Cellular actions of somatostatin on rat periaqueductal grey neurons in vitro

British Journal of Pharmacology

Volumn 142, Issue 8, 2004, Pages 1273-1280

  Connor, Mark ^a   Bagley, Elena E ^a   Mitchell, Vanessa A ^a   Ingram, Susan L ^b   Christie, MacDonald J ^a   Humphrey, Patrick P A ^c   Vaughan, Christopher W ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b WSU Vancouver ^*  (United States)

^c THERAVANCE INC   (United States)

Author keywords

Analgesia; Calcium current; Opioid; Periaqueductal grey; Potassium current; Somatostatin; Synaptic transmission

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BIM 23027; CALCIUM CHANNEL; CALCIUM ION; CH 275; L 362855; METENKEPHALIN; OPIATE AGONIST; POTASSIUM ION; SOMATOSTATIN; SOMATOSTATIN DERIVATIVE; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CALCIUM CURRENT; CELL ISOLATION; CELL POLARITY; CONTROLLED STUDY; DRUG MECHANISM; EXPERIMENTAL RAT; FEMALE; IN VITRO STUDY; INHIBITORY POSTSYNAPTIC POTENTIAL; MALE; NERVE CELL; NONHUMAN; PATCH CLAMP; PERIAQUEDUCTAL GRAY MATTER; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; RAT; RECORDING;

ANIMALS; FEMALE; MALE; NEURONS; PEPTIDES, CYCLIC; PERIAQUEDUCTAL GRAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN;

EID: 4444321885     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705894     Document Type: Article

References (29)

