Comparison of keratinocyte proliferation in diabetic and non-diabetic inflamed gingiva

Journal of Periodontology

Volumn 75, Issue 7, 2004, Pages 989-994

  Açikgoz, Gökhan ^a   Devrim, Inci ^a   Özdamar, Sükrü ^b  

^a ONDOKUZ MAYIS UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Diabetes mellitus; Gingiva anatomy and physiology; Keratinocytes; Mitosis; Periodontal diseases metabolism

Indexed keywords

AMYLASE; CYCLINE; DNA; FORMALDEHYDE; MONOCLONAL ANTIBODY; PARAFFIN; PEROXIDASE;

ADULT; ARTICLE; BASAL CELL; CALCULATION; CELL PROLIFERATION; CHI SQUARE TEST; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; FEMALE; GINGIVAL BIOPSY; GINGIVITIS; HISTOCHEMISTRY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; INCISION; KERATINIZATION; KERATINOCYTE; MALE; MITOSIS INDEX; MITOSIS RATE; MOUTH MUCOSA; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIODIC ACID SCHIFF STAIN; PERIODONTITIS; PROTEIN EXPRESSION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TISSUE FIXATION;

ADULT; BIOLOGICAL MARKERS; BIOPSY; CASE-CONTROL STUDIES; CELL DIVISION; CHI-SQUARE DISTRIBUTION; DIABETES MELLITUS, TYPE 2; FEMALE; GINGIVA; GINGIVITIS; HUMANS; IMMUNOENZYME TECHNIQUES; KERATINOCYTES; MALE; MITOTIC INDEX; PERIODONTITIS; PROLIFERATING CELL NUCLEAR ANTIGEN;

EID: 4444234240     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2004.75.7.989     Document Type: Article

References (37)

