Expression of apoptosis-related proteins Bcl-2 and bax along with transforming growth factor (TGF-β1) in the kidney of patients with glomerulonephritides

Renal Failure

Volumn 26, Issue 4, 2004, Pages 361-367

  Goumenos, Dimitrios S ^a,b   Tsamandas, Athanassios C ^a   Kalliakmani, Pantelitsa ^a   Tsakas, Sotiris ^a   Sotsiou, Florentia ^b   Bonikos, Dionysis S ^a   Vlachojannis, John G ^a  

^a UNIVERSITY HOSPITAL OF PATRAS   (Greece)

^b EVANGELISMOS HOSPITAL   (Greece)

Author keywords

Apoptosis; Bax; Bcl 2; Glomerulonephritis; TGF 1

Indexed keywords

CYTOKINE; DNA FRAGMENT; GROWTH FACTOR; PROTEIN BAX; PROTEIN BCL 2; TRANSFORMING GROWTH FACTOR BETA1;

APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DISEASE COURSE; FEMALE; GLOMERULONEPHRITIS; GLOMERULUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY BIOPSY; KIDNEY COLLECTING TUBULE; KIDNEY DISTAL TUBULE; KIDNEY INJURY; KIDNEY INTERSTITIUM; KIDNEY PROXIMAL TUBULE; KIDNEY SCAR; KIDNEY TUBULE EPITHELIUM; MALE; MORPHOMETRICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASE-CONTROL STUDIES; FEMALE; GLOMERULONEPHRITIS; HUMANS; KIDNEY; MALE; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 4444299708     PISSN: 0886022X     EISSN: None     Source Type: Journal    
DOI: 10.1081/JDI-120039818     Document Type: Article

References (26)

1. Wyllie, A.H. Apoptosis. Review. Br. J. Cancer 1993, 67 (2), 205-208.
2. Orrenius, S. Apoptosis: molecular mechanism and implications for human disease. Review. J. Int. Med. 1995, 237 (6), 529-536.
3. Savill, J. Regulation of glomerular cell number by apoptosis. Kidney Int. 1999, 56 (4), 1216-1222.
4. Shimizu, A.; Kitamura, H.; Masuda, Y.; Ishizaki, M.; Sugisaki, Y.; Yamanaka, N. Apoptosis in the repair process of experimental proliferative glomerulonephritis. Kidney Int. 1995, 47 (1), 114-121.
5. Sugiyama, H.; Kashihara, N.; Makino, H.; Yamasaki, Y.; Ota, Z. Apoptosis in glomerular sclerosis. Kidney Int. 1996, 49 (1), 103-111.
6. Thomas, G.L.; Yang, B.; Wagner, B.; Savill, J.; El Nahas, A.M. Cellular apoptosis and proliferation in experimental renal fibrosis. Nephrol. Dial. Transplant. 1998, 13 (9), 2216-2226.
7. Hammerman, M.R. Growth factors and apoptosis in acute renal injury. Curr. Opin. Nephrol. Hypertens. 1998, 7 (4), 419-424.
8. Amore, A.; Coppo, R. Role of apoptosis in pathogenesis and progression of renal disease. Nephron 2000, 86 (2), 99-104.
9. Hockenbery, D.; Nunez, G.; Milliman, C.; Scheiber, R.; Korsmeyer, S. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990, 348 (6299), 334-336.
10. Lu, Q.L.; Poulson, R.; Wong, L.; Hanby, A.M. Bcl-2 expression in adult and embryonic non-hematopoietic tissues. J. Pathol. 1993, 169 (4), 431-437.
11. Chandler, D.; El-Naggar, A.K.; Brisbay, S.; Redline, R.; McDonnell, T. Apoptosis and expression of the bcl-2 protooncogene in the fetal and adult human kidney: evidence for the contribution of bcl-2 expression to renal carcinogenesis. Human Pathol. 1994, 25 (8), 789-796.
12. Nakopoulou, L.; Stefanaki, K.; Papadakis, J.; Boletis, J.; Zeis, P.M.; Kostakis, A.; Vosnides, G. Expression of bcl-2 oncoprotein in various types of glomerulonephritis and renal allografts. Nephrol. Dial. Transplant. 1996, 11 (6), 997-1002.
13. Oltvai, Z.; Milliman, C.; Korsmeyer, S.J. Bcl-2 heterodimerizes in vivo with a conversed homolog, bax, that accelerates programmed cell death. Cell 1993, 74 (4), 609-619.
14. Yang, E.; Korsmeyer, S. Molecular thanatoptosis: a discourse on the BCL2 family and cell death. Blood 1996, 88 (2), 386-401.
15. Penault-Llorca; Bouabdallah, R.; Devilard, E.; Charton-Bain, M.C.; Hassoun, J.; Birg, F.; Xerri, L. Analysis of bax expression in human tissues using the anti-bax 4F11 monoclonal antibody on paraffin sections. Pathol. Res. Pract. 1998, 194 (7), 457-464.
16. Yoshimura, A.; Uda, S.; Inui, K.; Sugenoya, Y.; Sharif, S.; Yokota, N.; Watanabe, S.; Ideura, T. Expression of bcl-2 and bax in glomerular diseases. Nephrol. Dial. Transplant. 1999, 14 (Suppl. 1), 55-57.
17. Border, W.A.; Noble, N.A. Transforming growth factor beta in tissue fibrosis. N. Engl. J. Med. 1994, 331 (19), 1286-1292.
18. Basile, D.P. The transforming growth factor beta system in kidney disease and repair: recent progress and future directions. Curr. Opin. Nephrol. Hypertens. 1999, 8 (1), 21-30.
19. Williams, M.A.; Lowrie, J.I. Fixation of tissue for morphometric study. In Nephrotoxicity in Experimental and Clinical Situations; Bach, F.H., Lock, E.A., Eds.; Martinus Nijhoff: Dordrecht, 1987;141-166. Part I.
20. Gavrieli, Y.; Sherman, Y.; Ben-Sasson, S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 1992, 119 (3), 493-501.
21. Sorenson, C.M.; Rogers, S.A.; Korsmeyr, S.J.; Hammerman, M.R. Fulminant metanephric apoptosis and abnormal kidney development in bcl-2 deficient mice. Am. J. Physiol. 1995, 268 (1 Pt. 2), F73-F81.
22. Basile, D.P.; Liapis, H.; Hammerman, M.R. Expression of bcl-2 and bax in regenerating rat renal tubules following ischemic injury. Am. J. Physiol. 1997, 272 (5 Pt. 2), F640-F647.
23. Yang, B.; Johnson, T.S.; Thomas, G.L.; Watson, P.F.; Wagner, B.; Skill, N.J.; Haylor, J.L.; El Nahas, A.M. Expression of apoptosis-related genes and proteins in experimental chronic renal scarring. J. Am. Soc. Nephrol. 2001, 12 (2), 275-288.
24. Hockenbery, D.M.; Zutter, M.; Hickey, W.; Nahm, M.; Korsmeyer, S.J. Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci. U. S. A. 1991, 88 (16), 6961-6965.
25. 1 in the kidney and urine of patients with glomerular disease and proteinuria. Nephrol. Dial. Transplant. 2002, 17 (12), 2145-2152.
26. Miyajima, A.; Chen, J.; Lawrence, C.; Ledbetter, S.; Soslow, R.A.; Stern, J.; Jha, S.; Pigato, G.; Lemer, M.L.; Poppas, D.P.; Vaughan, E.D.; Felsen, D. Antibody to transforming growth factor-β ameliorates tubular apoptosis in unilateral ureteral obstruction. Kidney Int. 2000, 58 (6), 2301-2313.