메뉴 건너뛰기




Volumn 178, Issue 2-3, 2008, Pages 192-198

Off-line HPLC method combined to LC-MS for the determination of sildenafil and its active metabolite in post-mortem human blood according to confirmation criteria

Author keywords

Confirmation criteria; HPLC UV vis; N Desmethylsildenafil; Sildenafil

Indexed keywords

ACETONITRILE; DISODIUM HYDROGEN PHOSPHATE; DRUG METABOLITE; N DESMETHYLSILDENAFIL; SILDENAFIL; SILICON DIOXIDE; TRIETHYLAMINE;

EID: 44349155278     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.forsciint.2008.03.018     Document Type: Article
Times cited : (29)

References (18)
  • 2
    • 0032502708 scopus 로고    scopus 로고
    • Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells
    • Moreland R.B., Goldstein I., and Traish A. Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells. Life Sci. 62 (1998) PL309-PL318
    • (1998) Life Sci. , vol.62
    • Moreland, R.B.1    Goldstein, I.2    Traish, A.3
  • 4
    • 0031920611 scopus 로고    scopus 로고
    • The effect of the specific phosphodiesterase (PDE) inhibitors on human and rabbit cavernous tissue in vitro and in vivo
    • Stief C.G., Uckert S., Becker A.J., Truss M.C., and Jonas U. The effect of the specific phosphodiesterase (PDE) inhibitors on human and rabbit cavernous tissue in vitro and in vivo. J. Urol. 159 (1998) 1390-1393
    • (1998) J. Urol. , vol.159 , pp. 1390-1393
    • Stief, C.G.1    Uckert, S.2    Becker, A.J.3    Truss, M.C.4    Jonas, U.5
  • 5
    • 85168040905 scopus 로고    scopus 로고
    • Viagra/Clinical Pharmacology/Pharmacokinetics and Metabolism, http://www.rxlist.com/cgi/generic/viagra.htm, May 2007.
    • Viagra/Clinical Pharmacology/Pharmacokinetics and Metabolism, http://www.rxlist.com/cgi/generic/viagra.htm, May 2007.
  • 6
    • 0035135859 scopus 로고    scopus 로고
    • Determination of sildenafil citrate in plasma by high-performance liquid chromatography and a case for the potential interaction of grapefruit juice with sildenafil citrate
    • Lee M., and Min D. Determination of sildenafil citrate in plasma by high-performance liquid chromatography and a case for the potential interaction of grapefruit juice with sildenafil citrate. Ther. Drug Monit. 23 1 (2001) 21-26
    • (2001) Ther. Drug Monit. , vol.23 , Issue.1 , pp. 21-26
    • Lee, M.1    Min, D.2
  • 7
    • 0038697808 scopus 로고    scopus 로고
    • Development of a liquid chromatographic method for bioanalytical applications with sildenafil
    • Thau Sheu M., Wu A.B., Cheng Y.G., Hsia A., and Ho H. Development of a liquid chromatographic method for bioanalytical applications with sildenafil. J. Chromatogr. B 791 (2003) 255-262
    • (2003) J. Chromatogr. B , vol.791 , pp. 255-262
    • Thau Sheu, M.1    Wu, A.B.2    Cheng, Y.G.3    Hsia, A.4    Ho, H.5
  • 8
    • 28444478010 scopus 로고    scopus 로고
    • Liquid chromatographic-tandem mass spectrometric method for the quantitation of sildenafil in human plasma
    • Wang Y., Wang J., Cui Y., Fawcett J.P., and Gu J. Liquid chromatographic-tandem mass spectrometric method for the quantitation of sildenafil in human plasma. J. Chromatogr. B 828 (2005) 118-121
    • (2005) J. Chromatogr. B , vol.828 , pp. 118-121
    • Wang, Y.1    Wang, J.2    Cui, Y.3    Fawcett, J.P.4    Gu, J.5
  • 9
    • 0037333781 scopus 로고    scopus 로고
    • HPLC-MS for the determination of sildenafil citrate (Viagra) in biological fluids. Application to the salivary excretion of sildenafil after oral intake
    • Tracqui A., and Ludes B. HPLC-MS for the determination of sildenafil citrate (Viagra) in biological fluids. Application to the salivary excretion of sildenafil after oral intake. J. Anal. Toxicol. 27 (2003) 88-94
    • (2003) J. Anal. Toxicol. , vol.27 , pp. 88-94
    • Tracqui, A.1    Ludes, B.2
  • 10
    • 33646189207 scopus 로고    scopus 로고
    • Quantitative determination of sildenafil (Viagra) and its metabolite (UK-103,320) in fluid and tissue specimens obtained from six aviation fatalities
    • Lewis J.R., Johnson R.D., and Blank L.C. Quantitative determination of sildenafil (Viagra) and its metabolite (UK-103,320) in fluid and tissue specimens obtained from six aviation fatalities. J. Anal. Tox. 30 (2006) 14-20
