Temperature: The single most important factor for degradation of glucose fluids during storage

Peritoneal Dialysis International

Volumn 24, Issue 4, 2004, Pages 385-391

  Kjellstrand, Per ^a   Erixon, Martin ^a   Wieslander, Anders ^a   Lindén, Torbjörn ^a   Martinson, Evi ^a  

^a Gambro AB   (Sweden)

Author keywords

3,4 DGE; 3,4 dideoxyglucosone 3 ene; 5 HMF; 5 hydroxymethyl 2 furaldehyde; Bio compatibility; Fluid; Glucose degradation; Glucose degradation products; Heat sterilization; Shelf life; Storage

Indexed keywords

5 HYDROXYMETHYLFURFURAL; GLUCOSE; GLUCOSE DEGRADATION PRODUCT; LACTIC ACID; PERITONEAL DIALYSIS FLUID;

ANIMAL CELL; ARTICLE; BIOCOMPATIBILITY; CELL GROWTH; CELL STRAIN L 929; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEGRADATION; DISINFECTION; FIBROBLAST; GROWTH INHIBITION; HEATING; LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; QUALITY CONTROL; STORAGE; STORAGE TEMPERATURE; SYNTHESIS; TEMPERATURE SENSITIVITY; TIME; ULTRAVIOLET SPECTROSCOPY;

EID: 4444324576     PISSN: 08968608     EISSN: None     Source Type: Journal    
DOI: 10.1177/089686080402400415     Document Type: Article

References (16)

1. Martis L, Henderson LW. Impact of terminal heat sterilization on the quality of peritoneal dialysis solutions. Blood Purif 1997; 15:54-60.
2. Martinson E, Wieslander A, Kjellstrand P, Boberg U. Toxicity of heat sterilized peritoneal dialysis fluids is derived from degradation of glucose. ASAIO J 1992; 38:M370-72.
3. Rippe B, Simonsen O, Heimburger O, Christensson A, Haraadsson B, Stelin G, et al. Long-term clinical effects of peritoneal dialysis fluid with less glucose degradation products. Kidney Int 2001; 59:348-57.
4. Linden T, Musi B, Järkelid L, Forsbäck G, Kjellstrand P, Deppisch R, et al. Glucose degradation products in peritoneal dialysis fluids may have both local and systemic effects: a study of residual fluid and mesothelial cells. Perit Dial Int 2001; 21:607-24.
5. Rippe B, Simonsen O, Wieslander A, Landgren C. Clinical and physiological effects of a new, less toxic and less acidic fluid for peritoneal dialysis. Perit Dial Int 1997; 17:27-34.
6. Simonsen O, Wieslander A, Landgren C, Rippe B. Less infusion pain and elevated level of cancer antigen 125 by the use of a new and more biocompatible PD fluid. Adv Perit Dial 1996; 12:156-60.
7. Lindén T, Forsbäck G, Deppisch R, Henle T, Wieslander A. 3-Deoxyglucosone, a promoter of advanced glycation end products in fluids for peritoneal dialysis. Perit Dial Int 1998; 18:290-3.
8. Nilsson Thorell CB, Muscalu N, Andrén AHG, Kjellstrand P, Wieslander A. Heat sterilization of fluids for peritoneal dialysis gives rise to aldehydes. Perit Dial Int 1993; 13:208-13.
9. Linden T, Arieh C, Deppisch R, Kjellstrand P, Wieslander A. 3,4-Dideoxyglucosone-3-ene (3,4-DGE): a cytotoxic glucose degradation product in fluids for peritoneal dialysis. Kidney Int 2002; 62:697-703.
10. Henderson IS, Couper LA, Lumsden A. The effect of shelf-life of peritoneal dialysis fluid on ultrafiltration in CAPD. In: La Greca G, ed. Peritoneal Dialysis. Milan: Wichtig; 1986: 85-6.
11. Kjellstrand P, Martinson E, Wieslander A, Holmquist B. Development of toxic degradation products during heat sterilization of glucose-containing fluids for peritoneal dialysis: influence of time and temperature. Perit Dial Int 1995; 15:26-32.
12. Wieslander AP, Nordin M, Kjellstrand P, Boberg U. Toxicity of peritoneal dialysis fluids on cultured fibroblasts, L-929. Kidney Int 1991; 40:77-9.
13. Zimmeck A, Tauer A, Fuenfrocken M, Pischetsreider M. How to reduce 3-deoxyglucosone and acetaldehyde in peritoneal dialysis fluids. Perit Dial Int 2002; 22: 350-6.
14. Wieslander AP, Nordin M, Martinson E. Heat sterilized PD fluids impair growth and inflammatory responses of cultured cell lines and human leukocytes. Clin Nephrol 1993; 39:343-8.
15. Kjellstrand P, Martinson E, Wieslander A, Kjellstrand K, Jeppsson E, Svensson E, et al. Degradation in peritoneal dialysis fluids may be avoided by using low pH and high glucose concentration. Perit Dial Int 2001; 21:338-44.
16. Tuncer M, Sarikaya M, Sezer T, Özcan S, Sulenmanlar G, Yakupoglu G, et al. Chemical peritonitis associated with high dialysate acetaldehyde concentrations. Nephrol Dial Transplant 2000; 15:2037-40.