Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 19, 2004, Pages 5213-5224

  Sandham, David A ^a   Barker, Lucy ^a   Beattie, David ^a   Beer, David ^a   Bidlake, Louise ^a   Bentley, David ^a   Butler, Keith D ^a   Craig, Sarah ^a   Farr, David ^a   Ffoulkes Jones, Claire ^a   Fozard, John R ^b   Haberthuer, Sandra ^a   Howes, Colin ^a   Hynx, Deborah ^a   Jeffers, Sarah ^a   Keller, Thomas H ^a   Kirkham, Paul A ^a   Maas, Janet C ^a   Mazzoni, Lazzaro ^b   Nicholls, Andrew ^a   Pilgrim, Gaynor E ^a   Schaebulin, Elisabeth ^b   Spooner, Gillian M ^a   Stringer, Rowan ^a   Tranter, Pamela ^a   Turner, Katharine L ^a   Tweed, Morris F ^a   Walker, Christoph ^a   Watson, Simon J ^a   Cuenoud, Bernard M ^b   more..

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Asthma; Duration of action; Glucocorticoids; Side effects

Indexed keywords

9ALPHA CHLORO 17ALPHA [(2,5 DIMETHYL 3 FURANYLCARBONYL)OXY] 6ALPHA FLUORO 11BETA HYDROXY 16ALPHA METHYL 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOXYLIC ACID METHYL ESTER; 9ALPHA CHLORO 17ALPHA [(3,5 DIMETHYL 2 FURANYLCARBONYL)OXY] 6ALPHA FLUORO 11BETA HYDROXY 16ALPHA METHYL 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOXYLIC ACID METHYL ESTER; 9ALPHA CHLORO 17ALPHA [(5 CHLORO 2 FURANYLCARBONYL)OXY] 6 FLUORO 11BETA HYDROXY 16ALPHA METHYL 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOXYLIC ACID METHYL ESTER; 9ALPHA CHLORO 17ALPHA [(5 ETHYL 2 FURANYLCARBONYL)OXY] 6ALPHA FLUORO 11BETA HYDROXY 16ALPHA METHYL 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOXYLIC ACID METHYL ESTER; 9ALPHA CHLORO 6ALPHA FLUORO 11BETA 17ALPHA [(2 METHYL 3 FURANYLCARBONYL)OXY] 16ALPHA METHYL 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOXYLIC ACID METHYL ESTER; 9ALPHA CHLORO 6ALPHA FLUORO 11BETA HYDROXY 16ALPHA METHYL 17ALPHA [(2 FURANYLCARBONYL 5 TRIFLUOROMETHYL)OXY] 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOXYLIC ACID METHYL ESTER; 9ALPHA CHLORO 6ALPHA FLUORO 11BETA HYDROXY 17ALPHA (1 OXOPROPOXY) 16ALPHA METHYL 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOXYLIC ACID METHYL ESTER; 9ALPHA CHLORO 6ALPHA FLUORO 11BETA HYDROXY 17ALPHA [(3 FURANYLCARBONYL 5 METHYL)OXY] 16ALPHA METHYL 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOXYLIC ACID METHYL ESTER; 9ALPHA CHLORO 6ALPHA FLUORO 17ALPHA [(2 FURANYLCARBONYL 3 METHYL)OXY] 11BETA HYDROXY 16ALPHA METHYL 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOXYLIC ACID METHYL ESTER; 9ALPHA CHLORO 6ALPHA FLUORO 17ALPHA [(2 FURANYLCARBONYL 4 METHYL)OXY] 11BETA HYDROXY 16ALPHA METHYL 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOXYLIC ACID METHYL ESTER; 9ALPHA CHLORO 6ALPHA FLUORO 17ALPHA [(2 FURANYLCARBONYL 5 METHYL)OXY] 11BETA HYDROXY 16ALPHA METHYL 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOXYLIC ACID METHYL ESTER; 9ALPHA CHLORO 6ALPHA FLUORO 17ALPHA [(2 FURANYLCARBONYL)OXY] 11BETA HYDROXY 16ALPHA METHYL 3 OXOANDROST 4 ENE 17BETA CARBOXYLIC ACID METHYL ESTER; 9ALPHA CHLORO 6ALPHA FLUORO 17ALPHA [(2 FURANYLCARBONYL)OXY] 11BETA HYDROXY 16ALPHA METHYL 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOTHIOIC ACID (FLUOROMETHYL)ESTER; 9ALPHA CHLORO 6ALPHA FLUORO 17ALPHA [(2 FURANYLCARBONYL)OXY] 11BETA HYDROXY 16ALPHA METHYL 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOXYLIC ACID METHYL ESTER; 9ALPHA CHLORO 6ALPHA FLUORO 17ALPHA [(3 ETHYL 2 FURANYLCARBONYL)OXY] 11BETA HYDROXY 16ALPHA METHYL 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOXYLIC ACID METHYL ESTER; 9ALPHA CHLORO 6ALPHA FLUORO 17ALPHA [(3 FURANYLCARBONYL 4 METHYL)OXY] 11BETA HYDROXY 16ALPHA METHYL 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOXYLIC ACID METHYL ESTER; 9ALPHA CHLORO 6ALPHA FLUORO 17ALPHA [(3 FURANYLCARBONYL)OXY] 11BETA HYDROXY 16ALPHA METHYL 3 OXOANDROSTA 1,4 DIENE 17BETA CARBOXYLIC ACID METHYL ESTER; BUDESONIDE; CORTICOSTEROID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; EOSINOPHILIA; HUMAN; HUMAN CELL; MALE; NONHUMAN; RAT;

ANDROSTENES; ANIMALS; BIOLOGICAL AVAILABILITY; CELL LINE; EOSINOPHILIA; ESTERS; GLUCOCORTICOIDS; HUMANS; MACROPHAGES; ORGAN SIZE; PROTEIN BINDING; RATS; RECEPTORS, GLUCOCORTICOID; STRUCTURE-ACTIVITY RELATIONSHIP; THYMUS GLAND; TUMOR NECROSIS FACTOR-ALPHA;

RODENTIA;

EID: 4444238915     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.06.027     Document Type: Article

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