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Volumn 275, Issue 12, 2008, Pages 3193-3206

Implication of the glutamine synthetase/glutamate synthase pathway in conditioning the amino acid metabolism in bundle sheath and mesophyll cells of maize leaves

Author keywords

Amino acid translocation; Compartmentation; Glutamine and glutamate synthesis; Nitrogen assimilation; Zea mays L

Indexed keywords

ASPARTATE AMMONIA LIGASE; FERREDOXIN NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE REDUCTASE; FERREDOXIN NITRITE REDUCTASE; GLUTAMATE AMMONIA LIGASE; GLUTAMATE DEHYDROGENASE (NADP); GLUTAMATE SYNTHASE (NADH); ISOPROTEIN; NITRATE REDUCTASE (NADH);

EID: 44349174230     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2008.06472.x     Document Type: Article
Times cited : (30)

References (54)
  • 1
    • 0000569341 scopus 로고
    • 4 photosynthesis plants formulated from comparative studies with Digitaria sanguinalis (L.) Scop
    • 4 photosynthesis plants formulated from comparative studies with Digitaria sanguinalis (L.) Scop. Plant Physiol 64, 309 313.
    • (1979) Plant Physiol , vol.64 , pp. 309-313
    • Moore, R.1    Black, C.J.2
  • 2
    • 0001862072 scopus 로고
    • Molecular cloning of the family of glutamine synthetase genes from maize: Expression of genes for glutamine synthetase and ferredoxin-dependent glutamate synthase in photosynthetic and non-photosynthetic tissues
    • Sakakibara H, Kawabata S, Takahashi H, Hase T Sugiyama T (1992) Molecular cloning of the family of glutamine synthetase genes from maize: expression of genes for glutamine synthetase and ferredoxin-dependent glutamate synthase in photosynthetic and non-photosynthetic tissues. Plant Cell Physiol 33, 49 58.
    • (1992) Plant Cell Physiol , vol.33 , pp. 49-58
    • Sakakibara, H.1    Kawabata, S.2    Takahashi, H.3    Hase, T.4    Sugiyama, T.5
  • 4
    • 0038011612 scopus 로고    scopus 로고
    • p1 in maize (Zea mays)
    • p1 in maize (Zea mays). J Plant Physiol 160, 601 605.
    • (2003) J Plant Physiol , vol.160 , pp. 601-605
    • Muhitch, M.J.1
  • 6
    • 0019044034 scopus 로고
    • 4 species Zea mays: Sources of ATP and NADPH and the contribution of photosystem II
    • 4 species Zea mays: sources of ATP and NADPH and the contribution of photosystem II. Arch Biochem Biophys 202, 330 341.
    • (1980) Arch Biochem Biophys , vol.202 , pp. 330-341
    • Chapman, K.S.R.1    Berry, J.A.2    Hatch, M.D.3
  • 7
    • 0005584965 scopus 로고    scopus 로고
    • The Arabidopsis circadian system
    • In. Somerville, C. Meyerowitz, E., eds. pp. The American Society of Plant Biologists, Rockville.
    • McClung CR, Salomé PA Michael TP (2002) The Arabidopsis circadian system. In The Arabidopsis Book (Somerville C Meyerowitz E, eds pp. 1 23. The American Society of Plant Biologists, Rockville.
    • (2002) The Arabidopsis Book , pp. 1-23
    • McClung, C.R.1    Salomé, P.A.2    Michael, T.P.3
  • 8
    • 0001148079 scopus 로고
    • Sources, fluxes, and sinks of nitrogen during early reproductive growth of maize (Zea mays L.)
    • Crawford TW Jr, Rendig VV Broadbent FE (1982) Sources, fluxes, and sinks of nitrogen during early reproductive growth of maize (Zea mays L.). Plant Physiol 70, 1654 1660.
    • (1982) Plant Physiol , vol.70 , pp. 1654-1660
    • Crawford Jr., T.W.1    Rendig, V.V.2    Broadbent, F.E.3
  • 9
    • 16644372819 scopus 로고    scopus 로고
    • Amino acid metabolism in maize earshoots. Implications for assimilate reconditioning and nitrogen signaling
    • Seebauer JR, Moose SP, Fabbri BJ, Crossland LD Below FE (2004) Amino acid metabolism in maize earshoots. Implications for assimilate reconditioning and nitrogen signaling. Plant Physiol 136, 4326 4334.
