Allogeneic core amino acids of an immunodominant allopeptide are important for MHC binding and TCR recognition

Human Immunology

Volumn 65, Issue 8, 2004, Pages 817-825

  Sitaru, Ana Gabriela ^a   Timmermann, Wolfgang ^b   Ulrichs, Karin ^a   Otto, Christoph ^a,b  

^a Department of Surgery ^*  (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

allograft; alloimmune response; altered peptide ligands; APL; DC; dendritic cells; LEW; Lewis rat; LNC; lymph node cells; major histocompatibility complex; MHC; peptide analogues; T cell receptor; TCR; WF; Wistar Furth rat

Indexed keywords

CHIMERIC PROTEIN; T LYMPHOCYTE RECEPTOR;

ALLOIMMUNITY; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GRAFT REJECTION; IMMUNE RESPONSE; LYMPH NODE CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING, COMPETITIVE; CYTOKINES; HEART TRANSPLANTATION; HISTOCOMPATIBILITY ANTIGENS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HOST VS GRAFT REACTION; IMMUNODOMINANT EPITOPES; ISOANTIGENS; LEUCINE; PEPTIDE MAPPING; PEPTIDES; RATS; RATS, INBRED LEW; RATS, INBRED WF; RECEPTORS, ANTIGEN, T-CELL; TRANSPLANTATION, HOMOLOGOUS;

EID: 4444262716     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2004.05.007     Document Type: Article

References (45)

