Inhibitor of sarco-endoplasmic reticulum Ca2+-ATPase thapsigargin stimulates production of nitric oxide and secretion of interferon-gamma

European Journal of Pharmacology

Volumn 588, Issue 1, 2008, Pages 85-92

  Kmoníčková, Eva ^a   Melkusová, Petra ^a   Harmatha, Juraj ^b   Vokáč, Karel ^b   Farghali, Hassan ^c   Zídek, Zdeněk ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Human peripheral blood mononuclear cell; Interferon ; Macrophage; Nitric oxide; Thapsigargin

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; NITRILE; THAPSIGARGIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BIOSYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG POTENCY; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RAT; SUPERNATANT;

ANIMALS; ARGINASE; CALCIUM-TRANSPORTING ATPASES; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; FEMALE; HISTAMINE; HUMANS; INDICATORS AND REAGENTS; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; NF-KAPPA B; NITRIC OXIDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, INBRED LEW; STERILIZATION; THAPSIGARGIN;

EID: 44249116363     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.03.037     Document Type: Article

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