Design and synthesis of a nitrogen mustard derivative stabilized by apo-neocarzinostatin

Journal of Medicinal Chemistry

Volumn 47, Issue 19, 2004, Pages 4710-4715

  Urbaniak, Michael D ^a   Bingham, John P ^b   Hartley, John A ^b   Woolfson, Derek N ^a   Caddick, Stephen ^c  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; ANTINEOPLASTIC ANTIBIOTIC; APOPROTEIN; CHLORAMBUCIL; CHLORMETHINE DERIVATIVE; DNA; GUANINE; HYDROGEN; MELPHALAN; NAPHTHALENE DERIVATIVE; NAPHTHOATE; PROTEIN; UNCLASSIFIED DRUG; ZINOSTATIN CHROMOPHORE;

ARTICLE; CANCER CHEMOTHERAPY; CONJUGATION; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DNA ADDUCT; DNA ALKYLATION; DNA CLEAVAGE; DRUG DESIGN; DRUG STABILITY; DRUG SYNTHESIS; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; INTERCALATION COMPLEX; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STOICHIOMETRY;

ANTINEOPLASTIC AGENTS; BINDING SITES; CHLORAMBUCIL; DNA ADDUCTS; DRUG DESIGN; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MELPHALAN; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITROGEN MUSTARD COMPOUNDS; PROTEIN STRUCTURE, TERTIARY; TAQ POLYMERASE; ZINOSTATIN;

EID: 4444301472     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040790d     Document Type: Article

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