1. H. Auchincloss, R. Lee, S. Shea, J.S. Markowitz, M.J. Grusby, L.H. Glimcher The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice Proc Natl Acad Sci U S A 90 1993 3373
2. M.H. Sayegh, B. Watschinger, C.B. Carpenter Mechanisms of T cell recognition of alloantigen. The role of peptides Transplantation 57 1994 1295
3. A. Le Moine, M. Goldman, D. Abramowicz Multiple pathways to allograft rejection Transplantation 73 2002 1373
4. D.J. Ross, P.F. Waters, M. Levine, M. Kramer, S. Ruzevich, R.M. Kass Mycophenolate mofetil versus azathioprine immunosuppressive regimens after lung transplantation preliminary experience J Heart Lung Transplant 17 1998 768
5. B.D. Kahan, J. Podbielski, K.L. Napoli, S.M. Katz, H.U. Meier-Kriesche, C.T. Van Buren Immunosuppressive effects and safety of a sirolimus/cyclosporine combination regimen for renal transplantation Transplantation 66 1998 1040
6. A.M. Waaga, A. Chandraker, M. Spadafora-Ferreira, A.R. Iyengar, S.J. Khoury, C.B. Carpenter, M.H. Sayegh Mechanisms of indirect allorecognition characterization of MHC class II allopeptide-specific T helper cell clones from animals undergoing acute allograft rejection Transplantation 65 1998 876
7. K.L. Womer, J.R. Stone, B. Murphy, A. Chandraker, M.H. Sayegh Indirect allorecognition of donor class I and II major histocompatibility complex peptides promotes the development of transplant vasculopathy J Am Soc Nephrol 12 2001 2500
8. N.R. Krieger, Y. DengPing, C.G. Fathman CD4+ but not CD8+ cells are essential for allorecognition J Exp Med 184 1996 2013
9. Z. Liu, A.I. Colovai, S. Tugulea, E.F. Reed, P.E. Fisher, D. Mancini, E.A. Rose, R. Cortesini, R.E. Michler, N. Suciu-Foca Indirect recognition of donor HLA-DR peptides in organ allograft rejection J Clin Invest 98 1996 1150
10. A. Valujskikh, D. Matesic, A. Gilliam, D. Anthony, T.M. Haqqi, P.S. Heeger T cells reactive to a single immunodominant self-restricted allopeptide induce skin graft rejection in mice J Clin Invest 101 1998 1398
11. S.I. Reznik, A. Jaramillo, K.S. SivaSai, K.L. Womer, M.H. Sayegh, E.P. Trulock, G.A. Patterson, T. Mohanakumar Indirect allorecognition of mismatched donor HLA class II peptides in lung transplant recipients with bronchiolitis obliterans syndrome Am J Transplant 1 2001 228
12. G. Benichou, E. Fedoseyeva, P.V. Lehmann, C.A. Olson, H.M. Geysen, M. McMillan, E.E. Sercarz Limited T cell response to donor MHC peptides during allograft rejection. Implications for selective immune therapy in transplantation J Immunol 153 1994 938
13. A. Freese, N. Zavazava HLA-B7 beta-pleated sheet-derived synthetic peptides are immunodominant T-cell epitopes regulating alloresponses Blood 99 2002 3286
14. A.G. Sitaru, W. Timmermann, K. Ulrichs, C. Otto Hierarchical immunogenicity of donor MHC class I peptides in allotransplantation Hum Immunol 63 2002 871
15. A.I. Colovai, Z. Liu, P.E. Harris, R. Cortesini, N. Suciu-Foca Allopeptide-specific T cell reactivity altered by peptide analogs J Immunol 158 1997 48
16. G. Benichou, K.M. Malloy, R.C. Tam, P.S. Heeger, E.V. Fedoseyeva The presentation of self and allogeneic MHC peptides to T lymphocytes Hum Immunol 59 1998 540
17. M. Kozovska, Y.C.Q. Zang, I. Aebischer, S. Lnu, V.M. Trivera, P.D. Crowe, S.A. Boehme, J.Z. Zhang T cell recognition motifs of an immunodominant peptide of myelin basic protein in patients with multiple sclerosis structural requirements and clinical implications Eur J Immunol 28 1998 1894
18. V. Kumar, J.L. Urban, S.J. Horvath, L. Hood Amino acid variations at a single residue in an autoimmune peptide profoundly affect its properties T-cell activation, major histocompatibility complex binding, and ability to block experimental allergic encephalomyelitis Proc Natl Acad Sci U S A 87 1990 1337
19. A.C. Anderson, H. Waldner, V. Turchim, C. Jabs, M.P. Das, V.K. Kurchroo, L.B. Nicholson Autoantigen-responsive T cell clones demonstrate unfocused TCR cross-reactivity toward multiple related ligands implications for autoimmunity Cell Immunol 202 2000 88
20. S.I. Abrams, J. Schlom Rational antigen modification as a strategy to upregulate or downregulate antigen recognition Curr Opin Immunol 12 2000 85
21. D.G. Alleva, A. Gaur, L. Jin, D. Wegmann, P.A. Gottlieb, A. Pahuja, E.B. Johnson, T. Motheral, A. Putnam, P.D. Crowe, N. Ling, S.A. Boehme, P.J. Conlon Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide Diabetes 51 2002 2126
22. E. Zisman, Y. Katz-Levy, M. Dayan, S. Kirshner, M. Paas-Rozner, A. Karni, O. Abramsky, C. Brautbar, M. Fridkin, M. Sela, E. Mozes Peptide analogs to pathogenic epitopes of the human acetylcholine receptor alpha subunit as potential modulators of myasthenia gravis Proc Natl Acad Sci U S A 93 1996 4492
