Does the presence of circulating hepatocellular carcinoma cells indicate a risk of recurrence after resection?

American Journal of Gastroenterology

Volumn 99, Issue 8, 2004, Pages 1503-1509

  Jeng, Kuo Shyang ^b   Sheen, I Shyan ^a   Tsai, Yi Chun ^b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; MESSENGER RNA;

ADULT; AGED; ARTICLE; CANCER RECURRENCE; CANCER RISK; CANCER SURGERY; CANCER SURVIVAL; FEMALE; HUMAN; LIVER CELL CARCINOMA; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY;

ALPHA-FETOPROTEINS; CARCINOMA, HEPATOCELLULAR; DISEASE-FREE SURVIVAL; FEMALE; HEPATECTOMY; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM CIRCULATING CELLS; NEOPLASM RECURRENCE, LOCAL; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 4444307120     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2004.30227.x     Document Type: Article

References (38)

1. Lin TY, Lee CS, Chen KM, et al. Role of surgery in the treatment of primary carcinoma of the liver: A 31-year experience. Br J Surg 1987;74:839-42.
2. Chen MF, Hwang TL, Jeng LB, et al. Postoperative recurrence of hepatocellular carcinoma: Two hundred five consecutive patients who underwent hepatic resection in 15 years. Arch Surg 1994;129:738-42.
3. Jeng KS, Chen BF, Lin HJ. En bloc resection for extensive hepatocellular carcinoma: Is it advisable? World J Surg 1994;18:834-9.
4. Nagasue N, Uchida M, Makino Y, et al. Incidence and factors associated with intrahepatic recurrence following resection of hepatocellular carcinoma. Gastroenterology 1993;105:488-94.
5. Bismuth H, Majno PE, Adam R. Liver transplantation for hepatocellular carcinoma. Semin Liver Dis 1999;19:311-22.
6. Matsumura M, Niwa Y, Hikiba Y, et al. Sensitive assay for detection of hepatocellular carcinoma associated gene transcription (alpha-fetoprotein mRNA) in blood. Biochem Biophys Res Commun 1995;207:813-8.
7. Komeda T, Fukuda Y, Sando T, et al. Sensitive detection of circulating hepatocellular carcinoma cells in peripheral venous blood. Cancer 1995;75:2214-9.
8. Hermanek P, Hutter RV, Sobin LH, et al. International union against cancer. Classification of isolated tumor cells and micrometastasis. Cancer 1999;86:2668-73.
9. Keene SA, Demeure MJ. The clinical significance of micrometastases and molecular metastases. Surgery 2001;129:1-5.
10. Matsumura M, Niwa Y, Kato N, et al. Detection of α-fetoprotein mRNA, an indicator of hematogenous spreading hepatocellular carcinoma, in the circulation: A possible predictor of metastatic hepatocellular carcinoma. Hepatology 1994;20:1418-25.
11. Funaki NO, Tanaka J, Seto SI, et al. Hematogenous spreading of hepatocellular carcinoma cells: Possible participation in recurrence in the liver. Hepatology 1997;25:564-8.
12. Matsumura M, Shiratori Y, Niwa Y, et al. Presence of α-fetoprotein mRNA in blood correlates with outcome in patients with hepatocellular carcinoma. J Hepatol 1999;31:332-9.
13. Okuda N, Nakao A, Takeda S, et al. Clinical significance of alpha-fetoprotein mRNA during perioperative period in HCC. Hepatogastroenterology 1999;46:381-6.
14. Kienle P, Weitz J, Klaes R, et al. Detection of isolated disseminated tumor cells in bone marrow and blood samples of patients with hepatocellular carcinoma. Arch Surg 2000;135:213-8.
15. Goldblatt SA, Nadel EM. Cancer cells in the circulating blood: A critical review. Acta Cytol 1965;9:6-20.
16. Liotta LA, Kleinerman J, Saidel GM. Quantitative relationships of intravascular tumor cells, tumor vessels and pulmonary metastasis following tumor implantation. Cancer Res 1974;34:997-1004.
17. Glaves D. Correlation between circulation cancer cells and incidence of metastases. Br J Cancer 1983;48:665-73.