    • (2004) Plant Physiol , vol.136 , pp. 4326-4334
    • Seebauer, J.R.1    Moose, S.P.2    Fabbri, B.J.3    Crossland, L.D.4    Below, F.E.5
  • 10
    • 0036010144 scopus 로고    scopus 로고
    • The role of glutamine synthetase and glutamate dehydrogenase in nitrogen assimilation and possibilities for improvement in the nitrogen utilization of crops
    • Miflin BJ Habash DZ (2002) The role of glutamine synthetase and glutamate dehydrogenase in nitrogen assimilation and possibilities for improvement in the nitrogen utilization of crops. J Exp Bot 53, 979 987.
    • (2002) J Exp Bot , vol.53 , pp. 979-987
    • Miflin, B.J.1    Habash, D.Z.2
  • 11
    • 0001293070 scopus 로고
    • + assimilation in Zea mays. Preliminary studies with a glutamate dehydrogenase (GDH1) null mutant
    • + assimilation in Zea mays. Preliminary studies with a glutamate dehydrogenase (GDH1) null mutant. Plant Physiol 94, 647 656.
    • (1990) Plant Physiol , vol.94 , pp. 647-656
    • Magalhães, J.R.1    Ju, G.C.2    Rich, P.J.3    Rhodes, D.4
  • 12
    • 0028890906 scopus 로고
    • Evidence that glutamate dehydrogenase plays a role in the oxidative deamination of glutamate in seedlings of Zea mays
    • Stewart GR, Shatilov VR, Turnbull MH, Robinson SA Goodall R (1995) Evidence that glutamate dehydrogenase plays a role in the oxidative deamination of glutamate in seedlings of Zea mays. Aust J Plant Physiol 22, 805 809.
    • (1995) Aust J Plant Physiol , vol.22 , pp. 805-809
    • Stewart, G.R.1    Shatilov, V.R.2    Turnbull, M.H.3    Robinson, S.A.4    Goodall, R.5
  • 14
    • 33846342194 scopus 로고    scopus 로고
    • Tobacco isoenzyme 1 of NAD(H)-dependent glutamate dehydrogenase catabolizes glutamate in vivo
    • Purnell MP Botella JR (2007) Tobacco isoenzyme 1 of NAD(H)-dependent glutamate dehydrogenase catabolizes glutamate in vivo. Plant Physiol 143, 530 539.
    • (2007) Plant Physiol , vol.143 , pp. 530-539
    • Purnell, M.P.1    Botella, J.R.2
  • 15
    • 0033765590 scopus 로고    scopus 로고
    • Reciprocal diurnal changes of phosphoenolpyruvate carboxylase expression and cytosolic pyruvate kinase, citrate synthase and NADP-isocitrate dehydrogenase expression regulate organic acid and metabolism during nitrate assimilation in tobacco leaves
    • Scheible W-R, Krapp A Stitt M (2000) Reciprocal diurnal changes of phosphoenolpyruvate carboxylase expression and cytosolic pyruvate kinase, citrate synthase and NADP-isocitrate dehydrogenase expression regulate organic acid and metabolism during nitrate assimilation in tobacco leaves. Plant Cell Environ 23, 1155 1167.
    • (2000) Plant Cell Environ , vol.23 , pp. 1155-1167
    • Scheible, W.-R.1    Krapp, A.2    Stitt, M.3
  • 16
    • 0003398353 scopus 로고
    • Effects of light/dark cycle on expression of nitrate assimilatory genes in maize shoots and roots
    • Bowsher CG, Long DM, Oaks A Rothstein SJ (1991) Effects of light/dark cycle on expression of nitrate assimilatory genes in maize shoots and roots. Plant Physiol 95, 281 285.
    • (1991) Plant Physiol , vol.95 , pp. 281-285
    • Bowsher, C.G.1    Long, D.M.2    Oaks, A.3    Rothstein, S.J.4
  • 17
    • 0036664567 scopus 로고    scopus 로고
    • Diurnal changes in ammonia assimilation in transformed tobacco plants expressing ferredoxin-dependent glutamate synthase mRNA in the antisense orientation
    • Ferrario-Méry S, Valadier M-H, Godefroy N, Miallier D, Hirel B, Foyer CH Suzuki A (2002) Diurnal changes in ammonia assimilation in transformed tobacco plants expressing ferredoxin-dependent glutamate synthase mRNA in the antisense orientation. Plant Sci 163, 59 67.
