Feasibility of a two-metal, four-purine nucleobase quartet motif

Inorganic Chemistry

Volumn 43, Issue 18, 2004, Pages 5483-5485

  Roitzsch, Michael ^a   Lippert, Bernhard ^a  

^a TU DORTMUND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

9 ETHYLADENINE; 9 METHYLXYPOXANTHINE; ADENINE; ADENINE DERIVATIVE; CATION; DNA BASE; GUANINE; HYPOXANTHINE DERIVATIVE; METAL; NITRATE; NUCLEIC ACID; PLATINUM; PURINE; UNCLASSIFIED DRUG; URACIL; WATER;

ARTICLE; CHEMICAL STRUCTURE; HYDROGEN BOND; MODEL; X RAY CRYSTALLOGRAPHY;

BASE PAIRING; CRYSTALLOGRAPHY, X-RAY; FEASIBILITY STUDIES; HYDROGEN BONDING; MODELS, CHEMICAL; MOLECULAR CONFORMATION; ORGANOPLATINUM COMPOUNDS; PLATINUM; PURINES;

EID: 4444276282     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic0494152     Document Type: Article

References (32)

1. (a) Guschlbauer, W.; Chantot, J. F.; Thiele, D. J. Biomol. Struct. Dyn. 1990, 8, 491-511,
2. (b) Patel, D. J.; Bouaziz, S.; Kettani, A.; Wang Y. In Oxford Handbook of Nucleic Acid Structure; Neidle, S., Ed.; Oxford University Press: Oxford, 1999; pp 389-453.
3. (c) Davis, J. T. Angew. Chem., Int. Ed. 2004, 43, 668-698.
4. Arthanari, H.; Bolton, P. H. Chem. Biol. 2001, 8, 221-230.
5. Parkinson, G. N.; Lee, M. P. H.; Neidle, S. Nature 2002, 417, 876-880.
6. (a) Siddiqui-Jain, A.; Grand, C. L.; Bearss, D. J.; Hurley, L. H. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 11593-11598.
7. (b) Grand, C. L.; Powell, T. J.; Nagle, R. B.; Bearss, D. J.; Tye, D.; Gleason-Guzman, M.; Hurley, L. H. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 6140-6145.
8. Kettani, A.; Gorin, A.; Majumdar, A.; Hermann, T.; Skripkin, E.; Zhao, H.; Jones, R.; Patel, D. J. J. Mol. Biol. 2000, 297, 627-644.
9. Matsugami, A.; Ouhashi, K.; Kanagawa, M.; Liu, H.; Kanagawa, S.; Uesugi, S.; Katahira, M. J. Mol. Biol. 2001, 313, 255-269.
10. Deng, J.; Xiong, Y.; Sundaralingam, M. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 13665-13670.
11. Patel, P. K.; Hosur, R. V. Nucleic Acids Res. 1999, 27, 2457-2464.
12. Cheong, C.; Moore, P. B. Biochemistry 1992, 31, 8406-8414.
13. We are aware that, depending on the size of the metal ion, it may reside either in the plane of the four nucleobases or may be sandwiched between parallel base tetrads.
14. For model compounds, see: (a) Freisinger, E.; Schimanski, A.; Lippert, B. J. Biol. Inorg. Chem. 2001, 6, 378-389.
15. (b) Witkowski, H.; Freisinger, E.; Lippert, B. Chem. Commun. 1997, 1315-1316.
16. (c) Fischer, B.; Preut, H.; Lippert, B.; Schöllhorn, H.; Thewalt, U. Polyhedron 1990, 9, 2199-2204.
17. +", even though this seems unlikely considering the virtual complete lack of basicity of the exocyclic amino group (and delocalization of the lone pair into the heterocyclic ring): Pan, B.; Xiong, Y.; Shi, K.; Deng, D.; Sundarilingam, M. Structure 2003, 11, 815-823.
18. (a) Shiber, M. C.; Braswell, E. H.; Klump, H.; Fresco, J. R. Nucleic Acids Res. 1996, 24, 5004-5013.
19. (b) Murchie, A. I. H.; Lilley, D. M. J. EMBO J. 1994, 13, 993-1001.
20. Hunter, W. N.; Brown T. In Oxford Handbook of Nucleic Acid Structure; Neidle, S., Ed.; Oxford University Press: Oxford, 1999; pp 313-330.
21. 3(A).
22. 2(all data) = 0.0652.
23. Zangrando, E.; Pichierri F.; Randaccia, L.; Lippert, B. Coord. Chem. Rev. 1996, 156, 275-332.
24. 2 of A and N7 of G/Hx are feasible, resulting in diamond-shaped aggregates. See also ref 13b, Figure 8.
25. (a) Rother, I. B.; Freisinger, E.; Erxleben, A.; Lippert, B. Inorg. Chim. Acta 2000, 300-302, 339-352.
26. (b) Roitzsch, M.; Rother, I. B.; Willermann, M.; Erxleben, E.; Costisella, B.; Lippert, B. Inorg. Chem. 2002, 41, 5946-5953.
27. Rother, I. B.; Willermann, M.; Lippert, B. Supramol. Chem. 2002, 14, 189-197.
28. Gu, J.; Leszczynski, J. J. Phys. Chem. A 2000, 104, 1898-1904.
29. syn, see also: Moroni, F.; Famulari, A.; Raimondi, M.; Sabat, M. J. Phys. Chem. B 2003, 107, 4196-4202.
30. anti pairs.
31. (a) Freisinger, E.; Rother, I. B.; Lüth, M. S.; Lippert, B. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 3748-3753.
32. (b) Sigel, R. K. O.; Freisinger, E.; Metzger, S.; Lippert, B. J. Am. Chem. Soc. 1998, 120, 12000-12007.