Autoantibodies to citrullinated (poly)peptides: A key diagnostic and prognostic marker for rheumatoid arthritis

Autoimmunity

Volumn 37, Issue 4, 2004, Pages 295-299

  Zendman, Albert J W ^a   Vossenaar, Erik R ^a   van Venrooij, Walther J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CITRULLINE; FILAGGRIN; IMMUNOGLOBULIN M; POLYPEPTIDE; RHEUMATOID FACTOR;

ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; COHORT ANALYSIS; DIAGNOSTIC VALUE; DISEASE ACTIVITY; DISEASE MARKER; HUMAN; PREDICTION; PROGNOSIS; RHEUMATOID ARTHRITIS; SENSITIVITY AND SPECIFICITY;

ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; BIOLOGICAL MARKERS; CITRULLINE; HUMANS; PEPTIDES, CYCLIC;

EID: 4444306315     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.1080/08916930410001708733     Document Type: Article

References (43)

1. Feldmann, M., Brennan, F.M. and Maini, R.N. (1996) "Rheumatoid arthritis", Cell 85, 307-310.
2. Smolen, J.S. and Steiner, G. (2003) "Therapeutic strategies for rheumatoid arthritis", Nat. Rev. Drug Discov. 2, 473-488.
3. O'Dell, J.R. (2002) "Treating rheumatoid arthritis early: a window of opportunity?", Arthritis Rheum. 46, 283-285.
4. Arnett, F.C., Edworthy, S.M., Bloch, D.A., McShane, D.J., Fries, J.F., Cooper, N.S., et al. (1988) "The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis", Arthritis Rheum. 31, 315 -324.
5. van Venrooij, W.J., Hazes, J.M. and Visser, H. (2002) "Anti-citrullinated protein/peptide antibody and its role in the diagnosis and prognosis of early rheumatoid arthritis", Neth. J Med. 60, 383-388.
6. Mageed, R. (1996) "The RF antigen", In: van Venrooij, W.J. and Maini, R.N., eds, Manual of Biological Markers of Disease (Kluwer Academic Publishers, Dordrecht, The Netherlands) 1, Section B 1.1 pp 1-27.
7. van Boekel, M.A., Vossenaar, E.R., van den Hoogen, F.H. and van Venrooij, W.J. (2002) "Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value", Arthritis Rev 4, 87-93.
8. Steiner, G. and Smolen, J. (2002) "Autoantibodies in rheumatoid arthritis and their clinical significance", Arthritis Res. 4(Suppl. 2), SI-S5.
9. Vossenaar, E.R., Zendman, A.J., van Venrooij, W.J. and Pruijn, G.J. (2003) "PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease", Bioessays 25, 1106-1118.
10. Vossenaar, E.R., van Venrooij, W.J. (2004) "Anti-CCP antibodies, a highly specific marker for (early) rheumatoid arthritis", Clin. Appl. Immunol. Rev. 4, 239-262.
11. Nienhuis, R.L. and Mandema, E. (1964) "A new serum factor in patients with rheumatoid arthritis; the antiperinuclear factor (APF ", Ann. Rheum. Dis. 23, 302-305.
12. Young, B.J., Mallya, R.K., Leslie, R.D., Clark, C.J. and Hamblin, T.J. (1979) "Anti-keratin antibodies in rheumatoid arthritis", Br Med. J. 2, 97-99.
13. Sebbag, M., Simon, M., Vincent, C., Masson-Bessière, C., Girbal, E., Durieux, J.J., et al. (1995) "The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies", J. Clin. Investig. 95, 2672-2679.
14. Hoet, R.M., Boerbooms, A.M., Arends, M., Ruiter, D.J. and van Venrooij, W.J. (1991) "Antiperinuclear factor, a marker autoantibody for rheumatoid arthritis: colocalisation of the perinuclear factor and profilaggrin", Ann. Rheum. Dis. 50, 611-618.
