Low-dose oral methotrexate induces apoptosis of tissue eosinophils in bullous pemphigoid

Acta Dermato-Venereologica

Volumn 88, Issue 3, 2008, Pages 219-222

  Dahlman Ghozlan, Kristina ^a,b   Ortonne, Jean Paul ^b   Bahadoran, Philippe ^b   Spadafora, Anne ^b   Stephansson, Eija ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

Author keywords

Apoptosis; Bullous pemphigoid; Methotrexate; Skin eosinophils

Indexed keywords

BIOTIN; DNA NUCLEOTIDYLEXOTRANSFERASE; METHOTREXATE;

APOPTOSIS; ARTICLE; BULLOUS PEMPHIGOID; CELL COUNT; CELL LOSS; CLINICAL ARTICLE; CONTROLLED STUDY; EOSINOPHIL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; MICROSCOPY; NICK END LABELING; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ADMINISTRATION, ORAL; APOPTOSIS; BIOPSY; EOSINOPHILS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; IN SITU NICK-END LABELING; METHOTREXATE; MICROSCOPY; PEMPHIGOID, BULLOUS; SKIN;

EID: 44349111337     PISSN: 00015555     EISSN: None     Source Type: Journal    
DOI: 10.2340/00015555-0423     Document Type: Article

References (15)

1. Elder D, editor. Lever's histopathology of the skin, 8th edn. Philadelphia: Lippincott-Raven Publ., 1997: p. 226-234.
2. Dahlman-Ghozlan K, Heilborn JD, Stephansson E. Circulation levels of soluble E-selectin, ICAM-1 and VCAM-1 in bullous pemphigoid during low-dose methotrexate therapy. A prospective study. Exp Dermatol 2000; 9: 336-340.
3. Dahlman-Ghozlan K, Ortonne J-P, Heilborn JD, Stephansson E. Altered tissue expression pattern of cell adhesion molecules, ICAM-1, E-selectin and VCAM-1, in bullous pemphigoid during methotrexate therapy. Exp Dermatol 2004; 13: 65-69.
4. Heilborn JD, Ståhle-Bäckdahl M, Albertioni F, Vassilaki I, Persson C, Stephansson E. Low-dose oral methotrexate as a mono-therapy in elderly patients with bullous pemphigoid. J Am Acad Dermatol 1999; 40: 741-749.
5. Kerr JF, Wyllie Ah, Currie AR. Cell death. The significance of apoptosis. Int Rev Cytol 1980; 68: 251-306.
6. Thompson C.B Apoptosis in the pathogenesis and treatment of disease. Science 1995; 267: 1456-1462.
7. Mountz JD, Wu J, Zhou T. Auto-immune disease. A problem of defective apoptosis. Arthritis Rheum 1994; 37: 1415-1420.
8. Bonkhoff H, Fixemer T, Hunsicker I, Remeberger K. Simultaneous detection of DNA fragmentation (apoptosis), cell proliferation (MIB-1) and phenotype markers in routinely processed tissue sections. Virchows Arch 1999; 434: 71-73.
9. Nakajima H, Loegering D, Kita H, Kephart G, Gleich G. Reactivity of monoclonal antibodies EG1 and EG 2 with eosinophils and their granule proteins. J Leucoc Biol, 1999; 66: 447-454.
10. Shikhande M, Hunziker T, Braathen R, Pichler WJ, Dahinden CA, Yawalkar N. Increased coexpression of eotaxin and interleukin 5 in bullous pemphigoid. Acta Derm Venereol 2000; 80: 277-280.
11. Rico M J, Benning C, Weingart ES, Streilein RD, Hall RP. Characterization of skin cytokines in bullous pemphigoid and pemphigus vulgaris. Br J Dermatol 1999, 40: 1079-1086.
12. Walsh GM. Human eosinophils: their accumulation, activation and fate. Br J Haematol 1997; 97: 701-709.
13. Ohta K, Yamashita N. Apoptosis of eosinophils and lymphocytes in allergic inflammation. J Allergy Clin Immunol 1999; 104: 14-21.
14. Simon H-U, Alam R. Regulation of eosinophil apoptosis transduction of survival and death signal. Int Arch Allergy Immunol 1999; 118: 7-14.
15. Walsh GM, Sexton DW, Baylock MG. Corticosteroids, eosinophils and bronchial epithelial cells: new insights into the resolution of inflammation in asthma. J Endocrinol 2003; 178: 37-43.