Expression and subcellular localization of thymosin beta15 following kainic acid treatment in rat brain

Biochemical and Biophysical Research Communications

Volumn 371, Issue 4, 2008, Pages 664-669

  Kim, Young Woong ^a   Kim, Younghwa ^a   Kim, Eun Hae ^a   Koh, Doyle ^a   Sun, Woong ^a   Kim, Hyun ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

Kainic acid; Nuclear translocation; Staurosporine induced apoptosis; Thymosin 15

Indexed keywords

G ACTIN; KAINIC ACID; MESSENGER RNA; NUCLEIC ACID; STAUROSPORINE; THYMOSIN BETA15; THYMUS HORMONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; BRAIN REGION; CELL CULTURE; CELL STIMULATION; CELL VIABILITY; CYTOSOL; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MALE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RAT; SITE DIRECTED MUTAGENESIS;

ACTINS; ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID MOTIFS; ANIMALS; APOPTOSIS; CELL NUCLEUS; CEREBRAL CORTEX; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; KAINIC ACID; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; THYMOSIN;

RATTUS;

EID: 44349122293     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.04.112     Document Type: Article

References (27)

1. Goldstein A.L., Hannappel E., and Kleinman H.K. Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues. Trends Mol. Med. 11 (2005) 421-429
2. Sun W., and Kim H. Neurotrophic roles of the beta-thymosins in the development and regeneration of the nervous system. Ann. N. Y. Acad. Sci. 1112 (2007) 210-218
3. Choe J., Sun W., Yoon S.Y., Rhyu I.J., Kim E.H., and Kim H. Effect of thymosin beta15 on the branching of developing neurons. Biochem. Biophys. Res. Commun. 331 (2005) 43-49
4. Bao L., Loda M., Janmey P.A., Stewart R., Anand-Apte B., and Zetter B.R. Thymosin beta 15: a novel regulator of tumor cell motility upregulated in metastatic prostate cancer. Nat. Med. 2 (1996) 1322-1328
5. Roth L.W., Bormann P., Bonnet A., and Reinhard E. Beta-thymosin is required for axonal tract formation in developing zebrafish brain. Development 126 (1999) 1365-1374
6. van Kesteren R.E., Carter C., Dissel H.M., van Minnen J., Gouwenberg Y., Syed N.I., Spencer G.E., and Smit A.B. Local synthesis of actin-binding protein beta-thymosin regulates neurite outgrowth. J. Neurosci. 26 (2006) 152-157
7. Choi S.Y., Kim D.K., Eun B., Kim K., Sun W., and Kim H. Anti-apoptotic function of thymosin-beta in developing chick spinal motoneurons. Biochem. Biophys. Res. Commun. 346 (2006) 872-878
8. Choi S.Y., Noh M.R., Kim D.K., Sun W., and Kim H. Neuroprotective function of thymosin-beta and its derivative peptides on the programmed cell death of chick and rat neurons. Biochem. Biophys. Res. Commun. 362 (2007) 587-593
9. Kim Y., Kim E.H., Hong S., Rhyu I.J., Choe J., Sun W., and Kim H. Expression of thymosin beta in the rat brain following transient global ischemia. Brain Res. 1085 (2006) 177-182
10. Vartiainen N., Pyykonen I., Hokfelt T., and Koistinaho J. Induction of thymosin beta(4) mRNA following focal brain ischemia. Neuroreport 7 (1996) 1613-1616
11. Carpintero P., Anadon R., Diaz-Regueira S., and Gomez-Marquez J. Expression of thymosin beta4 messenger RNA in normal and kainate-treated rat forebrain. Neuroscience 90 (1999) 1433-1444
12. Carpintero P., Anadon R., and Gomez-Marquez J. Expression of the thymosin beta10 gene in normal and kainic acid-treated rat forebrain. Brain Res. Mol. Brain Res. 70 (1999) 141-146
13. Sun W., Kang Y., Kim I.H., Kim E.H., Rhyu I.J., Kim H.J., and Kim H. Inhibition of rat brain inositol 1,4,5-trisphosphate 3-kinase A expression by kainic acid. Neurosci. Lett. 392 (2006) 181-186
14. Kudo N., Wolff B., Sekimoto T., Schreiner E.P., Yoneda Y., Yanagida M., Horinouchi S., and Yoshida M. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell Res. 242 (1998) 540-547
15. Wada A., Fukuda M., Mishima M., and Nishida E. Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein. EMBO J. 17 (1998) 1635-1641
16. Magloczky Z., and Freund T.F. Selective neuronal death in the contralateral hippocampus following unilateral kainate injections into the CA3 subfield. Neuroscience 56 (1993) 317-335
17. Nadler J.V., Perry B.W., Gentry C., and Cotman C.W. Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid. J. Comp. Neurol. 192 (1980) 333-359
18. Nadler J.V., Perry B.W., Gentry C., and Cotman C.W. Fate of the hippocampal mossy fiber projection after destruction of its postsynaptic targets with intraventricular kainic acid. J. Comp. Neurol. 196 (1981) 549-569
19. Grant D.S., Rose W., Yaen C., Goldstein A., Martinez J., and Kleinman H. Thymosin beta4 enhances endothelial cell differentiation and angiogenesis. Angiogenesis 3 (1999) 125-135
20. Huff T., Rosorius O., Otto A.M., Muller C.S., Ballweber E., Hannappel E., and Mannherz H.G. Nuclear localisation of the G-actin sequestering peptide thymosin beta4. J. Cell. Sci. 117 (2004) 5333-5341
21. Zoubek R.E., and Hannappel E. Subcellular distribution of thymosin beta4. Ann. N. Y. Acad. Sci. 1112 (2007) 442-450
22. Clark T.G., and Merriam R.W. Diffusible and bound actin nuclei of Xenopus laevis oocytes. Cell 12 (1977) 883-891
23. Nakayasu H., and Ueda K. Association of actin with the nuclear matrix from bovine lymphocytes. Exp. Cell Res. 143 (1983) 55-62
24. Rando O.J., Zhao K., and Crabtree G.R. Searching for a function for nuclear actin. Trends Cell Biol. 10 (2000) 92-97
25. Gourlay C.W., and Ayscough K.R. The actin cytoskeleton: a key regulator of apoptosis and ageing?. Nat. Rev. Mol. Cell Biol. 6 (2005) 583-589
26. Schwob J.E., Fuller T., Price J.L., and Olney J.W. Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: a histological study. Neuroscience 5 (1980) 991-1014
27. Brieger A., Plotz G., Zeuzem S., and Trojan J. Thymosin beta 4 expression and nuclear transport are regulated by hMLH1. Biochem. Biophys. Res. Commun. 364 (2007) 731-736