Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor

Journal of Pharmacology and Experimental Therapeutics

Volumn 325, Issue 3, 2008, Pages 893-901

  Okamura, Naoe ^a   Habay, Stephen A ^a   Zeng, Joanne ^a   Chamberlin, A Richard ^a   Reinscheid, Rainer K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 OXO 1,1 DIPHENYLTETRAHYDROOXAZOLO[3,4 A]PYRAZINE 7 CARBOXYLIC ACID 4 FLUOROBENZYLAMIDE; 3 OXO 1,1 DIPHENYLTETRAHYDROOXAZOLO[3,4 A]PYRAZINE 7 CARBOXYLIC ACID BENZYLAMIDE; G PROTEIN COUPLED RECEPTOR; NEUROPEPTIDE RECEPTOR; NEUROPEPTIDE S; NEUROPEPTIDE S RECEPTOR; NEUROPEPTIDE S RECEPTOR ANTAGONIST; PIPERAZINE DERIVATIVE; SHA 66; SHA 68;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RECEPTOR BLOCKING; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; NEUROPEPTIDES; OXAZOLIDINONES; PYRAZINES; RECEPTORS, G-PROTEIN-COUPLED;

EID: 44249095333     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.135103     Document Type: Article

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