Increased fetal DNA in the maternal circulation in early pregnancy is associated with an increased risk of preeclampsia

American Journal of Obstetrics and Gynecology

Volumn 191, Issue 2, 2004, Pages 515-520

  Cotter, Amanda M ^a   Martin, Cara M ^a   O'Leary, John J ^a   Daly, Sean F ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Fetal DNA; Preeclampsia

Indexed keywords

DNA;

ADULT; ARTICLE; CIRCULATION; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GENE SEQUENCE; GESTATIONAL AGE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MOLECULAR PROBE; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SYMPTOMATOLOGY;

ADULT; BIOLOGICAL MARKERS; DNA; FEMALE; FETUS; HUMANS; POLYMERASE CHAIN REACTION; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY TRIMESTER, FIRST; RISK; RISK FACTORS; SENSITIVITY AND SPECIFICITY;

EID: 4444252913     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2004.01.040     Document Type: Article

References (22)

1. Dekker G.A., Sibai B.M. Early detection of preeclampsia. Am J Obstet Gynecol. 165:1991;160-172
2. Ness R.B., Roberts J.M. Heterogenous causes constituting the single syndrome of preeclampsia: a hypothesis and its implications. Am J Obstet Gynecol. 175:1996;1365-1370
3. Roberts J.M., Redman C.W.G. Pre-eclampsia: more than pregnancy-induced hypertension. Lancet. 341:1993;1447-1451
4. Holzgreve W., Ghezzi F., Di Naro E., Maymon E., Ganshirt D., Hahn S. Disturbed fetomaternal cell traffic in preeclampsia. Obstet Gynecol. 91:1998;669-672
5. Lo Y.M., Leung T.N., Tein M.S., Sargent I.L., Zhang J., Lau T.K., et al. Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia. Clin Chem. 45:1999;184-188
6. Zhong X.Y., Laivuori H., Livingston J.C., Ylikorkala O., Sibai B.M., Holzgreve W., et al. Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia. Am J Obstet Gynecol. 184:2001;414-419
7. Al-Mufti R., Hambley H., Albaiges G., Lees C., Nicolaides K.H. Increased fetal erythroblasts in women who subsequently develop preeclampsia. Hum Reprod. 15:2000;1624-1628
8. Leung T.N., Zhang J., Lau T.K., Chan L.Y.S., Lo Y.M.D. Increased maternal plasma fetal DNA concentrations in women who eventually develop preeclampsia. Clin Chem. 47:2001;137-139
9. Swinkels D.W., de Kok J.B., Hendriks J.C.M., Wiegerinck E., Zusterzeel P.L.M., Steegers E.A.P. Haemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome as a complication of preeclampsia in pregnant women increases the amount of cell-free fetal and maternal DNA in maternal plasma and serum. Clin Chem. 48:2002;6550-6553
10. Kirke P.N., Molloy A.M., Daly L.E., Burke H., Weir D.G., Scott J.M. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med. 86:1993;703-708
11. Daly L.E., Kirke P.N., Molloy A.M., Weir D.G., Scott J.M. Folate levels and neural tube defects: implications for prevention. JAMA. 274:1995;1698-1702
12. Pertl B., Bianchi D.W. Fetal DNA in maternal plasma: emerging clinical applications. Obstet Gynecol. 98:2001;483-490
13. Lo Y.M.D. Fetal DNA in maternal plasma: biology and diagnostic applications. Clin Chem. 46:2000;1903-1906
14. Bianchi D.W., Williams J.M., Sullivan L.M., Hanson F.W., Klinger K.W., Shuber A.P. PCR quantitation of fetal cells in maternal blood in normal and aneuploid pregnancies. Am J Hum Genet. 61:1997;822-829
15. Bianchi D.W. Fetal cells in the maternal circulation: feasability for prenatal diagnosis. Br J Haematol. 105:1999;574-583
16. Lee T., LeShane E.S., Messerlian G.M., Canick J.A., Farina A., Heber W.W., et al. Down syndrome and cell-free fetal DNA in archived maternal serum. Am J Obstet Gynecol. 187:2002;1217-1221
17. Chua S., Wilkins T., Sargent I., Redman C. Trophoblast deportation in pre-eclamptic pregnancy. Br J Obstet Gynaecol. 98:1991;973-979
18. Sacks G.P., Studena K., Sargent K., Redman C.W.G. Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis. Am J Obstet Gynecol. 179:1998;80-86
19. Redman C.W.G., Sacks G.P., Sargent I.L. Pre-eclampsia: an excessive maternal inflammatory response to pregnancy. Am J Obstet Gynecol. 180:1999;499-506
20. Redman C.W.G., Sargent I.L. Placental debris, oxidative stress and preeclampsia. Placenta. 21:2000;597-602
21. Leung T.N., Smith S.C., To K.F., Sahota D.S., Baker P.N. Increased placental apoptosis in pregnancies complicated by pre-eclampsia. J Soc Gynecol Invest. 6:1999;127A
22. Holzgreve W., Hahn S. Fetal cells in maternal circulation. What is the relationship to obstetric ultrasound? Ultrasound Obstet Gynecol. 17:2001;1-3