Olanzapine increases plasma ghrelin level in patients with schizophrenia

Psychoneuroendocrinology

Volumn 30, Issue 1, 2005, Pages 106-110

  Murashita, Mari ^a   Kusumi, Ichiro ^a   Inoue, Takeshi ^a   Takahashi, Yoshito ^a   Hosoda, Hiroshi ^b   Kangawa, Kenji ^b   Koyama, Tsukasa ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Ghrelin; Mechanism; Neuroendocrinology; Olanzapine; Schizophrenia; Weight gain

Indexed keywords

APPETITE STIMULANT; GASTROINTESTINAL HORMONE; GHRELIN; LEPTIN; OLANZAPINE;

ADULT; AGED; APPETITE; ARTICLE; BODY FAT; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; FEMALE; GLUCOSE METABOLISM; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HORMONE RELEASE; HUMAN; LIPID METABOLISM; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; WEIGHT GAIN;

ADULT; AGED; ANTIPSYCHOTIC AGENTS; APPETITE; BENZODIAZEPINES; BODY COMPOSITION; BODY MASS INDEX; BODY WEIGHT; FEMALE; HUMANS; LEPTIN; MALE; MIDDLE AGED; PEPTIDE HORMONES; RADIOIMMUNOASSAY; SCHIZOPHRENIA; WEIGHT GAIN;

EID: 4444259546     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2004.05.008     Document Type: Article

References (18)

1. H. Ariyasu, K. Takaya, T. Tagami, Y. Ogawa, K. Hosoda, T. Akazumi, M. Suda, T. Koh, K. Natui, S. Toyooka, G. Shirakami, T. Usui, A. Shimatsu, K. Doi, H. Hosoda, M. Kojima, K. Kangawa, and K. Nakao Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans J. Clin. Endocrinol. Metab. 86 2001 4753 5758
2. H. Ariyasu, K. Takaya, H. Hosoda, H. Iwakura, K. Ebihara, K. Mori, Y. Ogawa, K. Hosoda, T. Akamizu, M. Kojima, K. Kangawa, and K. Nakao Delayed short-term secretory regulation of ghrelin in obese animals: evidence by a specific RIA for the active form of ghrelin Endocrinology 143 2002 3341 3350
3. D. Gothelf, B. Falk, P. Singer, M. Kairi, M. Phillip, L. Zigel, I. Poraz, S. Frishman, N. Conatantini, G. Zalsman, A. Weizman, and A. Apter Weight gain associated with increased food intake and low habitual activity levels in male adolescent schizophrenic patients treated with olanzapine Am. J. Psychiatr. 159 2002 1055 1057
4. H. Hosoda, M. Kojima, H. Matuo, and K. Kangawa Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue Biochem. Biophys. Res. Commun. 279 2000 909 913
5. Y. Ito, M. Hagiwara, and G. Yagi Olanzapine therapy and changes in body weight and blood glucose levels among patients with schizophrenia - Interim report of a prospective post-marketing special study of olanzapine conducted in Japan Jpn. J. Clin. Psychopharmacol. 6 2003 1181 1193
6. B. Jones, B.R. Basson, D.J. Walker, A.M. Crawford, and B.J. Kinon Weight change and atypical antipsychotic treatment in patients with schizophrenia J. Clin. Psychiatr. 62 S2 2001 41 44
7. B.J. Kinon, B. Basson, K. Szymanski, and G.D. Tolledon Predictors of weight gain during olanzapine treatment Eur. Neuropsychopharmacol. 8 S2 1998 S220
8. B.J. Kinon, B. Basson, J.A. Gilmore, and G.D. Tollefson Long-term olanzapine treatment: weight change and weight-related health factors in schizophrenia J. Clin. Psychiatr. 62 2001 92 100
9. M. Kojima, H. Hosoda, Y. Date, M. Nakasato, H. Mastuo, and K. Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656 660
10. M. Nakazato, N. Murakami, Y. Date, M. Kojima, H. Matsuo, K. Kangawa, and S. Matsukura A role of ghrelin in the central regulation of feeding Nature 409 2001 194 198
11. M.W. Schwartz, S.C. Woods, D. Porte Jr, R.J. Seeley, and D.G. Baskin Central nervous system control of food intake Nature 404 6778 2000 661 671
12. M. Shintani, Y. Ogawa, K. Ebihara, M. Aizawa-Abe, F. Miyanaga, K. Takaya, T. Hayashi, G. Inoue, K. Hosoda, M. Kojima, K. Kangawa, and K. Nakao Ghrelin, an endogenous growth hormone secreatagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway Diabetes 50 2001 227 232
13. D.M. Taylor, and R. McAskill Atypical antipsychotics and weight gain - a systematic review Acta Psychiatr. Scand. 101 2000 416 432
14. L.H. Tecott, L.M. Sun, and S.F. Akana Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors Nature 374 1995 542 546
15. M. Tschop, D.L. Smiley, and M.L. Heiman Ghrelin induces adiposity in rodents Nature 407 2000 908 913
16. M. Tschop, C. Wayer, P.A. Tataranni, V. Devanarayan, E. Ravussin, and M.L. Heiman Circulating ghrelin levels are decreased in human obesity Diabetes 50 2001 707 709
17. A.M. Wren, C.J. Small, and H.L. Ward The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion Endocrinology 141 2000 4325 4328
18. A.M. Wren, L.J. Seal, M.A. Cohen, A.E. Brynes, G.S. Frost, K.G. Murphy, W.S. Dhillo, M.A. Ghatei, and S.R. Bloom Ghrelin enhances appetite and increases food intake in humans J. Clin. Endocrinol. Metab. 86 12 2001 5992 5995