    • (2002) Plant Sci , vol.163 , pp. 59-67
    • Ferrario-Méry, S.1    Valadier, M.-H.2    Godefroy, N.3    Miallier, D.4    Hirel, B.5    Foyer, C.H.6    Suzuki, A.7
  • 18
    • 1842462559 scopus 로고    scopus 로고
    • Transcriptome of Arabidopsis leaf senescence
    • Guo Y, Cai Z Gan S (2004) Transcriptome of Arabidopsis leaf senescence. J Exp Bot 27, 521 549.
    • (2004) J Exp Bot , vol.27 , pp. 521-549
    • Guo, Y.1    Cai, Z.2    Gan, S.3
  • 19
    • 0032213203 scopus 로고    scopus 로고
    • Reciprocal regulation of distinct asparagine synthetase genes by light and metabolites in Arabidopsis thaliana
    • Lam H-M, Hsieh MH Coruzzi GM (1998) Reciprocal regulation of distinct asparagine synthetase genes by light and metabolites in Arabidopsis thaliana. Plant J 16, 345 353.
    • (1998) Plant J , vol.16 , pp. 345-353
    • Lam, H.-M.1    Hsieh, M.H.2    Coruzzi, G.M.3
  • 20
    • 33748053006 scopus 로고    scopus 로고
    • Salinity-induced tissue-specific diurnal changes in nitrogen assimilatory enzymes in tomato seedlings under high or low nitrate medium
    • Debouba M, Gouia H, Valadier M-H, Ghorbel MH Suzuki A (2006) Salinity-induced tissue-specific diurnal changes in nitrogen assimilatory enzymes in tomato seedlings under high or low nitrate medium. Plant Physiol Biochem 44, 409 419.
    • (2006) Plant Physiol Biochem , vol.44 , pp. 409-419
    • Debouba, M.1    Gouia, H.2    Valadier, M.-H.3    Ghorbel, M.H.4    Suzuki, A.5
  • 21
    • 2642676517 scopus 로고
    • Nitrogen metabolism in the stalk tissue of maize
    • Ta CT (1991) Nitrogen metabolism in the stalk tissue of maize. Plant Physiol 97, 1375 1380.
    • (1991) Plant Physiol , vol.97 , pp. 1375-1380
    • Ta, C.T.1
  • 23
    • 33645960112 scopus 로고    scopus 로고
    • Functional differentiation of bundle sheath and mesophyll maize chloroplasts determined by comparative proteomics
    • Majeran W, Cai Y, Sun Q van Wijk KJ (2005) Functional differentiation of bundle sheath and mesophyll maize chloroplasts determined by comparative proteomics. Plant Cell 17, 3111 3140.
    • (2005) Plant Cell , vol.17 , pp. 3111-3140
    • Majeran, W.1    Cai, Y.2    Sun, Q.3    Van Wijk, K.J.4
  • 24
    • 15044353209 scopus 로고    scopus 로고
    • Glutamate synthase: Structural, mechanistic and regulatory properties, and role in amino acid metabolism
    • Suzuki A Knaff DB (2005) Glutamate synthase: structural, mechanistic and regulatory properties, and role in amino acid metabolism. Photosynth Res 83, 191 217.
    • (2005) Photosynth Res , vol.83 , pp. 191-217
    • Suzuki, A.1    Knaff, D.B.2
  • 25
    • 33644836833 scopus 로고    scopus 로고
    • Three maize leaf ferredoxin:NADPH oxidoreductases vary in subchloroplast location, expression, and interaction with ferredoxin
    • Okutani S, Hanke GT, Satomi Y, Takao T, Kurisu G, Suzuki A Hase T (2005) Three maize leaf ferredoxin:NADPH oxidoreductases vary in subchloroplast location, expression, and interaction with ferredoxin. Plant Physiol 139, 1451 1459.
