Influence of organosulphur compounds from garlic on the secretion of matrix metalloproteinases and their Inhibitor TIMP-1 by cultured HUVEC cells

Cell Biology and Toxicology

Volumn 20, Issue 4, 2004, Pages 253-260

  Meyer, K ^a   Ueberham, E ^a   Gebhardt, R ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

diallyl disulphide; HUVEC; matrix metalloproteinase; tissue inhibitor of matrix metalloproteinase 1

Indexed keywords

DIALLYL DISULFIDE; FORSKOLIN; GARLIC EXTRACT; GELATINASE B; MATRIX METALLOPROTEINASE; MESSENGER RNA; ORGANOSULFUR DERIVATIVE; PHORBOL 13 ACETATE 12 MYRISTATE; S ALLYLCYSTEINE; THIOL DERIVATIVE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME RELEASE; ENZYME SYNTHESIS; GARLIC; HUMAN; HUMAN CELL; PRIORITY JOURNAL; UMBILICAL VEIN;

ALLYL COMPOUNDS; CELL SURVIVAL; CELLS, CULTURED; CYSTEINE; DISULFIDES; ENDOTHELIUM, VASCULAR; GARLIC; HUMANS; MATRIX METALLOPROTEINASES; SULFHYDRYL COMPOUNDS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; UMBILICAL VEINS;

ALLIUM SATIVUM;

EID: 4444275584     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:CBTO.0000038463.55930.79     Document Type: Article

References (32)

1. Amagase H, Petesch BL, Matsuura H, Kasuga S, Itakura Y. Intake of garlic and its bioactive components. J Nutr. 2001; 131:955S-62S.
2. Benjamin IJ. Matrix metalloproteinases: from biology to therapeutic strategies in cardiovascular disease. J Investig Med. 2001;49:381-97.
3. Brew K, Dinakarpandian D, Nagase H. Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochim Biophys Acta. 2000;1477:267-83.
4. Celentano DC, Frishman WH. Matrix metalloproteinases and coronary artery disease: a novel therapeutic target. J Clin Pharmacol. 1997;37:991-1000.
5. 2+ increase in the inhibition of intracellular cAMP content. Cell Signal. 1999;11:651-63.
6. Demeule M, Brossard M, Pagé M, Gingras D, Béliveau R. Matrix metalloproteinase inhibiton by green tea catechins. Biochim Biophys Acta. 2000;1478:51-60.
7. Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res. 2002;90:251-62.
8. Gebhardt R, Beck H, Wagner KG. Inhibition of cholesterol biosynthesis by allicin and ajoene in rat hepatocytes and HepG2 cells. Biochim Biophys Acta. 1994;1213:57-62.
9. Gebhardt R. Amplification of palmitate-induced inhibition of cholesterol biosynthesis in cultured rat hepatocytes by garlic-derived allylthiosulfinates. Phytomedicine. 1995;2: 29-34.
10. Gebhardt R, Beck H. Differential inhibitory effects of garlic-derived organosulfides on cholesterol biosynthesis in primary rat hepatocyte cultures. Lipids. 1996;31:1269-76.
11. Gebhardt R. Antioxidative and protective properties of extracts from leaves of the artichoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultured rat hepatocytes. Toxicol Appl Pharmacol. 1997a;144:279-86.
12. Gebhardt R. Garlic: the key to sophisticated lowering of hepatocellular lipid. Nutrition. 1997b;13:379-80.
13. Gebhardt R, Fausel M. Inactivation of lactate dehydrogenase during freezing in the presence of methyrapone: implications for in vitro cytotoxicity studies. In Vitro Mol Toxicol. 2000;13:213-18.
14. George SJ. Therapeutic potential of matrix metalloproteinase inhibitors in atherosclerosis. Exp Opin Invest Drugs. 2000; 9:993-1007.
15. Germain E, Auger J, Ginies C, Siess MH, Teyssier C. In vivo metabolism of diallyl disulfide in the rat: identification of two new metabolites. Xenobiotica. 2002;32:1127-38.
16. Gomez DE, Alonso DF, Yoshiji H, Thorgeirsson UP. Tissue inhibitors of metalloproteinases: structure, regulation and biological functions. Eur J Cell Biol. 1997;74:111-22.
17. Hanemaaijer R, Koolwijk P, Le Clercq L, De Vree WJA, Van Hinsbergh VWM. Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Biochem J. 1993;296:803-9.
18. Hehlgans T, Männel DN. The TNF-TNF receptor system. Biol Chem. 2002;383:1581-5.
19. Van Hinsbergh VWM. Impact of endothelial activation on fibrinolysis and local proteolysis in tissue repair. Ann NY Acad Sci. 1992;667:151-62.
20. Kunz J. Can atherosclerosis regress? The role of the vascular extracellular matrix and the age-related changes of arteries. Gerontology. 2002;48:267-78.
21. Lawson LD. The composition and chemistry of garlic gloves and processed garlic. In: Koch HP, Lawson LD, editors. Garlic: the science and therapeutic application of Allium sativum L. and related species, 2nd edn. Baltimore: Williams & Wilkins. 1996:37-107.
22. Lawson LD. Garlic: a review of its medicinal effects and indicated active compounds. In: Lawson LD, Bauer R, editors. Phytomedicines of Europe. Chemistry and biological activity. Washington, DC: ACS symposium series 691. 1998:176-209.
23. Liu WS, Heckman CA. The sevenfold way of PKC regulation. Cell Signal. 1998;10:529-42.
24. Loftus IM, Naylor AR, Bell PRF, Thompson MM. Matrix metalloproteinases and atherosclerotic plaque instability. Br J Surg. 2002;89:680-94.
25. Luttun A, Dewerchin M, Collen D, Carmeliet P. The role of proteinases in angiogenesis, heart development, restenosis, atherosclerosis, myocardial ischemia and stroke: insights from genetic studies. Curr Atheroscler Rep. 2000;2:407-16.
26. Nagase H, Woessner JF Jr. Matrix metalloproteinases. J Biol Chem. 1999;274:21491-4.
27. Orekhov AN and Grunwald J. Effects of garlic on atherosclerosis. Nutrition. 1997;13:656-63.
28. Reuter HD, Koch HP, Lawson LD. Therapeutic effects and applications of garlic and its preparations. In: Koch HP, Lawson LD, editors. Garlic: The science and therapeutic application of Allium sativum L. and related species, 2nd edn. Baltimore: Williams & Wilkins; 1996:135-212.
29. Shah PK. Plaque disruption and thrombosis: potential role of inflammation and infection. Cardiol Rev. 2000;8:31-9.
30. Ueberham E, Loew R, Ueberham U, Schoenig K, Bujard H. Gebhardt R. Conditional tetracycline-regulated expression of TGF-β1 in liver of transgenic mice leads to reversible intermediary fibrosis. Hepatology. 2003;37:1067-78.
31. Ye S, Humphries S, Henney A. Matrix metalloproteinases: implication in vascular matrix remodelling during atherogenesis. Clin Sci (Lond). 1998;94:103-10.
32. Yeli YY, Liu L. Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies. J Nutr. 2001;131:989S-93S.