18. Ijichi M, Takayama T, Matsumura M, et al. α-Fetoprotein mRNA in the circulation as a predictor of postsurgical recurrence of hepatocellular carcinoma: A prospective study. Hepatology 2002;35:853-60.
19. Witzigmann H, Geibler F, Benedix F, et al. Prospective evaluation of circulating hepatocytes by α-fetoprotein messenger RNA in patients with hepatocellular carcinoma. Surgery 2002;131:34-43.
20. Pantel K, Schlimok G, Angstwurm M, et al. Methodological analysis of immunohistochemical screening for disseminated epithelial tumor cells in bone marrow. J Hematother 1994;3:165-73.
21. Fleming ID, Cooper JS, Henson DE, et al. AJCC cancer staging manual, 5th Ed. Philadelphia, PA: Lippincott-Raven, 1997.
22. Greene FL, Page DL, Fleming ID, et al. AJCC cancer staging manual, 6th Ed. New York, NY: Springer-Verlag, 2002.
23. Lemoine A, Le Bricon T, Salvucci M, et al. Prospective evaluation of circulating hepatocytes by alpha-fetoprotein mRNA in humans during liver surgery. Ann Surg 1997;226:43-50.
24. Miyamoto A, Fujiwara Y, Sakon M, et al. Development of a multiple-marker RT-PCR assay for detection of micrometastases of hepatocellular carcinoma. Dig Dis Sci 2000;45:1376-82.
25. Ishikawa T, Kashiwagi H, Iwakami Y, et al. Expression of alpha-fetoprotein and prostate-specific antigen genes in several tissues and detection of mRNAs in normal circulating blood by reverse transcriptase- polymerase chain reaction. Jpn J Clin Oncol 1998;28:723-8.
26. Wong IHN, Lau WY, Leung T, et al. Quantitative comparison of alpha-fetoprotein and albumin mRNA levels in hepatocellular carcinoma/adenoma, non-tumor liver and blood: Implications in cancer detection and monitoring. Cancer Lett 2000;156:141-9.
27. Mori M, Mimori K, Ueo H, et al. Molecular detection of circulating solid carcinoma cells in the peripheral blood: The concept of early systemic disease. Int J Cancer 1996;68:739-43.
28. Yamanaka N, Okamoto E, Fujihara S, et al. Do the tumor cells of hepatocellular carcinomas dislodge into the portal venous stream during hepatic resection? Cancer 1992;70:2263-7.
29. Wong INH, Lau WY, Leung T, et al. Hematogenous dissemination of hepatocytes and tumor cells after surgical resection of hepatocellular carcinoma: A quantitative analysis. Clin Cancer Res 1999;5:4021-7.
30. Ferris JV, Baron RL, Marsh JW, et al. Recurrent hepatocellular carcinoma after liver transplantation: Spectrum of CT findings and recurrence patterns. Radiology 1996;198:233-8.
31. Romsdahl MM, Mcgrath RG, Hoppe E, et al. Experimental model for the study of tumor cells in the blood. Acta Cytol 1965;9:141-5.
32. Glaves D. Metastasis: Reticuloendothelial system and organ retention of disseminated malignant cells. Int J Cancer 1980;26:115-22.
33. Fidler IJ. The biology of human cancer metastasis. 7th Jan Waldenstron lecture. Acta Oncol 1991;30:668-75.
34. Lazarevich NL. Molecular mechanisms of alpha-fetoprotein gene expression. Biochemistry 2000;65:117-33.
35. Louha M, Poussin K, Ganne N, et al. Spontaneous and iatrogenic spreading of liver-derived cells into peripheral blood of patients with primary liver cancer. Hepatology 1997;226:43-50.
36. Qin LX, Tang ZY. The prognostic significance of clinical and pathological features in hepatocellular carcinoma. World J Gastroenterol 2002;8:193-9.
37. Imamura H, Matsuyama Y, Tanaka E, et al. Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol 2003;38:200-7.
38. Hanazaki K, Kajikawa S, Koide N, et al. Prognostic factors after hepatic resection for hepatocellular carcinoma with hepatitis C infection: Univariate and multivariate analysis. Am J Gastroenterol 2001;96:1243-50.