    • (2005) Plant Physiol , vol.139 , pp. 1451-1459
    • Okutani, S.1    Hanke, G.T.2    Satomi, Y.3    Takao, T.4    Kurisu, G.5    Suzuki, A.6    Hase, T.7
  • 27
    • 0037255010 scopus 로고    scopus 로고
    • + oxidoreductase to nitrate and light in maize leaves
    • + oxidoreductase to nitrate and light in maize leaves. J Plant Physiol 160, 65 70.
    • (2003) J Plant Physiol , vol.160 , pp. 65-70
    • Sakakibara, H.1
  • 28
  • 29
    • 0001389312 scopus 로고
    • Subcellular and immunocytochemical localization of the enzymes involved in ammonia assimilation in mesophyll and bundle-sheath cells of maize leaves
    • Becker TW, Perrot-Rechenmann C, Suzuki A Hirel B (1993) Subcellular and immunocytochemical localization of the enzymes involved in ammonia assimilation in mesophyll and bundle-sheath cells of maize leaves. Planta 191, 129 136.
    • (1993) Planta , vol.191 , pp. 129-136
    • Becker, T.W.1    Perrot-Rechenmann, C.2    Suzuki, A.3    Hirel, B.4
  • 31
    • 0005234311 scopus 로고
    • Effects of methionine sulfoximine and glycine on nitrogen metabolism of maize leaves in the light
    • Berger MG Fock HP (1983) Effects of methionine sulfoximine and glycine on nitrogen metabolism of maize leaves in the light. Aust J Plant Physiol 10, 187 194.
    • (1983) Aust J Plant Physiol , vol.10 , pp. 187-194
    • Berger, M.G.1    Fock, H.P.2
  • 32
    • 0000500127 scopus 로고
    • Vascular bundle-specific localization of cytosolic glutamine synthetase in rice leaves
    • Kamachi K, Yamaya T, Hayakawa T, Mae T Ojima T (1992) Vascular bundle-specific localization of cytosolic glutamine synthetase in rice leaves. Plant Physiol 99, 1481 1486.
    • (1992) Plant Physiol , vol.99 , pp. 1481-1486
    • Kamachi, K.1    Yamaya, T.2    Hayakawa, T.3    Mae, T.4    Ojima, T.5
  • 33
    • 0002677794 scopus 로고
    • Differential biogenesis of photosystem II in mesophyll and bundle-sheath cells of monocotyledonous NADP-malic enzyme-type C4 plants: The non-stoichiometric abundance of the subunits of photosystem II in the bundle-sheath chloroplasts and the translational activity of the plastome-encoded genes
    • Meierhoff K Westhoff P (1993) Differential biogenesis of photosystem II in mesophyll and bundle-sheath cells of monocotyledonous NADP-malic enzyme-type C4 plants: the non-stoichiometric abundance of the subunits of photosystem II in the bundle-sheath chloroplasts and the translational activity of the plastome-encoded genes. Planta 191, 23 33.
    • (1993) Planta , vol.191 , pp. 23-33
    • Meierhoff, K.1    Westhoff, P.2
  • 34
    • 2642694340 scopus 로고
    • Polarographic study of ammonia assimilation by isolated chloroplasts
    • Anderson JW Done J (1977) Polarographic study of ammonia assimilation by isolated chloroplasts. Plant Physiol 60, 504 508.
    • (1977) Plant Physiol , vol.60 , pp. 504-508
    • Anderson, J.W.1    Done, J.2
  • 36
    • 0033777345 scopus 로고    scopus 로고
    • Analysis of reductant supply systems for ferredoxin-dependent sulfite reductase in photosynthetic and non-photosynthetic organs of maize
    • Yonekura-Sakakibara K, Onda Y, Ashikari T, Tanaka Y, Kusumi T Hase T (2000) Analysis of reductant supply systems for ferredoxin-dependent sulfite reductase in photosynthetic and non-photosynthetic organs of maize. Plant Physiol 122, 887 894.
    • (2000) Plant Physiol , vol.122 , pp. 887-894
    • Yonekura-Sakakibara, K.1    Onda, Y.2    Ashikari, T.3    Tanaka, Y.4    Kusumi, T.5    Hase, T.6
  • 37
    • 0009033886 scopus 로고
    • Immunocytolocalization of ferredoxin-GOGAT in the cells of green leaves and cotyledons of Lycopersicon esculentum
    • Bottela JR, Verbelen JP Valpuesta V (1988) Immunocytolocalization of ferredoxin-GOGAT in the cells of green leaves and cotyledons of Lycopersicon esculentum. Plant Physiol 87, 255 257.
