A Pohlhausen solution for the mass flux from a multi-layered compact in the USP drug dissolution apparatus

Simulation Modelling Practice and Theory

Volumn 12, Issue 6, 2004, Pages 397-411

  Crane, M ^a   Crane, L ^b   Healy, A M ^b   Corrigan, O I ^b   Gallagher, K M ^b   McCarthy, L G ^b  

^a DUBLIN CITY UNIVERSITY   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Boundary layer equations; Drug delivery systems; Mathematical analytical solutions

Indexed keywords

BOUNDARY LAYER EQUATIONS; DRUG DELIVERY SYSTEMS; DRUG DISSOLUTION; MATHEMATICAL/ANALYTICAL SOLUTIONS;

BOUNDARY LAYERS; COMPUTER SIMULATION; DISSOLUTION; DRUG DOSAGE; HYDRODYNAMICS; ROTATION;

MULTILAYERS;

EID: 4444238118     PISSN: 1569190X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.simpat.2004.06.004     Document Type: Article

References (13)

1. Z. Ramtoola, O. Corrigan, Dissolution characteristics of benzoic acid and salicylic acid mixtures in reactive media, Drug Dev. Ind. Pharm. 13 (1987) 1703-1720.
2. W. Higuchi, N. Mir, S. Desai, Dissolution rates of polyphase mixtures, J. Pharm. Sci. 54 (1965) 1405-1410.
3. A.-M. Healy, Investigations of the dissolution mechanisms of acidic drug-excipient compacts, Ph.D. thesis, University of Dublin, Trinity College, 1995.
4. A.-M. Healy, O. Corrigan, The influence of excipient particle size, solubility and acid strength on the dissolution of an acidic drug from two-component compacts, Int. J. Pharm. 143 (1996) 211-221.
5. M. Crane, N. Hurley, L. Crane, A.-M. Healy, O. Corrigan, K. Gallagher, L. McCarthy, Simulation of the USP drug delivery problem using CFD: Experimental, numerical and mathematical aspects, Simul. Model. Pract. Theory. 12 (2004) 147-158.
6. E. Kenny, A moving boundary finite element solution of a pharmaceutical drug delivery problem, Master's thesis, University of Dublin, Trinity College, 1994.
7. C. Vuik, C. Cuvelier, Numerical solution of an etching problem, J. Comput. Phys. 59 (1985) 247-263.
8. J. Crank, Mathematics of diffusion, Oxford University Press, UK, 1975.
9. H. Schlichting, Boundary layer theory, Springer Verlag, Germany, 2000.
10. K. Pohlhausen, Zur Näherungsweise Integration der differentialgleichung der laminaren reibungschicht, ZAMM 1 (1921) 252-268.
11. R. Seban, R. Bond, Skin friction and heat transfer characteristics of a laminar boundary layer on a cylinder in axial flow, J. Aeronautic. Sci. 18 (1951) 671-675.
12. A.-M. Healy, L. McCarthy, K. Gallagher, O. Corrigan, Sensitivity of dissolution rate to location in the paddle dissolution apparatus, J. Pharm. Pharmacol. 54 (3) (2002) 441-444.
13. L. McCarthy, Simulations of hydrodynamics in the paddle dissolution apparatus and dissolution from multi-layered compacts, Ph.D. thesis, University of Dublin, Trinity College, 2002.