15. Nogueira, L., Sebbag, M., Vincent, C., Arnaud, M., Fournie, B., Cantagrel, A., et al. (2001) "Performance of two ELISAs for antifilaggrin autoantibodies, using either affinity purified or deiminated recombinant human filaggrin, in the diagnosis of rheumatoid arthritis", Ann. Rheum. Dis. 60, 882-887.
16. Schellekens, G.A., de Jong, B.A., van den Hoogen, F.H., van de Putte, L.B. and van Venrooij, W.J. (1998) "Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies", J Clin. Investig. 101, 273-281.
17. Girbal-Neuhauser, E., Durieux, J.J., Arnaud, M., Dalbon, P., Sebbag, M., Vincent, C., et al. (1999) "The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues", J. Immunol. 162, 585-594.
18. Vincent, C., Nogueira, L., Sebbag, M., Chapuy-Regaud, S., Arnaud, M., Letourneur, O., et al. (2002) "Detection of antibodies to deiminated recombinant rat filaggrin by enzyme-linked immunosorbent assay: a highly effective test for the diagnosis of rheumatoid arthritis", Arthritis Rheum. 46, 2051-2058.
19. Vittecoq, O., Incaurgarat, B., Jouen-Beades, F., Legoedec, J., Letourneur, O., Rolland, D., et al. (2004) "Autoantibodies recognizing citrullinated rat filaggrin in an ELISA using citrullinated and non-citrullinated recombinant proteins as antigens are highly diagnostic for rheumatoid arthritis", Clin. Exp. Immunol. 135, 173-180.
20. Schellekens, G.A., Visser, H., de Jong, B.A., van den Hoogen, F.H., Hazes, J.M., Breedveld, F.C., et al. (2000) "The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide", Arthritis Rheum. 43, 155-163.
21. Pinheiro, G.C., Scheinberg, M.A., Aparecida da Silva, M. and Maciel, S. (2003) "Anti-cyclic citrullinated peptide antibodies in advanced rheumatoid arthritis", Ann. Intern. Med. 139, 234-235.
22. Vasishta, A. (2002) "Diagnosing early-onset rheumatoid arthritis: the role of anti-CCP antibodies", Am. Clin. Lab. 21, 34-36.
23. Palosuo, T., Tilvis, R., Strandberg, T. and Aho, K. (2003) "Filaggrin related antibodies among the aged", Ann. Rheum. Dis. 62, 261-263.
24. Suzuki, K., Sawada, T., Murakami, A., Matsui, T., Tohma, S., Nakazono, K., et al. (2003) "High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis", Scand. J. Rheumatol. 32, 197-204.
25. Dubucquoi, S., Solau-Gervais, E., Lefranc, D., Marguerie, L., Sibilia, J., Goetz, J., et al. (2004) "Evalution of anti-citrullinated filaggrin antibodies as hallmarks for the diagnosis of rheumatic diseases", Ann. Rheum. Dis. 63, 415-419.
26. Lee, D.M. and Schur, P.H. (2003) "Clinical utility of the anti-CCP assay in patients with rheumatic diseases", Ann. Rheum. Dis. 62, 870-874.
27. Prahalad, S. and Glass, D.N. (2002) "Is juvenile rheumatoid arthritis/juvenile idiopathic arthritis different from rheumatoid arthritis?", Arthritis Res. 4(Suppl 3), 303-310.
28. Mediwake, R., Isenberg, D.A., Schellekens, G.A. and van Venrooij, W.J. (2001) "Use of anti-citrullinated peptide and anti-RA33 antibodies in distinguishing erosive arthritis in patients with systemic lupus erythematosus and rheumatoid arthritis", Ann. Rheum. Dis. 60, 67-68.
29. Wener, M.H., Hutchinson, K., Morishima, C. and Gretch, D.R. (2004) "Antibodies to cyclic citrullinated peptide in sera of patients with hepatitis C virus infection and cryoglobulinemia", Arthritis Rheum. in press.