    • (2006) J. Anal. Tox. , vol.30 , pp. 14-20
    • Lewis, J.R.1    Johnson, R.D.2    Blank, L.C.3
  • 11
    • 0035055805 scopus 로고    scopus 로고
    • Post-mortem detection and identification of sildenafil (Viagra) and its metabolites by LC/MS and LC/MS/MS
    • Weinmann W., Bohnert M., Wiedemann A., Renz M., Lehmann N., and Pollak S. Post-mortem detection and identification of sildenafil (Viagra) and its metabolites by LC/MS and LC/MS/MS. Int. J. Legal Med. 114 (2001) 252-258
    • (2001) Int. J. Legal Med. , vol.114 , pp. 252-258
    • Weinmann, W.1    Bohnert, M.2    Wiedemann, A.3    Renz, M.4    Lehmann, N.5    Pollak, S.6
  • 12
    • 33845609316 scopus 로고    scopus 로고
    • Simultaneous determination of sildenafil and N-desmethyl sildenafil in human plasma by high-performance liquid chromatography method using electrochemical detection with application to a pharmacokinetic study
    • Al-Ghazawi M., Tutunji M., and Aburuz S. Simultaneous determination of sildenafil and N-desmethyl sildenafil in human plasma by high-performance liquid chromatography method using electrochemical detection with application to a pharmacokinetic study. J. Pharm. Biomed. Anal. 43 (2007) 613-618
    • (2007) J. Pharm. Biomed. Anal. , vol.43 , pp. 613-618
    • Al-Ghazawi, M.1    Tutunji, M.2    Aburuz, S.3
  • 13
    • 0030780668 scopus 로고    scopus 로고
    • Development of an assay for the simultaneous determination of sildenafil (Viagra) and its metabolite (UK-103,320) using automated sequential trace enrichment of dialysates and high-performance liquid chromatography
    • Cooper J.D., Muirhead D.C., Taylor J.E., and Baker P.R. Development of an assay for the simultaneous determination of sildenafil (Viagra) and its metabolite (UK-103,320) using automated sequential trace enrichment of dialysates and high-performance liquid chromatography. J. Chromatogr. B 701 (1997) 87-95
    • (1997) J. Chromatogr. B , vol.701 , pp. 87-95
    • Cooper, J.D.1    Muirhead, D.C.2    Taylor, J.E.3    Baker, P.R.4
  • 14
    • 0035207146 scopus 로고    scopus 로고
    • Hair analysis for pharmaceutical drugs. II. Effective extraction and determination of sildenafil (Viagra) and its N-desmethyl metabolite in rat and human hair by GC-MS
    • Saisho K., Scott K.S., Morimoto S., and Nakahara Y. Hair analysis for pharmaceutical drugs. II. Effective extraction and determination of sildenafil (Viagra) and its N-desmethyl metabolite in rat and human hair by GC-MS. Biol. Pharm. Bull. 24 12 (2001) 1384-1388
    • (2001) Biol. Pharm. Bull. , vol.24 , Issue.12 , pp. 1384-1388
    • Saisho, K.1    Scott, K.S.2    Morimoto, S.3    Nakahara, Y.4
  • 16
    • 85168041442 scopus 로고    scopus 로고
    • P. Van Hee, H. Neels, W. Lambert, V. Coucke, M. Dedoncker, Comment on: J. Anal. Toxicol. 29 (2005) 254-257: Postmortem distribution of sildenafil in histological material, J. Anal. Toxicol. 30 (2006) 403-404; author reply 404-405.
    • P. Van Hee, H. Neels, W. Lambert, V. Coucke, M. Dedoncker, Comment on: J. Anal. Toxicol. 29 (2005) 254-257: Postmortem distribution of sildenafil in histological material, J. Anal. Toxicol. 30 (2006) 403-404; author reply 404-405.
  • 17
    • 85168048445 scopus 로고    scopus 로고
    • Official Journal of the European Communities L221, 8-36. Commission decision (2002/657/EC) of 12 August 2002 concerning the performance of analytical methods and the interpretation of results. Brussels, Belgium, 2002.
    • Official Journal of the European Communities L221, 8-36. Commission decision (2002/657/EC) of 12 August 2002 concerning the performance of analytical methods and the interpretation of results. Brussels, Belgium, 2002.
  • 18
    • 0038697808 scopus 로고    scopus 로고
    • Development of a liquid chromatographic method for bioanalytical applications with sildenafil
    • Sheu M.T., Wu A.B., Yeh G.C., Hsia A., and Ho H. Development of a liquid chromatographic method for bioanalytical applications with sildenafil. J. Chromatogr. B 791 (2003) 255-262
    • (2003) J. Chromatogr. B , vol.791 , pp. 255-262
    • Sheu, M.T.1    Wu, A.B.2    Yeh, G.C.3    Hsia, A.4    Ho, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.