    • (1988) Plant Physiol , vol.87 , pp. 255-257
    • Bottela, J.R.1    Verbelen, J.P.2    Valpuesta, V.3
  • 38
    • 0000761339 scopus 로고    scopus 로고
    • In vitro reconstitution of electron transport from glucose-6-phosphate and NADPH to nitrite
    • Jin T, Huppe HC Turpin DH (1998) In vitro reconstitution of electron transport from glucose-6-phosphate and NADPH to nitrite. Plant Physiol 117, 303 309.
    • (1998) Plant Physiol , vol.117 , pp. 303-309
    • Jin, T.1    Huppe, H.C.2    Turpin, D.H.3
  • 39
    • 33845336120 scopus 로고    scopus 로고
    • A second isoform of the ferredoxin:NADP oxidoreductase generated by an in-frame initiation of translation
    • Thomas J-C, Ughy B, Lagoutte B Ajliani G (2006) A second isoform of the ferredoxin:NADP oxidoreductase generated by an in-frame initiation of translation. Proc Natl Acad Sci USA 103, 18368 18373.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 18368-18373
    • Thomas, J.-C.1    Ughy, B.2    Lagoutte, B.3    Ajliani, G.4
  • 40
    • 0037928225 scopus 로고
    • Phytochrome-mediated phototropism in maize mesocotyls. Relation between light and Pfr gradients, light growth response and phototropism
    • Kunzelmann P Schäfer E (1985) Phytochrome-mediated phototropism in maize mesocotyls. Relation between light and Pfr gradients, light growth response and phototropism. Planta 165, 424 429.
    • (1985) Planta , vol.165 , pp. 424-429
    • Kunzelmann, P.1    Schäfer, E.2
  • 41
    • 0006874650 scopus 로고
    • Adenine nucleotide levels, the redox state of the NADP system, and assimilatory force in nonaqueously purified mesophyll chloroplasts from maize leaves under different light intensities
    • Usuda H (1988) Adenine nucleotide levels, the redox state of the NADP system, and assimilatory force in nonaqueously purified mesophyll chloroplasts from maize leaves under different light intensities. Plant Physiol 88, 1461 1468.
    • (1988) Plant Physiol , vol.88 , pp. 1461-1468
    • Usuda, H.1
  • 42
    • 85014510753 scopus 로고
    • Localization of nitrite and sulfite reductase in bundle sheath and mesophyll cells of maize leaves
    • Sclimutz D Brunold C (1985) Localization of nitrite and sulfite reductase in bundle sheath and mesophyll cells of maize leaves. Physiol Plant 64, 523 528.
    • (1985) Physiol Plant , vol.64 , pp. 523-528
    • Sclimutz, D.1    Brunold, C.2
  • 44
    • 0000482954 scopus 로고
    • Grain protein accumulation and the relationship between leaf nitrate reductase and protease activities during grain development in maize (Zea mays L.). I. Variation between genotypes
    • Reed AJ, Below FE Hagement R (1980) Grain protein accumulation and the relationship between leaf nitrate reductase and protease activities during grain development in maize (Zea mays L.). I. Variation between genotypes. Plant Physiol 66, 164 170.
    • (1980) Plant Physiol , vol.66 , pp. 164-170
    • Reed, A.J.1    Below, F.E.2    Hagement, R.3
  • 45
    • 0020400997 scopus 로고
    • Genetic control of nitrogen assimilation in bacteria
    • Magasanik B (1982) Genetic control of nitrogen assimilation in bacteria. Annu Rev Genet 16, 135 168.
    • (1982) Annu Rev Genet , vol.16 , pp. 135-168
    • Magasanik, B.1
  • 46
    • 0034671553 scopus 로고    scopus 로고
    • A new class of glutamate dehydrogenases (GDH). Biochemical and generic characterization of the first member, the AMP-requiring NAD-specific GDH of Streptomyces clavuligerus
    • Minambres B, Olivera ER, Jensen RA Luengo JM (2000) A new class of glutamate dehydrogenases (GDH). Biochemical and generic characterization of the first member, the AMP-requiring NAD-specific GDH of Streptomyces clavuligerus. J Biol Chem 275, 39529 39542.