30. Rantapää-Dahlqvist, S., de Jong, B.A., Berglin, E., Hallmans, G., Wadell, G., Stenlund, H., et al. (2003) "Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis", Arthritis Rheum. 48, 2741-2749.
31. Nielen, M.M., van Schaardenburg, D., Reesink, H.W., van de Stadt, R.J., van der Horst-Bruinsma, I.E., de Koning, M.H., et al. (2004) "Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors", Arthritis Rheum. 50, 380-386.
32. Jansen, AL., van der Horst-Bruinsma, I.E., van Schaardenburg, D., van de Stadt, R.J., de Koning, M.H. and Dijkmans, B.A. (2002) "Rheumatoid factor and antibodies to cyclic citrullinated peptide differentiate rheumatoid arthritis from undifferentiated polyarthritis in patients with early arthritis", J Rheumatol. 29, 2074-2076.
33. van Gaalen, F.A., Linn-Rasker, S.P., van Venrooij, W.J., de Jong, B.A., Breedveld, F.C., Verweij, et al. (2004) "In undifferentiated arthritis autoantibodies to cyclic citrullinated peptides (CCP) predict progression to rheumatoid arthritis: a prospective cohort study", Arthritis Rheum., in press.
34. Visser, H., le Cessie, S., Vos, K., Breedveld, F.C. and Hazes, J.M. (2002) "How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis", Arthritis Rheum. 46, 357-365.
35. Kroot, E.J., de Jong, B.A., van Leeuwen, M.A., Swinkels, H., van den Hoogen, F.H., van't Hof, M., et al. (2000) "The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis", Arthritis Rheum. 43, 1831-1835.
36. van Jaarsveld, C.H., ter Borg, E.J., Jacobs, J.W., Schellekens, G.A., Gmelig-Meyling, F.H., Booma-Frankfort, C., et al. (1999) "The prognostic value of the antipermuclear factor, anti-citrullinated peptide antibodies and rheumatoid factor in early rheumatoid arthritis", Clin. Exp. Rheumatol. 17, 689-697.
37. Jansen, L.M., van Schaardenburg, D., van der Horst-Bruinsma, I.E., van der Stadt, R.J., de Koning, M.H. and Dijkmans, B.A. (2003) "The predictive value of anti-cyclic citrullinated peptide antibodies in early arthritis", J. Rheumatol. 30, 1691-1695.
38. Meyer, O., Labarre, C., Dougados, M., Goupille, P., Cantagrel, A., Dubois, A., et al. (2003) "Anticitrullinated protein/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage", Ann. Rheum. Dis. 62, 120-126.
39. Vencovský, J., Machacek, S., Sedova, L., Kafkova, J., Gatterova, J., Pesakova, V, et al. (2003) "Autoantibodies can be prognostic markers of an erosive disease in early rheumatoid arthritis", Ann. Rheum. Dis. 62, 427-430.
40. Bas, S., Genevay, S., Meyer, O. and Gabay, C. (2003) "Anti-cyclic citrullinated peptide antibodies, IgM and IgA rheumatoid factors in the diagnosis and prognosis of rheumatoid arthritis", Rheumatology (Oxf.) 42, 677 -680.
41. Saraux, A., Berthelot, J.M., Devauchelle, V., Bendaoud, B., Chales, G., Thorel, J.B., et al. (2003) "Value of antibodies to citrulline-containing peptides for diagnosing early rheumatoid arthritis", J. Rheumatol. 30, 2535-2539.
42. Forslind, K., Ahlmén, M., Eberhardt, K., Hafström, I. and Svensson, B. (2004) "Prediction of radiological outcome in early RA in clinical practice: role of antibodies to citrullinated peptides (anti-CCP)", Ann. Rheum. Dis., in press.
43. Kastbom, A., Strandberg, G., Lindroos, A. and Skogh, T. (2004) Anti-CCP antibody test predicts the disease course during three years in early rheumatoid arthritis (the TIRA project)", Ann. Rheum. Dis., in press.