Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol

European Journal of Pharmaceutical Sciences

Volumn 34, Issue 2-3, 2008, Pages 110-117

  Kumpulainen, Hanna ^a   Järvinen, Tomi ^a   Mannila, Anne ^a   Leppänen, Jukka ^a   Nevalainen, Tapio ^a   Mäntylä, Antti ^a   Vepsäläinen, Jouko ^a   Rautio, Jarkko ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Acetaldehyde; Ethyl dioxy phosphate; Formaldehyde; Phosphatase; Prodrug

Indexed keywords

ACETALDEHYDE; ALKALINE PHOSPHATASE; BUFFER; ETHYL DIOXYPHOSPHATE; FORMALDEHYDE; FOSPROPOFOL; PRODRUG; PROPOFOL; PROPOFOL PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ALKALINE PHOSPHATASE; ANESTHETICS, INTRAVENOUS; ANIMALS; BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; HYDROLYSIS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PHOSPHATES; PRODRUGS; PROPOFOL; RATS; RATS, WISTAR; SOLUBILITY; SOLUTIONS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 44349181958     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2008.02.121     Document Type: Article

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