Transcranial Doppler ultrasonography-directed intravenous glycoprotein IIb/IIIa receptor antagonist therapy to control transient cerebral microemboli before and after carotid endarterectomy

British Journal of Surgery

Volumn 95, Issue 6, 2008, Pages 709-713

  Van Dellen, D ^a   Tiivas, C A S ^a   Jarvi, K ^a   Marshall, C ^a   Higman, D J ^a   Imray, C H E ^a,b  

^a WALSGRAVE HOSPITAL   (United Kingdom)

^b UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBOCYTIC AGENT; DEXTRAN 40; TIROFIBAN; DRUG DERIVATIVE; FIBRINOGEN RECEPTOR; TYROSINE;

ADULT; AGED; BRAIN EMBOLISM; CAROTID ARTERY OBSTRUCTION; CAROTID ENDARTERECTOMY; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; DRUG EFFICACY; FEMALE; HUMAN; MALE; MICROEMBOLISM; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; TREATMENT FAILURE; TREATMENT OUTCOME; ARTICLE; DRUG ANTAGONISM; ENDOSCOPIC ECHOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; METHODOLOGY; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATION; PREOPERATIVE CARE;

AGED; AGED, 80 AND OVER; CAROTID STENOSIS; COMBINED MODALITY THERAPY; ENDARTERECTOMY, CAROTID; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; INTRACRANIAL EMBOLISM; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATIONS; PREOPERATIVE CARE; TYROSINE; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL; ULTRASONOGRAPHY, INTERVENTIONAL;

EID: 44249093027     PISSN: 00071323     EISSN: 13652168     Source Type: Journal    
DOI: 10.1002/bjs.6204     Document Type: Conference Paper

References (31)

