The role of gamma-aminobutyric acid and glutamate for hypoxic ventilatory response in anesthetized rabbits

Tohoku Journal of Experimental Medicine

Volumn 203, Issue 3, 2004, Pages 219-232

  Yelmen, Nermin Karaturan ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Bicuculline; Control of breathing; GABA; Hypoxia; MK 801

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; BICUCULLINE; DIZOCILPINE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PENTOBARBITAL;

ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREATHING; CHEMORECEPTOR; CONTROLLED STUDY; DENERVATION; DRUG RESPONSE; ELECTRONEUROGRAPHY; HYPOXIA; LATERAL BRAIN VENTRICLE; LUNG CAPACITY; LUNG FUNCTION; NERVE POTENTIAL; NONHUMAN; PHRENIC NERVE; RABBIT; RESPIRATION DEPRESSION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STEREOTAXIS; TIDAL VOLUME;

ADJUVANTS, ANESTHESIA; ANESTHESIA; ANIMALS; ANOXIA; AORTA; CAROTID ARTERIES; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; GLUTAMIC ACID; OXYGEN; PENTOBARBITAL; PHRENIC NERVE; RABBITS; RECEPTORS, N-METHYL-D-ASPARTATE; RESPIRATION;

EID: 4444320906     PISSN: 00408727     EISSN: None     Source Type: Journal    
DOI: 10.1620/tjem.203.219     Document Type: Article

References (37)