1. CARLTON, S.M., DU, J., DAVIDSON, E., ZHOU, S. & COGGESHALL, R.E. (2001). Somatostatin receptors on peripheral primary afferent terminals: inhibition of sensitized nociceptors. Pain, 90, 233-244.
2. CHAPMAN, V. & DICKENSON, A.H. (1992). The effects of sandostatin and somatostatin on nociceptive transmission in the dorsal horn of the rat spinal cord. Neuropeptides, 23, 147-152.
3. CHIENG, B. & CHRISTIE, M.J. (1994). Hyperpolarization by opioids acting on μ-receptors of a sub-population of rat periaqueductal gray neurones in vitro. Br. J. Pharmacol., 113, 121-128.
4. CONNOR, M. & CHRISTIE, M.J. (1998). Modulation of calcium channel currents of acutely dissociated rat periaqueductal grey neurons. J. Physiol. (London), 509, 47-58.
5. CORSI, M.M., TICOZZI, C., NETTI, C., FULGENZI, A., TIENGO, M., GAJA, G., GUIDOBONO, F. & FERRERO, M.E. (1997). The effect of somatostatin on experimental inflammation in rats. Anesth. Analg., 85, 1112-1115.
6. DOURNAUD, P., GU, Y.Z., SCHONBRUNN, A., MAZELLA, J., TANNENBAUM, G.S. & BEAUDET, A. (1996). Localization of the somatostatin receptor SST2A in rat brain using a specific anti-peptide antibody. J. Neurosci., 16, 4468-4478.
7. ESCHALIER, A., AUMAITRE, O., ARDID, D., FIALIP, J. & DUCHENE-MARULLAZ, P. (1991). Long-lasting antinociceptive effect of RC-160, a somatostatin analog, in mice and rats. Eur. J. Pharmacol., 199, 119-121.
8. FIELDS, H.L. & BASBAUM, A.I. (1999). Central nervous system mechanisms of pain modulation. In: Textbook of Pain, eds. Wall, P.D. & Melzack, R. pp. 309-329. Edinburgh: Churchill Livingston.
9. HELMCHEN, C., FU, Q.G. & SANDKUHLER, J. (1995). Inhibition of spinal nociceptive neurons by microinjections of somatostatin into the nucleus raphe magnus and the midbrain periaqueductal gray of the anesthetized cat. Neurosci. Lett., 187, 137-141.
10. HELYES, Z., PINTER, E., NEMETH, J., KERI, G., THAN, M., OROSZI, G., HORVATH, A. & SZOLCSANYI, J. (2001). Anti-inflammatory effect of synthetic somatostatin analogues in the rat. Br. J. Pharmacol., 134, 1571-1579.
11. HELYES, Z., THAN, M., OROSZI, G., PINTER, E., NEMETH, J., KERI, G. & SZOLCSANYI, J. (2000). Anti-nociceptive effect induced by somatostatin released from sensory nerve terminals and by synthetic somatostatin analogues in the rat. Neurosci. Lett., 278, 185-188.
12. HEPPELMANN, B. & PAWLAK, M. (1997). Inhibitory effect of somatostatin on the mechanosensitivity of articular afferents in normal and inflamed knee joints of the rat. Pain, 73, 377-382.
13. 2+ channels by G-protein βγ subunits. Nature, 380, 258-262.
14. HERVIEU, G. & EMSON, P.C. (1998). The localization of somatostatin receptor 1 (sst1) immunoreactivity in the rat brain using an N-terminal specific antibody. Neuroscience, 85, 1263-1284.
15. HOYER, D., BELL, G., BERELOWITZ, M., EPELBAUM, J., FENIUK, W., HUMPHREY, P., O'CARROLL, A., PATEL, Y., SCHONBRUNN, A., TAYLOR, J. & REISINE, T. (1995). Classification and nomenclature of somatostatin receptors. Trends Pharm. Sci., 16, 86-88.
16. IKEDA, S.R. (1996). Voltage-dependent modulation of N-type calcium channels by G-protein βγ subunits. Nature, 380, 255-258.
17. 2+ channels in the rat periaqueductal grey neurons by μ-type opioid agonist. J. Neurophysiol., 77, 1418-1424.
18. OSBORNE, P.B., VAUGHAN, C.W., WILSON, H.I. & CHRISTIE, M.J. (1996). Opioid inhibition of rat periaqueductal grey neurones with identified projections to rostral ventromedial medulla in vitro. J. Physiol. (London), 490, 383-389.
19. PINTER, E., HELYES, Z., NEMETH, J., PORSZASZ, R., PETHO, G., THAN, M., KERI, G., HORVATH, A., JAKAB, B. & SZOLCSANYI, J. (2002). Pharmacological characterisation of the somatostatin analogue TT-232: effects on neurogenic and non-neurogenic inflammation and neuropathic hyperalgesia. N-S Arch. Pharmacol., 366, 142-150.
20. SANDKUHLER, J., FU, Q.G. & HELMCHEN, C. (1990). Spinal somatostatin superfusion in vivo affects activity of cat nociceptive dorsal horn neurons: comparison with spinal morphine. Neuroscience, 34, 565-576.
21. SCHINDLER, M., HUMPHREY, P.P. & EMSON, P.C. (1996). Somatostatin receptors in the central nervous system. Prog. Neurobiol., 50, 9-47.
22. SCHINDLER, M., SELLERS, L.A., HUMPHREY, P.P. & EMSON, P.C. (1997). Immunohistochemical localization of the somatostatin SST2(A) receptor in the rat brain and spinal cord. Neuroscience, 76, 225-240.
23. SELMER, I., SCHINDLER, M., ALLEN, J.P., HUMPHREY, P.P. & EMSON, P.C. (2000). Advances in understanding neuronal somatostatin receptors. Reg. Peptides, 90, 1-18.
24. TADDESE, A., NAH, S.Y. & MCCLESKEY, E.W. (1995). Selective opioid inhibition of small nociceptive neurons. Science, 270, 1366-1369.
25. VAUGHAN, C.W. & CHRISTIE, M.J. (1997a). Presynaptic inhibitory action of opioids on synaptic transmission in the rat periaqueductal grey in vitro. J. Physiol. (London), 498, 463-472.
26. VAUGHAN, C.W., CONNOR, M., BAGLEY, E.E. & CHRISTIE, M.J. (2000). Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal grey neurons in vitro. Mol. Pharmacol., 57, 288-295.
27. VAUGHAN, C.W., INGRAM, S.L. & CHRISTIE, M.J. (1997b). Actions of the ORL1 receptor ligand nociceptin on membrane properties of rat periaqueductal grey neurons in vitro. J. Neurosci., 17, 996-1003.
28. VAUGHAN, C.W., INGRAM, S.L., CONNOR, M.A. & CHRISTIE, M.J. (1997c). How opioids inhibit GABA-mediated neurotransmission. Nature, 390, 611-614.
29. ZAMPONI, G.W. & SNUTCH, T.P. (1998). Decay of prepulse facilitation of N type calcium channels during G Protein inhibition is consistent with binding of a single G(βγ) subunit. Proc. Natl. Acad. Sci. U.S.A., 95, 4035-4039.