1. Johnston DC, Hill MD. The patient with transient cerebral ischemia: a golden opportunity for stroke prevention. CMA J 2004; 170: 1134-1137.
2. Bond R, Rerkasem K, Rothwell PM. Systematic review of the risks of carotid endarterectomy in relation to the clinical indication for and timing of surgery. Stroke 2003; 34: 2290-2301.
3. Siebler M, Nachtmann A, Sitzer M, Rose G, Kleinschmidt A, Rademacher J et al. Cerebral microembolism and the risk of ischemia in asymptomatic high-grade internal carotid artery stenosis. Stroke 1995; 26: 2184-2186.
4. Babikian VL, Wijman CA, Hyde C, Cantelmo NL, Winter MR, Baker E et al. Cerebral microembolism and early recurrent cerebral or retinal ischemic events. Stroke 1997; 28: 1314-1318.
5. Markus HS, MacKinnon A. Asymptomatic embolization detected by Doppler ultrasound predicts stroke risk in symptomatic carotid artery stenosis. Stroke 2005; 36: 971-975.
6. Levi CR, O'Malley HM, Fell G, Roberts AK, Hoare MC, Royle JP et al. Transcranial Doppler detected cerebral microembolism following carotid endarterectomy. High microembolic signal loads predict postoperative cerebral ischaemia. Brain 1997; 120: 621-629.
7. Imray CHE, Tiivas CA. Are some strokes preventable? The potential role of transcranial Doppler in transient ischaemic attacks of carotid origin. Lancet Neurol 2005; 4: 580-586.
8. Sitzer M, Muller W, Siebler M, Hort W, Kniemeyer HW, Jäncke L et al. Plaque ulceration and lumen thrombus are the main sources of cerebral microemboli in high-grade internal carotid artery stenosis. Stroke 1995; 26: 1231-1233.
9. Rothwell PM. Atherothrombosis and ischaemic stroke. BMJ 2007; 334: 379-380.
10. Wallace RC, Furlan AJ, Moliterno DJ, Stevens GH, Masaryk TJ, Perl J II. Basilar artery rethrombosis: successful treatment with platelet glycoprotein Ila/IIIb receptor inhibitor. Am J Neuroradiol 1997; 18: 1257-1260.
11. Rebello SS, Driscoll EM, Lucchesi BR. TP-9201, a glycoprotein Ilb/IIIa platelet receptor antagonist, prevents rethrombosis after successful arterial thrombolysis in the dog. Stroke 1997; 28: 1789-1796.
12. Lennard NS, Vijayasekar C, Tiivas C, Chan CW, Higman DJ, Imray CHE. Control of emboli in patients with recurrent or crescendo transient ischaemic attacks using preoperative transcranial Doppler-directed dextran therapy. Br J Surg 2003; 90: 166-170.
13. Hayes PD, Lloyd AJ, Lennard N, Wolstenholme JL, London NJ, Bell PR et al. Transcranial Doppler-directed dextran-40 therapy is a cost-effective method of preventing carotid thrombosis after carotid endarterectomy. Eur J Vasc Endovasc Surg 2000; 19: 56-61.
14. Naylor AR, Hayes PD, Allroggen H, Lennard N, Gaunt ME, Thompson MM et al. Reducing the risk of carotid surgery: a 7-year audit of the role of monitoring and quality control assessment. J Vasc Surg 2000; 32: 750-759.
15. Krenzelok EP, Parker WA. Dextran 40 anaphylaxis. Anesth Analg 1975; 54: 736-738.
16. Markus HS, Droste DW, Kaps M, Larrue V, Lees KR, Siebler M et al. Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using Doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial. Circulation 2005; 111: 2233-2240.
17. Abumiya T, Fitridge R, Mazur C, Copeland BR, Koziol JA, Tschopp JF et al. Integrin alpha(IIb)beta(3) inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia. Stroke 2000; 31: 1402-1409.
18. Fassbender K, Dempfle CE, Mielke O, Schwartz A, Daffertshofer M, Eschenfelder C et al. Changes in coagulation and fibrinolysis markers in acute ischemic stroke treated with recombinant tissue plasminogen activator. Stroke 1999;30:2101-2104.
19. Junghans U, Siebler M. Cerebral microembolism is blocked by tirofiban, a selective nonpeptide platelet glycoprotein Ilb/IIIa receptor antagonist. Circulation 2003; 107: 2717-2721.
20. Mangiafico S, Cellerini M, Nencini P, Gensini G, Inzitari D. Intravenous glycoprotein Ilb/IIIa inhibitor (tirofiban) followed by intra-arterial urokinase and mechanical thrombolysis in stroke. AJNR Am J Neuroradiol 2005; 26: 2595-2601.
21. Consensus Committee of the Ninth International Cerebral Hemodynamic Symposium. Basic identification criteria of Doppler microembolic signals. Stroke 1995; 26: 1123.
22. Junghans U, Seitz RJ, Aulich A, Freund HJ, Siebler M. Bleeding risk of tirofiban, a nonpeptide GPIIb/TIIa platelet receptor antagonist in progressive stroke: an open pilot study. Cerebrovasc Dis 2001; 12: 308-312.
23. European Carotid Surgery Trialists Collaboration. MRC European Carotid Surgery Trial: interim results for symptomatic patients with severe (70-99%) or with mild (0-29%) carotid stenosis. Lancet 1991; 337: 1235-1243.
24. Rothwell PM, Eliasziw M, Gutnikov SA, Warlow CP, Barnett HJ. Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet 2004; 363: 915-924.
25. Gertler JP, Blankensteijn JD, Brewster DC, Moncure AC, Cambria RP, LaMuraglia GM et al. Carotid endarterectomy for unstable and compelling neurologic conditions: do results justify an aggressive approach? J Vasc Surg 1994; 19: 32-40.
26. Vorchheimer DA, Badimon JJ, Fuster V. Platelet glycoprotein Ilb/IIIa receptor antagonists in cardiovascular disease. JAMA 1999; 281: 1407-1414.
27. McClellan KJ, Goa KL. Tirofiban. A review of its use in acute coronary syndromes. Drugs 1998; 56: 1067-1080.
28. Goertler M, Baeumer M, Kross R, Blaser T, Lutze G, Jost S et al. Rapid decline of cerebral microemboli of arterial origin after intravenous acetylsalicylic acid. Stroke 1999; 30: 66-69.
29. Koster A, Kukucka M, Bach F, Meyer O, Fischer T, Mertzlufft F et al. Anticoagulation during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II and renal impairment using heparin and the platelet glycoprotein IIb - IIIa antagonist tirofiban. Anesthesiology 2001;94:245-251.
30. Calais P, Bock K, Herrlinger JD, Schommer B, Schroder J. [Lysis of an extensive thrombus in the internal carotid artery using a glycoprotein Ilb/IIIa receptor antagonist.] Dtsch Med Wochenschr 2001; 126: 680-683.
31. Karkos CD, McMahon G, McCarthy MJ, Dennis MJ, Sayers RD, London NJM et al. The value of urgent carotid surgery for crescendo transient ischemic attacks. J Vasc Surg 2007; 45: 1148-1154.