1. Cole AS, Eastoe JE. Biochemistry and Oral Biology. Oxford: Wright; 1998:402-403.
2. Schroeder H, Listgarten MA. The gingival tissues: The architecture of periodontal protection. Periodontol 2000 1997;13:91-120.
3. Lindhe J, Karring T. Anatomy of the periodontium. In: Lindhe J, Karring T, Lang NP, eds. Clinical Periodontology and Implant Dentistry. Copenhagen: Munksgaard; 2002:19-68.
4. Mackenzie IC. Factors influencing the stability of the gingival sulcus. In: Guggenheim B, ed. Periodontology Today. Basel, Switzerland: Karger; 1988:41-49.
5. van Rensburg BGJ. Oral Biology. Chicago: Quintessence Publishing Company; 1995:379-388.
6. Fergusson DB. Oral Bioscience. London: Churchill Livingstone; 1999:100-108.
7. Ross MH, Romrell LJ, Kaye GI. Histology: A Text and Atlas. Baltimore: Williams and Wilkins; 2002:375.
8. Mackenzie IC, Ritman G, Gao Z, Leigh I, Lame EB. Patterns of cytokeratin expression in human gingival epithelia. J Periodontal Res 1991;26:468-478.
9. Mackenzie IC, Gao Z. Patterns of cytokeratin expression in the epithelia of inflamed human gingiva and periodontal pockets. J Periodontal Res 1993;28:49-59.
10. Jarnbring F, Somogyi E, Dalton J, Gustafsson A, Klinge B. Quantitative assessment of apoptotic and proliferative gingival keratinocytes in oral and sulcular epithelium in patients with gingivitis and periodontitis. J Clin Periodontol 2002;29:1065-1071.
11. Itoiz ME, Carranza FA Jr. The gingiva. In: Carranza AF, Newman MG, eds. Clinical Periodontology, 9th ed. Philadelphia: Saunders; 2001:12-19.
12. Barakat NJ, Toto PD, Choukas NC. Aging and cell renewal of oral epithelium. J Periodontol 1969;40:599-602.
13. Iacopino AM. Diabetic periodontitis: Possible lipid-induced defect in tissue repair through alteration of macrophage phenotype and function. Oral Dis 1995;1: 214-219.
14. Grant-Theule DA. Periodontal disease, diabetes, and immune response: A review of current concepts. J West Soc Periodontol Periodontal Abstr 1996;44:69-77.
15. Page RC, Beck JD. Risk assessment for periodontal diseases. Int Dent J 1997;47:61-87.
16. Yigit S, Estrada E. Recurrent necrobiosis lipoidica diabeticorum associated with venous insufficiency in an adolescent with poorly controlled type 2 diabetes mellitus. J Pediatr 2002;141:280-282.
17. Miller DL, Hanson W, Schedl HP, Osborne JW. Proliferation rate and transit time of mucosal cells in small intestine of diabetic rat. Gastroenterology 1977;73: 1326-1332.
18. Hamilton AI, Blackwood HJ. Insulin deficiency and cell proliferation in oral mucosal epithelium of the rat. J Anat 1977;124:757-763.
19. Werner S, Breeden M, Hubner G, Greenhalgh DG, Longaker MT. Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic mouse. J Invest Dermatol 1994;103: 469-473.
20. Casasco A, Casasco M, Calligaro A, Reguzzoni M, Marrone G, Romeo E. Localization of proliferating cell nuclear antigen-immunoreactivity in human dental pulp and gingiva. Bull Group Int Rech Sci Stomatol Odontol 1996;39:81-85.
21. Çelenligil-Nazliel H, Ayhan A, Uzun H, Ruacan S. The effect of age on proliferating cell nuclear antigen expression in oral gingival epithelium of healthy and inflamed human gingiva. J Periodontol 2000;71:1567-1574.
22. Nurmenniemi PK, Pernu HE, Knuuttila ML. Mitotic activity of keratinocytes in nifedipine- and immunosuppressive medication-induced gingival overgrowth. J Periodontol 2001;72:167-173.
23. Hall PA, Levison DA, Woods AL, et al. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 1990;162:285-294.
24. Hume WJ, Potten CS. Advances in epithelial kinetics - an oral view. J Oral Pathol 1979;8:3-22.
25. Kurki P, Vanderlaan M, Dolbeare F, Gray J, Tan EM. Expression of proliferating cell nuclear antigen (PCNA)/cyclin during the cell cycle. Exp Cell Res 1986;166: 209-219.
26. McCormick D, Hall PA. The complexities of proliferating cell nuclear antigen. Histopathology 1992;21: 591-594.
27. Toschi L, Bravo R. Changes in cyclin/proliferating cell nuclear antigen distribution during DNA repair synthesis. J Cell Biol 1988;107:1623-1628.
28. Hall PA, Levison DA. Review: Assessment of cell proliferation in histological material. J Clin Pathol 1990;43: 184-192.
29. Wolf HK, Dittrich KL. Detection of proliferating cell nuclear antigen in diagnostic histopathology. J Histochem Cytochem 1992;40:1269-1273.
30. Nghiem HT, Stahl SS. Mitotic response in basal cells of the crevicular epithelium to gingival surgery. J Periodontol 1979;50:36-37.
31. Marinella MA. Necrobiosis lipoidica diabeticorum. Lancet 2002;360:1143.
32. Tan CK, Castillo C, So AG, Downey KM. An auxiliary protein for DNA polymerase-delta from fetal calf thymus. J Biol Chem 1986;261:12310-12316
33. Bravo R, Frank R, Blundell PA, Macdonald A., Bravo H. Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. Nature 1987;326:515-517
34. Carro OM, Evans SA, Leone CW. Effect of inflammation on the proliferation of human gingival epithelial cells in vitro. J Periodontol 1997;68:1070-1075.
35. Tsuji T, Sasaki K, Kimura Y, Yamada K, Mori M, Shinozaki F. Measurement of proliferating cell nuclear antigen (PCNA) and its clinical application in oral cancers. Int J Oral Maxillofac Surg 1992;21:369-372.
36. Caffesse RG, Kornman KS, Nasjleti CE. The effect of intensive antibacterial therapy on the sulcular environment in monkeys. Part II. Inflammation, mitotic activity and keratinization of the sulcular epithelium. J Periodontol 1980; 51:155-161.
37. McMillan DE. Development of vascular complications in diabetes. Vasc Med 1997;2:132-142.