1. Anderson, P., Dingledine, R., Gyerstad, L., Langmoen, I. & Mosfeldt Laursen, A. (1980) Two different responses of hippocampal pyramidal cell to aplication of gamma-amino butyric acid. J. Physiol. (Lond)., 305, 279-296.
2. Ang, R.C., Hoop, B. & Kazemi, H. (1992) Role of glutamate as the central neurotransmitter in the hypoxic ventilatory response. J. Appl. Physiol., 72, 1480-1487.
3. Bennet, J.A., Me William, P.N. & Shepheard, S.L. (1987) γ-amino butyric acid-mediated inhibition of neurones in the nucleus tractus solitarius of the cat. J. Physiol. Lond., 392, 417-430.
4. Bureau, M.A., Zinman, R., Foulon, P. & Begin, R. (1984) Diphasic ventilatory response to hypoxia in the newborn Lamb. J. Appl. Physiol., 56, 84-90.
5. Champagnat, J., Denavit-Saubie, M., Moyanova, S. & Rondoum, G. (1982) Involvement of amino acids in periodic inhibitions of bulbar respiratory neurones. Brain Res., 237, 351-365.
6. Chiang, C.H., Pappas, P., Hoop, B. & Kazemi, H. (1986) Central cardiorespiratory effects of glutamate in dogs. J. Appl. Physiol., 60, 2056-2062.
7. Güner, I., Yelmen, N., Sahin, G. & Oruc, T. (2002) The effect of intracerebroventricular dopamine administration on the respiratory response to hypoxia. Tohoku. J. Exp. Med., 196, 219-230.
8. 2 deprivation in the central nervous system. On mechanisms of neuronal response, differential sensitivity and injury. Progress. Neurobiol., 40, 277-318.
9. Haji, A., Takeda, R. & Okazaki, M. (2000) Neuropharmacology of control of respiratory rhythm and pattern in mature mammals. Pharmacol. Ther., 86, 277-304.
10. Hoop, B., Beagle, J.L., Maher, T.J. & Kazemi, H. (1999) Brainstem amino acid neurotransmitters and hypoxic ventilatory response. Respir. Physiol., 118, 117-129.
11. Iversen, K., Hedner, T. & Lundberg, P. (1983) GABA concentrations and turnover in neonatal rat brain during asphyxia and recovery. Acta Physiol. Scand., 118, 91-94.
12. Kalia, M.P. (1981) Anatomical organization of central respiratory neurons. Ann. Rev. Physiol., 43, 105-120.
13. Karaturan, N., Turgut, G., Şahin, G. & Oruç, T. (1996) Response of respiratory control mechanisms to isocapnic sustained moderate hypoxia. Eur. Respir. J., 23, 47.
14. Kazemi, H. & Hoop, B. (1991) Glutamic acid and γ-aminobutyric acid neurotransmitters in central control of breathing. J. Appl. Physiol., 70, 1-7.
15. Kneussl, M.P., Pappagianopoulos, P., Hoop, B. & Kazemi, H. (1986) Reversible depression of ventilation and cardiovascular function by ventriculocisternal perfusion with gamma-aminobutyric acid in dogs. Am. Rev. Respir. Dis., 133, 1024-1028.
16. Lawson, E.E., Richter, D.W., Ballantyne, D. & Lalley, P.M. (1989) Peripheral chemoreceptor inputs to medullary inspiratory and postinspiratory neurons of cats. Pflügers. Archiv., 414, 523-533.
17. Madl, J.E. & Royer, S.M. (2000) Glutamate dependence of GABA levels in neurons of hypoxic and hypoglycemic rat hippocampal slices. Neurosci., 96, 657-664.
18. McCrimmon, O.R., Smith, J.C & Feldman, J.L. (1989) Involvement of excitatory amino acid in neurotransmission of inspiratory drive to spinal respiratory motoneuronal. J. Neurosci., 9, 1910-1921.
19. McCrimmon, D.R., Zuperku, E.J., Hayashi, F., Dogas, Z., Hinrichsen, C.F., Stuth, E.A., Tonkovic-Capin, M., Krolo, M. & Hopp, F.A. (1997) Modulation of the synaptic drive to respiratory premotor and motor neurons. Respir. Physiol., 110, 161-176.
20. Melton, J.E., Neubauer, J.A. & Edelman, N.H. (1990) GABA antagonism reverses hypoxic respiratory depression in the cat. J. Appl. Physiol., 69, 1296-1301.
21. Mizusawa, A., Ogawa, H., Kikuchi, Y., Hida, W., Kurosawa, H., Okabe, S., Takishima, T. & Shirato, K. (1994) Invivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia. J. Physiol., 478, 55-66.
22. Monin, P., Aranda, J., Bansal, R. & Trippenbach, T. (1999) Effect of increased brain GABA concentrations on breathing in unanesthetized newborn rabbits. Biol. Neonate., 76, 168-180.
23. Mueller, R.A., Lundberg, D.B.A., Breese, G.R., Hedner, J., Hedner, T. & Jonason, J. (1982) The neuropharmacology of respiratory control. Pharmacol. Rev., 34, 255-278.
24. Neubauer, J.A., Melton, J.E & Edelman, N.H. (1990) Modulation of respiration during brain hypoxia (Brief review). J. Appl. Physiol., 68, 441-451.
25. Oruç, T., Terzioǧlu, M., Şahin, G. & Dursun, Ş. (1982) Response of central mechanisms to hyperoxia and hypoxia. Bull. Europ. Physiopath. Resp., 18, 439-447.
26. Richter, D.W., Bischoff, A., Anders, K., Bellingham, M. & Windhorst, U. (1991) Response of the medullary respiratory network of the cat to hypoxia. J. Physiol., 443, 231-256.
27. Richter, D.W., Schmidt-Garcon, P., Pierrefiche, O., Bischoff, A.M. & Lalley, P.M. (1999) Neurotransmitters and neuromodulators controlling the hypoxic respiratory response in anaesthetized cats. J. Physiol., 514, 567-578.
28. Robbins, P.A. (1995) Hypoxic ventilatory decline: site of action. J. Appl. Physiol., 79, 373-374.
29. Soto-Arape, I., Burton, M.D. & Kazemi, H. (1995) Central amino acid neurotransmitters and the hypoxic ventilatory response. Am. J. Respir. Crit. Care. Med., 151, 1113-1120.
30. Şahin, G. & Terzioǧlu, M. (1985) The influence of chronic hypoxia on erythrocytic 2, 3-diphosphoglycerate and the sensitivity of peripheral chemoreceptors of rabbits. Cer. Med. Rev., 4, 46-56.
31. Taveira-Da Silva, A.M., Hartley, B., Hamosh, P., Quest, J.A. & Gillis, R. (1987) Respiratory depressant effect of GABA alpha and beta-receptor agonists in the cat. J. Appl. Physiol., 62, 2264-2272.
32. Vizek, M., Pickett, C.K. & Weil, J.V. (1987) Biphasic ventilatory response of adult cats to sustained hypoxia has central origin. J. Appl. Physiol., 63, 1658-1664.
33. 2 and hypoxia after sustained hypoxia in awake cats. J. Appl. Physiol., 76, 2251-2252.
34. Wood, J.D., Watson, W.J. & Drucker, A.J. (1968) The effect of hypoxia on brain gamma-amino butyric acid levels. J. Neurochem., 15, 603-608.
35. Wu, J.Y. (1976) Purification, characterization and kinetic studies of GAD and GABA-T from mouse brain. In: GABA in Nervous System Function, edited by E. Roberts, T. Chase & D. Tower. New York: Raven, pp. 7-55.
36. Yamada, K.A., Hamosh, P. & Gillis, R.A. (1981) Respiratory depression produced by activation of GABA receptors in hindbrain of cat. J. Appl. Physiol., 5, 1278-1286.
37. Yamada, K.A., Norman, W.P., Hamosh, P. & Gillis, R.A. (1982) Medullary ventral surface GABA receptors affect respiratory and cardiovascular function. Brain Res., 248, 71-78.