Direct evidence for deprotonation of a lysine side chain buried in the hydrophobic core of a protein

Journal of the American Chemical Society

Volumn 130, Issue 21, 2008, Pages 6714-6715

  Takayama, Yuki ^a   Castañeda, Carlos A ^b   Chimenti, Michael ^b   García Moreno, Bertrand ^b   Iwahara, Junji ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYSINE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; HYDROPHOBICITY; NITROGEN NUCLEAR MAGNETIC RESONANCE; PH MEASUREMENT; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS;

HYDROPHOBICITY; KINETICS; LYSINE; MICROCOCCAL NUCLEASE; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTONS;

EID: 44349125669     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja801731g     Document Type: Article

References (17)

1. Garcia-Moreno, B.; Dwyer, J. J.; Gittis, A. G.; Lattman, E. E.; Spencer, D. S.; Stites, W. E. Biophys. Chem. 1997, 64, 211-224.
2. Stites, W. E.; Gittis, A. G.; Lattman, E. E.; Shortle, D. J. Mol. Biol. 1991, 221, 7-14.
3. Fitch, C. A.; Karp, D. A.; Lee, K. K.; Stites, W. E.; Lattman, E. E.; Garcia-Moreno, B. Biophys. J. 2002, 82, 3289-3304.
4. Abragam, A. The Principle of Nuclear Magnetism; Clarendon Press: Oxford, 1961.
5. Iwahara, J.; Jung, Y. S.; Clore, G. M. J. Am. Chem. Soc. 2007, 129, 2971-2980.
6. Andre, I.; Linse, S.; Mulder, F. A. J. Am. Chem. Soc. 2007, 129, 15805-15813.
7. Poon, D. K.; Schubert, M.; Au, J.; Okon, M.; Withers, S. G.; McIntosh, L. P. J. Am. Chem. Soc. 2006, 128, 15388-15389.
8. Sohár, P. Nuclear Magnetic Resonance Spectroscopy; CRC Press: Boca Raton, FL, 1984; Vol. 1.
9. Kölmel, C.; Ochsenfeld, C.; Ahlrichs, R. Theor. Chim. Acta 1992, 82, 271-284.
10. Hwang, T. L.; van Zijl, P. C.; Mori, S. J. Biomol. NMR 1998, 11, 221-226.
11. Englander, S. W.; Downer, N. W.; Teitelbaum, H. Annu. Rev. Biochem. 1972, 41, 903-924.
12. Liepinsh, E.; Otting, G. Magn. Reson. Med. 1996, 35, 30-42.
13. Cavanagh, J.; Fairbrother, W. J.; Palmer, A. G., III.; Skelton, N. J,. Protein NMR Spectroscopy: Principles and Practice; Academic Press: San Diego, CA, 1996.
14. Harbison, G. S. J. Am. Chem. Soc. 1993, 115, 3026-3027.
15. Hu, K. F.; Vogeli, B.; Clore, G. M. Chem. Phys. Lett. 2006, 423, 123-125.
16. Damjanovic, A.; Garcia-Moreno, B.; Lattman, E. E.; Garcia, A. E. Proteins 2005, 60, 433-449.
17. Segawa, T.; Kateb, F.; Duma, L.; Bodenhausen, G.; Pelupessy, P. Chembiochem 2008, 9, 537-542.