Cellular prion protein regulates intracellular hydrogen peroxide level and prevents copper-induced apoptosis

Biochemical and Biophysical Research Communications

Volumn 323, Issue 1, 2004, Pages 218-222

  Nishimura, Takuya ^a   Sakudo, Akikazu ^a   Nakamura, Izuru ^a   Lee, Deug Chan ^a   Taniuchi, Yojiro ^a   Saeki, Keiichi ^a   Matsumoto, Yoshitsugu ^a   Ogawa, Masaharu ^b   Sakaguchi, Suehiro ^b   Itohara, Shigeyoshi ^c   Onodera, Takashi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^c NAGASAKI UNIVERSITY   (Japan)

Author keywords

Cerebellar granular neurons; Copper; Prion protein; PrP deficient mouse

Indexed keywords

CELL PROTEIN; COPPER; HYDROGEN PEROXIDE; PRION PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL DEATH; CELL LEVEL; CELL PROTECTION; CELL STRAIN; CEREBELLUM; CONTROLLED STUDY; FENTON REACTION; KNOCKOUT GENE; METAL BINDING; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; REGULATORY MECHANISM; SENSITIZATION; WILD TYPE;

ANIMALS; APOPTOSIS; CELL NUCLEUS; CELL SURVIVAL; CEREBELLUM; COPPER; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HYDROGEN PEROXIDE; MICE; MICE, INBRED C57BL; NEURONS; PRIONS; PROTEIN BINDING; TIME FACTORS;

EID: 4444266619     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.08.087     Document Type: Article

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