Determination of lovastatin in human plasma by ultra-performance liquid chromatography/electrospray ionization tandem mass spectrometry

Biomedical Chromatography

Volumn 22, Issue 5, 2008, Pages 511-518

  Wang, Dong ^a   Wang, Dongmei ^a   Qin, Feng ^a   Chen, Lingyun ^a   Li, Famei ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Human plasma; Lovastatin; Pharmacokinetics; UPLC ESI MS MS

Indexed keywords

DICHLOROMETHANE; ELECTROSPRAY IONIZATION; HEXANE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; ORGANIC SOLVENTS; PLASMA (HUMAN); QUALITY CONTROL;

ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; ESI-MS-MS; HUMAN PLASMAS; LIQUID CHROMATOGRAPHY ELECTROSPRAY; LOVASTATIN; MULTIPLE REACTION MONITORING; SIMVASTATIN; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (UPLC MS/MS); UPLC-ESI-MS/MS;

PHARMACOKINETICS;

2 PROPANOL; ACETONITRILE; AMMONIUM ACETATE; DICHLOROMETHANE; HEXANE; MEVINOLIN; SIMVASTATIN; WATER;

ACCURACY; ANALYTICAL ERROR; AREA UNDER THE CURVE; ARTICLE; CHINESE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG ISOLATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PROCESS DEVELOPMENT; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION PROCESS;

EID: 44249103998     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.962     Document Type: Article

References (18)