Multidrug Resistance-1 in T Lymphocytes and Natural Killer Cells of Adults with Idiopathic Thrombocytopenic Purpura: Effect of Prednisone Treatment

Archives of Medical Research

Volumn 39, Issue 5, 2008, Pages 541-545

  López Karpovitch, Xavier ^a   Graue, Gerardo ^a   Crespo Solís, Erick ^a   Piedras, Josefa ^a  

^a INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

Author keywords

Idiopathic thrombocytopenic purpura; MRK16 antigen; Multidrug resistance 1; NK cells; P glycoprotein; T lymphocytes

Indexed keywords

GLUCOCORTICOID; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; PREDNISONE;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MALE; NATURAL KILLER CELL; PROTEIN FUNCTION; T LYMPHOCYTE; TREATMENT OUTCOME;

ADULT; DRUG RESISTANCE, MULTIPLE; FEMALE; HUMANS; KILLER CELLS, NATURAL; MALE; MIDDLE AGED; P-GLYCOPROTEIN; PREDNISONE; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; T-LYMPHOCYTES;

EID: 44249116157     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2008.04.004     Document Type: Article

References (24)

1. Coopamah M.D., Garvey M.B., Freedman J., and Semple J.W. Cellular immune mechanisms in autoimmune thrombocytopenic purpura: an update. Transfus Med Rev 17 (2003) 69-80
2. Semple J.W., Milev Y., Cosgrave D., Mody M., Horstein A., and Freedman J. Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity. Blood 87 (1996) 4245-4254
3. Wang T., Zhao H., Ren H., Guo J., Xu M., Yang R., et al. Type 1 and type 2 T-cell profiles in idiopathic thrombocytopenic purpura. Haematologica 90 (2005) 914-923
4. Liu F., Wu C., Yang X., Xiao H., Zhuo X., Cheng Z., et al. Polarization and apoptosis of T cell subsets in idiopathic thrombocytopenic purpura. Cell Mol Immunol 2 (2005) 387-392
5. Shinomura T., Fujimura K., Takafuta T., Fuji T., Katsutani S., Noda M., et al. Oligoclonal accumulation of T cells in peripheral blood from patients with idiopathic thrombocytopenic purpura. Br J Haematol 95 (1996) 732-737
6. Stasi R., Del Poeta G., Stipa E., Evangelista M.L., Trawinska M.M., Cooper N., et al. Response to B-cell-depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura. Blood 110 (2007) 2924-2930
7. Cines D.B., and Blanchette V.S. Immune thrombocytopenic purpura. N Engl J Med 346 (2002) 995-1008
8. Gottesman M.M., and Pastan I. Biochemestry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62 (1993) 385-427
9. Farrell R.J., and Kelleher D. Mechanism of steroid action and resistance in inflammation. J Endocrinol 178 (2003) 339-346
10. Ludescher C., Pall G., Irschick E.U., and Gastl G. Differential activity of P-glycoprotein in normal blood lymphocyte subsets. Br J Haematol 101 (1998) 722-727
11. Díaz-Borjon A., Richaud-Patin Y., Alvarado de la Barrera C., Jakez-Ocampo J., Ruíz-Argüelles A., Llorente L., et al. Multidrug resistance-1 (MDR-1) in rheumatic autoimmune disorders II. Increased P-glycoprotein activity in lymphocytes from systemic lupus erythematosus patients might affect steroid requirements for disease control. Joint Bone Spine 67 (2000) 40-48
12. Llorente L., Richaud-Patin Y., Diaz-Borjon A., Alvarado de la Barrera C., Jakez-Ocampo J., de la Fuente H., et al. Multidrug resistance-1 (MDR-1) in rheumatic autoimmune disorders I. Increased P-glycoprotein activity in lymphocytes from rheumatoid arthritis patients might influence disease outcome. Joint Bone Spine 67 (2000) 30-39
13. Maillefert J.F., Maynadie M., Tebib J.G., Aho S., Walter P., Chatard C., et al. Expression of the multidrug resistance glycoprotein 170 in the peripheral blood lymphocytes of rheumatoid arthritis patients. The percentage of lymphocytes expressing glycoprotein 170 is increased in patients treated with prednisone. Br J Rheumatol 35 (1996) 430-435
14. Richaud-Patin Y., Vega-Boada F., Vidaller A., and Llorente L. Multidrug resistance-1 (MDR-1) in autoimmune disorders IV. P-glycoprotein overfunction in lymphocytes from myasthenia gravis patients. Biomed Pharmacother 58 (2004) 320-324
15. Levy A.S., Cunningham-Rundles S., Mazza B., Simm M., Gorlick R., and Bussel J. High P-glycoprotein-mediated export observed in patients with a history of idiopathic thrombocytopenic purpura. Br J Haematol 118 (2002) 836-838
16. Ruiz-Soto R., Richaud-Patin Y., López-Karpovitch X., and Llorente L. Multidrug resistance-1 (MDR-1) in autoimmune disorders. III: Increased P-glycoprotein activity in lymphocytes from immune thrombocytopenic purpura patients. Exp Hematol 31 (2003) 483-487
17. Huet S., Marie J.-P., Gualde N., and Robert J. Reference method for detection of Pgp mediated multidrug resistance in human hematological malignancies: a method validated by the laboratories of the French drug resistance network. Cytometry B Clin Cytom 34 (1998) 248-256
18. Tafuri A., Gregorj C., Petrucci M.T., Ricciardi M.R., Mancini M., Cimino M., et al. MDR1 protein expression is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia. Blood 100 (2002) 974-981
19. George J.N., Woolf S.H., Raskob G.E., Wasser J.S., Aledort L.M., Ballem P.J., et al. Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood 88 (1996) 3-40
20. DiFino S.M., Lachant N.A., Kirshner J.J., and Gottlieb A.J. Adult idiopathic thrombocytopenic purpura: clinical findings and response to therapy. Am J Med 69 (1980) 430-442
21. + T cells: a role in cytotoxic effector function. J Clin Immunol 12 (1992) 451-458
22. Krishan A., and Arya P. Monitoring of cellular resistance to cancer chemotherapy. Hematol Oncol Clin North Am 16 (2002) 357-372
23. Germann U.A., Chambers T.C., Ambudkar S.V., Pastan I., and Gottesman M.M. Effect of phosphorylation of P-glycoprotein on multidrug resistance. J Bioenerg Biomembr 27 (1995) 53-61
24. Goodfellow H.R., Sardini A., Ruetz S., Callanhan R., Gros P., McNaughton P.A., et al. Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein. J Biol Chem 271 (1996) 13668-13674