23. B. Bielekova, R. Martin Antigen-specific immunomodulation via altered peptide ligands J Mol Med 79 2001 552
24. P.J. Ruiz, J.J. DeVoss, L.-V.T. Nguyen, P.P. Fontoura, D.L. Hirschberg, D.J. Mitchell, K.C. Garcia, L. Steinman Immunomodulation of experimental autoimmune encephalomyelitis with ordered peptides based on MHC-TCR binding motifs J Immunol 167 2001 2688
25. L. Frasca, A. Tamir, S. Jurcevic, B. Marinari, A. Monizio, R. Sorrentino, M. Carbonari, E. Piccolella, R.I. Lechler, G. Lombardi Peptide analogues as a strategy to induce tolerance in T cells with indirect allospecificity Transplantation 70 2000 631
26. M. Garcia-Peydro, A. Paradela, J.P. Albar, J.A. Castro Antagonism of direct alloreactivity of an HLA-B27-specific CTL clone by altered peptide ligands of its natural epitope J Immunol 165 2000 5680
27. A. Qadri, E.S. Ward Activation of a T cell hybridoma by an alloligand results in differential effects on IL-2 secretion and activation-induced cell death Eur J Immunol 31 2001 3825
28. u)-derived class I peptide Transplantation 66 1998 1059
29. R. Aharoni, D. Teitelbaum, R. Arnon, M. Sela Copolymer 1 acts against the immunodominant epitope 82-100 of myelin basic protein by T cell receptor antagonism in addition to major histocompatibility complex blocking Proc Natl Acad Sci U S A 96 1999 634
30. K. Ono, E.S. Lindsey Improved technique of heart transplantation in rats J Thorac Cardiovasc Surg 57 1969 225
31. R. Obst, N. Netuschil, K. Klopfer, S. Stevanovic, H.G. Rammensee The role of peptides in T cell alloreactivity is determined by self-major histocompatibility molecules J Exp Med 191 2000 805
32. J.P. Vella, C. Magee, L. Vos, K. Womer, H. Rennke, C.B. Carpenter, W. Hancock, M.H. Sayegh Cellular and humoral mechanisms of vascularized allograft rejection induced by indirect recognition of donor MHC allopeptides Transplantation 67 1999 1523
33. J. Sloan-Lancaster, B.D. Evavold, P.M. Allen Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells Nature 363 1993 156
34. A.I. Colovai, E.R. Molajoni, R. Cortesini, N. Suciu-Foca New approaches to specific immunomodulation in transplantation Int Rev Immunol 13 1996 161
35. L.B. Nicholson, J.M. Greer, R.A. Sobel, M.B. Lees, V.K. Kuchroo An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis Immunity 3 1995 397
36. P.D. Crowe, S.A. Boehme, T. Wong, A. Gaur, J. Sidney, A. Sette, P.J. Conlon Differential signaling and hierarchical response thresholds induced by an immunodominant peptide of myelin basic protein and an altered peptide ligand in human T cells Hum Immunol 59 1998 679
37. H.J. Kim, J.P. Antel, P. Duquette, D.G. Alleva, P.J. Conlon, A. Bar-Or Persistence of immune responses to altered and native myelin antigens in patients with multiple sclerosis treated with altered peptide ligand Clin Immunol 104 2002 105
38. H.G. Rammensee, T. Friede, S. Stevanoviic MHC ligands and peptide motifs first listing Immunogenetics 41 1995 178
39. B. Reizis, F. Mor, M. Eisenstein, H. Schild, S. Stefanovic, H.G. Rammensee, I.R. Cohen The peptide binding specificity of the class II I-A molecules of the Lewis rat, RT1 Bl. Int Immunol 12 1996 1825
40. M.H. Wauben, M. van der Kraan, M.C. Grosfeld-Stulemeyer, I. Joosten Definition of an extended MHC class II-peptide binding motif for the autoimmune disease-associated Lewis rat RT1.BL molecule Int Immunol 9 1997 281
41. C. Daniel, A. Grakoui, P.M. Allen Inhibition of an in vitro CD4+ T cell alloresponse using altered peptide ligands J Immunol 160 1998 3244
42. L.R. Soares, P.L. Orr, M.R. Garovoy, G. Benichou Differential activation of T cells by natural antigen peptide analogues influence on autoimmune and alloimmune in vivo T cell responses J Immunol 160 1998 4768
43. M.H. Wauben, A.C. Hoedemaekers, Z.M. Graus, J.P. Wagenaar, W. van Eden, M.H. de Baets Inhibition of experimental autoimmune myasthenia gravis by major histocompatibility complex class II competitor peptides results not only in a suppressed but also in an altered immune response Eur J Immunol 26 1996 2866
44. Y. Katz-Levy, M. Paas-Rozner, S. Kirshner, M. Dayan, E. Zisman, M. Fridkin, I. Wirguin, M. Sela, E. Mozes A peptide composed of tandem analogs of two myasthenogenic T cell epitopes interferes with specific autoimmune responses Proc Natl Acad Sci U S A 94 1997 3200
45. S.M. Anderton, S.P. Manickasingham, C. Burkhart, T.A. Luckuck, S.J. Holland, A.G. Lamont, D.C. Wraith Fine specificity of the myelin-reactive T cell repertoire implications for TCR antagonism in autoimmunity J Immunol 161 1998 3357