The mtDNA A8344G "MERRF" mutation is not a common cause of sporadic Parkinson disease in Italian population

Parkinsonism and Related Disorders

Volumn 14, Issue 4, 2008, Pages 381-382

  Mancuso, Michelangelo ^a   Nesti, Claudia ^a   Petrozzi, Lucia ^a   Orsucci, Daniele ^a   Frosini, Daniela ^a   Kiferle, Lorenzo ^a   Bonuccelli, Ubaldo ^a   Ceravolo, Roberto ^a   Murri, Luigi ^a   Siciliano, Gabriele ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ADULT; AGED; CLINICAL FEATURE; COGNITIVE DEFECT; FEMALE; GENE; GENE DELETION; GENE EXPRESSION; GENE MUTATION; HUMAN; ITALY; LETTER; MALE; MERRF GENE; NERVE DEGENERATION; OXIDATIVE STRESS; PARKINSON DISEASE; PARKINSONISM; POLG1 GENE; PRIORITY JOURNAL; SUBSTANTIA NIGRA; SYMPTOMATOLOGY;

DNA, MITOCHONDRIAL; HUMANS; ITALY; MERRF SYNDROME; MUTATION; PARKINSON DISEASE;

EID: 44249121942     PISSN: 13538020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2007.10.001     Document Type: Letter

References (6)

1. Lean M.T., and Beal M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443 (2006) 787-795
2. Siciliano G., Mancuso M., Ceravolo R., Lombardi V., Iudice A., and Bonuccelli U. Mitochondrial DNA rearrangements in young onset parkinsonism: two case reports. J Neurol Neurosurg Psychiatry 71 (2001) 685-687
3. Davidzon G., Greene P., Mancuso M., Klos K.J., Ahlskog J.E., Hirano M., et al. Early-onset familial parkinsonism due to POLG mutations. Ann Neurol 59 (2006) 859-862
4. Luoma P., Melberg A., Rinne J.O., Kaukonen J.A., Nuppponen N.N., Chalmers R.M., et al. Parkinsonism, premature menopause, and mitochondrial DNA polymerase mutations: clinical and molecular genetic study. Lancet 364 (2004) 875-882
5. Gu M., Cooper J.M., Taanman J.W., and Schapira Ah. Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease. Ann Neurol 44 (1998) 177-186
6. Lys. Neurology 68 (2007) 56-58