Determination of levonorgestrel in human plasma by liquid chromatography - Tandem mass spectrometry method: Application to a bioequivalence study of two formulations in healthy volunteers

Biomedical Chromatography

Volumn 22, Issue 5, 2008, Pages 519-526

  Zhao, Li Zi ^a   Zhong, Guo Ping ^a   Bi, Hui Chang ^a   Ding, Liang ^a   Deng, Ying ^a   Guan, Su ^a   Chen, Xiao ^a   Huang, Zhi Ying ^a   Huang, Min ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Bioavailability; Bioequivalence; Levonorgestrel; Liquid chromatography tandem mass spectrometry; Pharmacokinetics

Indexed keywords

BIOCHEMISTRY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA (HUMAN); QUALITY CONTROL;

BIOAVAILABILITY; BIOEQUIVALENCE; BIOEQUIVALENCE STUDY; HEALTHY VOLUNTEERS; HUMAN PLASMAS; LC-MS-MS; LEVONORGESTREL; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; RUNNING TIME;

PARTICLE SIZE;

ACETIC ACID ETHYL ESTER; HEXANE; LEVONORGESTREL;

ACCURACY; ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; BLOOD SAMPLING; CLINICAL TRIAL; COLUMN CHROMATOGRAPHY; CONCENTRATION PROCESS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DOSAGE FORM COMPARISON; DRUG ELIMINATION; DRUG SELECTIVITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MAXIMUM PLASMA CONCENTRATION; MENSTRUAL IRREGULARITY; NORMAL HUMAN; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY ANALYSIS; SINGLE DRUG DOSE; STRUCTURE ANALYSIS; TABLET FORMULATION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

EID: 44249122831     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.963     Document Type: Article

References (11)