    • (2000) J Biol Chem , vol.275 , pp. 39529-39542
    • Minambres, B.1    Olivera, E.R.2    Jensen, R.A.3    Luengo, J.M.4
  • 47
    • 0006095742 scopus 로고
    • P plastidial localization and origin of l-glutamate dehydrogenase in a soybean cell culture
    • Bhadula SK Shargool PD (1991) P plastidial localization and origin of l-glutamate dehydrogenase in a soybean cell culture. Plant Physiol 95, 258 263.
    • (1991) Plant Physiol , vol.95 , pp. 258-263
    • Bhadula, S.K.1    Shargool, P.D.2
  • 48
    • 0037237928 scopus 로고    scopus 로고
    • The phloem, a miracle of ingenuity
    • van Bel AJE (2003) The phloem, a miracle of ingenuity. Plant Cell Environ 25, 125 149.
    • (2003) Plant Cell Environ , vol.25 , pp. 125-149
    • Van Bel, A.J.E.1
  • 50
    • 0038460054 scopus 로고    scopus 로고
    • Light and carbon signalling pathways. Modeling circuits of interactions
    • Thum KE, Shasha DE, Lajay LV Coruzzi GM (2003) Light and carbon signalling pathways. Modeling circuits of interactions. Plant Physiol 132, 440 452.
    • (2003) Plant Physiol , vol.132 , pp. 440-452
    • Thum, K.E.1    Shasha, D.E.2    Lajay, L.V.3    Coruzzi, G.M.4
  • 51
    • 0000969376 scopus 로고
    • Differential effects of nitrate and light on the expression of glutamine synthetase and ferredoxin-dependent glutamate synthase in maize
    • Sakakibara H, Kawabata S, Hase T Sugiyama T (1992) Differential effects of nitrate and light on the expression of glutamine synthetase and ferredoxin-dependent glutamate synthase in maize. Plant Cell Physiol 33, 1193 1198.
    • (1992) Plant Cell Physiol , vol.33 , pp. 1193-1198
    • Sakakibara, H.1    Kawabata, S.2    Hase, T.3    Sugiyama, T.4
  • 52
    • 0030063362 scopus 로고    scopus 로고
    • Metabolic regulation of asparagine synthetase gene expression in maize (Zea mays L.) root tips
    • Chevalier C, Bourgeois E, Just D Raymond P (1996) Metabolic regulation of asparagine synthetase gene expression in maize (Zea mays L.) root tips. Plant J 9, 1 11.
    • (1996) Plant J , vol.9 , pp. 1-11
    • Chevalier, C.1    Bourgeois, E.2    Just, D.3    Raymond, P.4
  • 53
    • 49749221698 scopus 로고
    • A modified ninhydrin colorimetric analysis for amino acids
    • Rosen H (1957) A modified ninhydrin colorimetric analysis for amino acids. Arch Biochem Biophys 67, 10 15.
    • (1957) Arch Biochem Biophys , vol.67 , pp. 10-15
    • Rosen, H.1
  • 54
    • 27644556042 scopus 로고    scopus 로고
    • Expression of a ferredoxin-dependent glutamate synthase gene in mesophyll and vascular cells and functions of the enzyme in ammonium assimilation in Nicotiana tabacum (L.)
    • Feraud M, Masclaux-Daubresse C, Ferrario-Méry S, Pageau K, Lelandais M, Ziegler C, Leboeuf E, Jouglet T, Viret L, Spampinato A et al. (2005) Expression of a ferredoxin-dependent glutamate synthase gene in mesophyll and vascular cells and functions of the enzyme in ammonium assimilation in Nicotiana tabacum (L.). Planta 222, 667 677.
    • (2005) Planta , vol.222 , pp. 667-677
    • Feraud, M.1    Masclaux-Daubresse, C.2    Ferrario-Méry, S.3    Pageau, K.4    Lelandais, M.5    Ziegler, C.6    Leboeuf, E.7    Jouglet, T.8    Viret, L.9    Spampinato, A.10


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