems in Breast Pathology. Vol II, Major Problems in Pathology. 1979;355-359 Saunders, Philadelphia, PA
2. Palmer M.L., De Risi D.C., Pelikan A., et al. Treatment options and recurrence potential for cystosarcoma phyllodes. Surg Gynecol Obstet. 170:1990;193-196
3. Kario K., Meada S., Mizuno Y., et al.. Phyllodes tumor of the breast A clinocopathologic study of 34 cases. J Surg Oncol. 45:1990;46-51
4. Rowell M.D., Perry R.R., Hsiu J.G., et al. Phyllodes tumors. Am J Surg. 165:1993;376-379
5. Cole-Beuglet C., Soriano R., Kurtz A.B., et al. Ultrasound, X-ray mammography and histopathology of cystosarcoma phyllodes. Radiology. 146:1983;481-486
6. Rosen P.P. Breast Pathology. 2nd ed.:2000;176-197 Lippincott-Raven, Philadelphia
7. Gasparini G. Prognostic value of vascular endothelial growth factor in breast cancer. Oncologist. 5:(suppl 1):2000;37-44
8. Manders P., Beex L.V., Tjan-Heijnen V.C., et al. The prognostic value of vascular endothelial growth factor in 574 node-negative breast cancer patients who did not receive adjuvant systemic therapy. Br J Cancer. 87:2002;772-778
9. Gasparini G., Toi M., Gion M., et al. Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma. J Natl Cancer Inst. 89:1997;139-147
10. Nakamura Y., Yasuoka H., Tsujimoto M., et al. Prognostic significance of vascular endothelial growth factor d in breast carcinoma with long-term follow-up. Clin Cancer Res. 9:2003;716-721
11. Kinoshita J., Kitamura K., Kabashima A., et al. Clinical significance of vascular endothelial growth factor-C (VEGF-C) in breast cancer. Breast Cancer Res Treat. 66:2001;159-164
12. Linderholm B., Grankvist K., Wilking N., et al. Correlation of vascular endothelial growth factor content with recurrences, survival, and first relapse site in primary node-positive breast carcinoma after adjuvant treatment. J Clin Oncol. 18:2000;1423-1431
13. Foekens J.A., Peters H.A., Grebenchtchikov N., et al. High tumor levels of vascular endothelial growth factor predict poor response to systemic therapy in advanced breast cancer. Cancer Res. 61:2001;5407-5414
14. Hasebe T., Imoto S., Sasaki S., et al. Proliferative activity and tumor angiogenesis is closely correlated to stromal cellularity of fibroadenoma Proposal fibroadenoma, cellular variant. Pathol Int. 49:1999;435-443
15. Tse G.M., Lui P.C., Scolyer R.A., et al. Tumour angiogenesis and p53 protein expression in mammary phyllodes tumors. Mod Pathol. 16:2003;1007-1013
16. Linderholm B.K., Lindahl T., Holmberg L., et al. The expression of vascular endothelial growth factor correlates with mutant p53 and poor prognosis in human breast cancer. Cancer Res. 61:2001;2256-2260
17. Yang W., Klos K., Yang Y., et al. ErbB2 overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in human breast carcinoma. Cancer. 94:2002;2855-2861
18. MacConmara M., O'Hanlon D.M., Kiely M.J., et al. An evaluation of the prognostic significance of vascular endothelial growth factor in node positive primary breast carcinoma. Int J Oncol. 20:2002;717-721
19. Valkovic T., Dobrila F., Melato M., et al. Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma. Virchows Arch. 440:2002;583-588
20. Lewis J.S., Landers R.J., Underwood J.C., et al. Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas. J Pathol. 192:2000;150-158
21. Barbera-Guillem E., Nyhus J.K., Wolford C.C., et al. Vascular endothelial growth factor secretion by tumor-infiltrating macrophages essentially supports tumor angiogenesis, and IgG immune complexes potentiate the process. Cancer Res. 62:2002;7042-7049
22. Tse G.M., Ma T.K., Chan K.F., et al. Increased microvessel density in malignant and borderline mammary phyllodes tumours. Histopathology. 38:2001;567-570
23. Linderholm B., Lindh B., Tavelin B., et al. p53 and vascular-endothelial- growth-factor (VEGF) expression predicts outcome in 833 patients with primary breast carcinoma. Int J Cancer. 89:2000;51-62
24. Pal S., Datta K., Mukhopadhyay D. Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma. Cancer Res. 61:2001;6952-6957
25. Bogin L., Degani H. Hormonal regulation of VEGF in orthotopic MCF7 human breast cancer. Cancer Res. 62:2002;1948-1951
26. Kawai H., Li H., Chun P., et al. Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells. Oncogene. 21:2002;7730-7739
27. Buteau-Lozano H., Ancelin M., Lardeux B., et al. Transcriptional regulation of vascular endothelial growth factor by estradiol and tamoxifen in breast cancer cells A complex interplay between estrogen receptors alpha and beta. Cancer Res. 62:2002;4977-4984
28. Ali S.H., O'Donnell A.L., Balu D., et al. Estrogen receptor-alpha in the inhibition of cancer growth and angiogenesis. Cancer Res. 60:2000;7094-7098
29. Wen X.F., Shen Z., Shen Z.Z., et al. The expression of ER beta protein correlates with vascular endothelial growth factor and its prognostic significance in human breast cancer. Oncol Rep. 9:2002;937-944
30. Takei H., Lee E.S., Jordan V.C. In vitro regulation of vascular endothelial growth factor by estrogens and antiestrogens in estrogen-receptor positive breast cancer. Breast Cancer. 9:2002;39-42
31. Heer K., Kumar H., Read J.R., et al. Serum vascular endothelial growth factor in breast cancer Its relation with cancer type and estrogen receptor status. Clin Cancer Res. 7:2001;3491-3494