Hepatotoxicity of isoniazid: A study on the activity of marker enzymes of liver toxicity in serum and liver tissue of rabbits [4]

Indian Journal of Pharmacology

Volumn 36, Issue 4, 2004, Pages 247-249

  Karthikeyan, S ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; DRUG METABOLITE; ISONIAZID; PYRIDOXINE;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; LETTER; LIVER HOMOGENATE; LIVER TOXICITY; MALE; NONHUMAN; RABBIT; TISSUE HOMOGENATE;

EID: 4444230592     PISSN: 02537613     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

References (8)

1. Mitchell JR, Zimmerman HJ, Ishak KG, Thorgiersson UP, Timbrell JA, Snodgrass WR, et al. Isoniazid liver injury: clinical spectrum, pathology and probable pathogenesis. Ann Intern Med 1976;84:181-92.
2. Whitehouse LW, Tryphonas L, Paul CJ, Solomonraj G, Thomas BH, Wong LT. Isoniazid-induced hepatitis steatosis in rabbits: an explanation for susceptibility and its antagonism by pyridoxine hydrochloride. Can J Physiol Pharmacol 1983;61:478-87.
3. Karthikeyan S, Krishnamoorthy MS. Effect of sub acute administration of isoniazid and pyridoxine on lipids in plasma, liver and adipose tissues in the rabbit. Drug Chem Toxicol 1991;14:293-303.
4. Wooten IDP. Microanalysis in medical biochemistry. London WI: J & A Churchill Ltd.; 1964.
5. King J. Practical clinical enzymology. London; D Van Nostrad Co.; 1965.
6. Zar HJ. Biostatistical analysis, Prentice-Hall International, Inc., 1984.
7. Snodgrass W, Potter WZ, Timbrell JA, Jollow DJ, Mitchell JR. Possible mechanism of isoniazid related hepatic injury. Clin Res 1974;22:323.
8. Heisey GB, Hughes HC, Long CM, Rozmiarke H. The guinea pig as a model for isoniazid-induced reactions. Lab Anim Sci 1980;30:42-50.