Genetic polymorphism of GST, NAT2, and MTRR and susceptibility to childhood acute leukemia

Molecular Biology

Volumn 42, Issue 2, 2008, Pages 187-197

  Gra, O A ^a,b   Glotov, A S ^c   Kozhekbayeva, Zh M ^b   Makarova, O V ^d   Nasedkina, T V ^a  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^b VAVILOV INSTITUTE OF GENERAL GENETICS   (Russian Federation)

^c D O OTT RESEARCH INSTITUTE OF OBSTETRICS   (Russian Federation)

^d N N BLOKHIN NATIONAL MEDICAL RESEARCH CENTER OF ONCOLOGY   (Russian Federation)

Author keywords

Biotransformation system; Childhood leukemia; Genetic polymorphism; Oligonucleotide microchips; Predictive diagnosis

Indexed keywords

EID: 44349172308     PISSN: 00268933     EISSN: 16083245     Source Type: Journal    
DOI: 10.1134/S0026893308020039     Document Type: Article

References (32)

1. Baranov V.S., Baranova E.V., Ivashchenko T.E., Aseev M.V. 2000. Genom cheloveka i geny "predraspolozhennosti." Vvedenie v prediktivnuyu meditsinu (The Human Genome and "Susceptibility Genes": Introduction to Predictive Medicine). St. Petersburg: Intermedika.
2. Kukes V.G. 2004. Metabolizm lekarsvennykh sredstv: kliniko- farmakologicheskie aspekty (Drug Metabiolism: Clinical-Pharmaceutical Aspects). Moscow: Reafarm.
3. Krajinovic M., Labuda D., Richer C., et al. 1999. Susceptibility to childhood acute lymphoblastic leukemia: Influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 genetic polymorphisms. Blood. 93, 1496-1501.
4. Lemos M.C., Cabrita F.J., Silva H.A., et al. 1999. Genetic polymorphism of CYP2D6, GSTM1, and NAT2 and susceptibility to hematological neoplasias. Carcinogenesis. 20, 1225-1229.
5. Maiorova O.A., Mogl I.O., Henza G., et al. 2002. Polymorphism of CYP2D6 and NQO1 in children with acute myoblastic leukemia. Vopr. Gematol. Onkol. Immunopatol. Pediatr. 1, 52-59.
6. Balta G., Yuksek N., Ozyurek E., et al. 2003. Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia. Am. J. Hematol. 73, 154-160.
7. Joseph T., Kusumakumary P., Chacko P., et al. 2004. Genetic polymorphism of CYP1A1, CYP2D6, GSTM1, and GSTT1 and susceptibility to acute lymphoblastic leukemia in Indian children. Pediatr. Blood Cancer. 43, 560-567.
8. Aydin-Sayitoglu M., Hatirnaz O., Erensoy N., Ozbek U. 2006. Role of CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 genes in the susceptibility to acute leukemias. Am. J. Hematol. 81, 162-170.
9. Kuznetsova O.A., Yakupova E.V., Teppone S.L., et al. 2006. Polymorphism of glutathione S-transferase genes GSTM1, GSTT1 and GSTP1 in children with acute lymphoblastic leukemia. Med. Genet. 5, 37-42.
10. Krajinovic M., Richer C., Sinnett H., et al. 2000. Genetic polymorphisms of N-acetyltransferases 1 and 2 and genegene interaction in the susceptibility to childhood acute lymphoblastic leukemia. Cancer Epidemiol. Biomarkers Prev. 9, 557-562.
11. Krajinovic M., Sinnett H., Richer C., et al. 2002. Role of NQO1, MPO, and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Int. J. Cancer. 97, 230-236.
12. Gemmati D., Ongaro A., Scapoli G.L., et al. 2004. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Cancer Epidemiol. Biomarkers Prev. 13, 787-794.
13. Gast A., Bermejo J.L., Flohr T., et al. 2007. Folate metabolic gene polymorphisms and childhood acute lymphoblastic leukemia: A case-control study. Leukemia. 21, 320-325.
14. Harris N.L., Jaffe E.S., Diebold J., et al. 1999. The World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. Report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November, 1997. Ann. Oncol. 10, 1419-1432.
15. Glotov A.S., Nasedkina T.V., Ivashchenko T.E., et al. 2005. Development of a biochip for analyzing polymorphism of the biotransformation genes. Mol. Biol. 39, 403-412.
16. Fotin A., Drobyshev A., Proudnikov D., Perov A., Mirzabekov A. 1998. Parallel thermodynamic analysis of duplexes on oligodeoxyribonucleotide microchips. Nucleic Acids Res. 26, 1515-1521.
17. Webb G., Vaska V., Coggan M., Board P. 1996. Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1). Genomics. 33, 121-123.
18. Pearson W.R., Vorachek W.R., Xu S.J., et al. 1993. Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13. Am. J. Hum. Genet. 53, 220-233.
19. Sinnett D., Krajinovic M., Labuda D. 2000. Genetic susceptibility to childhood acute lymphoblastic leukemia. Leuk. Lymphoma. 38, 447-462.
20. Blum M., Grant D.M., McBride W., et al. 1990. Human arylamine N-acetyltransferase genes: Isolation, chromosomal localization, and functional expression. DNA Cell Biol. 9, 193-203.
21. http://www.louisville.edu/medschool/pharmacology/NAT2.html
22. Kozhekbaeva Zh.M., Glotov A.S., Gra O.A., et al. 2007. Analysis of NAT2 point mutations with biological microchips. Mol. Biol. 41, 725-733.
23. Pompeo F., Brooke E., Kawamura A., Mushtaq A., Sim E. 2002. The pharmacogenetics of NAT: Structural aspects. Pharmacogenomics. 3, 19-30.
24. Hein D.W. 2002. Molecular genetics and function of NAT1 and NAT2: Role in aromatic amine metabolism and carcinogenesis. Mutat. Res. 506-507, 65-77.
25. Cascorbi I., Brockmoller J., Mrozikiewicz P.M., et al. 1996. Homozygous rapid arylamine N-acetyltransferase (NAT2) genotype as a susceptibility factor for lung cancer. Cancer Res. 56, 3961-3966.
26. Gil J.P., Lechner M.C. 1998. Increased frequency of wild-type arylamine-N-acetyltransferase allele NAT2*4 homozygotes in Portuguese patients with colorectal cancer. Carcinogenesis. 19, 37-41.
27. Leclerc D., Wilson A., Dumas R., et al. 1998. Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria. Proc. Natl. Acad. Sci. USA. 95, 3059-3064.
28. Wilson A., Platt R., Wu Q., et al. 1999. A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Mol. Genet. Metab. 67, 317-323.
29. Banerjee R. 1997. The Yin-Yang of cobalamin biochemistry. Chem. Biol. 4, 175-186.
30. Nakamura M., Sugita K., Inukai T., et al. 1999. p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation. Leukemia. 13, 884-890.
31. Guo S.X., Taki T., Ohnishi H., et al. 2000. Hypermethylation of p16 and p15 genes and RB protein expression in acute leukemia. Leuk. Res. 24, 39-46.
32. Bender C.M., Pao M.M., Jones P.A. 1998. Inhibition of DNA methylation by 5-aza-2′-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res. 58, 95-101.