Pruritus in polycythemia vera is associated with a lower risk of arterial thrombosis

American Journal of Hematology

Volumn 83, Issue 6, 2008, Pages 451-453

  Gangat, Naseema ^a   Strand, Jacob J ^a   Lasho, Terra L ^a   Li, Chin Yang ^a   Pardanani, Animesh ^a   Tefferi, Ayalew ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALLELE; ARTERY THROMBOSIS; ARTICLE; CLINICAL FEATURE; CORRELATION ANALYSIS; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GENE CLUSTER; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; POLYCYTHEMIA VERA; PRIORITY JOURNAL; PRURITUS; RISK FACTOR; SMOKING; VEIN THROMBOSIS;

ADOLESCENT; ADULT; AGED; CHILD; DIABETES MELLITUS; FEMALE; HUMANS; JANUS KINASE 2; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYCYTHEMIA VERA; PREVALENCE; PRURITUS; RETROSPECTIVE STUDIES; RISK FACTORS; SMOKING; THROMBOSIS;

EID: 44349190186     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.21156     Document Type: Article

References (21)

1. Pardanani A, Lasho TL, Finke C, et al. Prevalence and clinicopathologic correlates of JAK2 exon 12 mutations in JAK2V617F-negative polycythemia vera. Leukemia 2007;21:1960-1963.
2. Ganly P, Hanrahan V, Baker B, Romeril K. Identification of JAK2V617F in patients with polycythemia is highly correlated with conventional criteria for diagnosis of polycythemia vera. Am J Hematol 2007;82:80-82.
3. Diehn F, Tefferi A. Pruritus in polycythaemia vera: Prevalence, laboratory correlates and management. Br J Haematol 2001;115:619-621.
4. Vannucchi AM, Antonioli E, Guglielmelli R et al. Clinical profile of homozygous JAK2 617V>F mutation in patients with polycythemia vera or essential thrombocythemia. Blood 2007;110:840-846.
5. Tefferi A, Lasho TL, Schwager SM, et al. The clinical phenotype of wild-type, heterozygous, and homozygous JAK2V617F in polycythemia vera. Cancer 2006;106:631-635.
6. Vannucchi AM, Antonioli E, Guglielmelli P, et al. Prospective identification of high-risk polycythemia vera patients based on JAK2(V617F) allele burden. Leukemia 2007;21:1952-1959.
7. Tefferi A, Strand JJ, Lasho TL, et al. Bone marrow JAK2V617F allele burden and clinical correlates in polycythemia vera. Leukemia 2007;21:2074-2075.
8. Gangat N, Strand J, Li CY, et al. Leucocytosis in polycythaemia vera predicts both inferior survival and leukaemic transformation. Br J Haematol 2007;138:354-358.
9. Lasho TL, Mesa R, Gilliland DG, Tefferi A. Mutation studies in CD3+, CD19+ and CD34+ cell fractions in myeloproliferative disorders with homozygous JAK2(V617F) in granulocytes. Br J Haematol 2005;130:797-799.
10. Landolfi R, Marchioli R, Kutti J, et al. Efficacy and safety of low-dose aspirin in polycythemia vera. N Engl J Med 2004;350:114-124.
11. Koch CA, Lasho TL, Tefferi A. Platelet-rich plasma serotonin levels in chronic myeloproliferative disorders: Evaluation of diagnostic use and comparison with the neutrophil PRV-1 assay. Br J Haematol 2004;127:34-39.
12. Racke K, Schworer H, Simson G. Effects of cigarette smoking or ingestion of nicotine on platelet 5-hydroxytryptamine (5-HT) levels in smokers and non-smokers. Clin Invest 1992;70:201-204.
13. Barradas MA, Gill DS, Fonseca VA, et al. Intraplatelet serotonin in patients with diabetes mellitus and peripheral vascular disease. Eur J Clin Invest 1988;18:399-404.
14. Weisshaar E, Apfelbacher C, Jager G, et al. Pruritus as a leading symptom: Clinical characteristics and quality of life in German and Ugandan patients. Br J Dermatol 2006,155:957-964.
15. Steinhoff M, Bienenstock J, Schmelz M, et al. Neurophysiological, neuroimmunological, and neuroendocrine basis of pruritus. J Invest Dermatol 2006;126:1705-1718.
16. Tefferi A, Fonseca R. Selective serotonin reuptake inhibitors are effective in the treatment of polycythemia vera-associated pruritus. Blood 2002;99: 2627.
17. Buchanan JG, Ameratunga RV, Hawkins RC. Polycythemia vera and water-induced pruritus: Evidence against mast cell involvement. Pathology 1994;26:43-45.
18. Steinman HK, Kobza-Black A, Lotti TM, et al. Polycythaemia rubra vera and water-induced pruritus: Blood histamine levels and cutaneous fibrinolytic activity before and after water challenge. Br J Dermatol 1987;116:329-333.
19. Jackson N, Burt D, Crocker J, Boughton B. Skin mast cells in polycythaemia vera: Relationship to the pathogenesis and treatment of pruritus. Br J Dermatol 1987;116:21-29.
20. Vardiman JW, Brunning RD, Harris NL.WHO histological classification of chronic myeloproliferative diseases. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. World Health Organization Classification of Tumors: Tumours of the Haematopoietic and Lymphoid Tissues. Lyon, France: International Agency for Research on Cancer (IARC) Press; 2001. pp 17-44.
21. Levine RL, Belisle C, Wadleigh M, et al. X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoiesis. Blood 2006;107:4139-4141.