The methyl methanesulfonate induced S-phase delay in XRCC1-deficient cells requires ATM and ATR

DNA Repair

Volumn 7, Issue 6, 2008, Pages 849-857

  Brem, Reto ^a   Fernet, Marie ^b   Chapot, Brigitte ^a   Hall, Janet ^a,b  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^b INSERM U612   (France)

Author keywords

ATM; ATR; Base excision repair; Methyl methanesulfonate; Recombinational repair; S phase checkpoint; XRCC1

Indexed keywords

2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE 1; MESYLIC ACID METHYL ESTER; RAD51 PROTEIN; RNA INDUCED SILENCING COMPLEX; XRCC1 PROTEIN;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA RECOMBINATION; DNA STRAND BREAKAGE; EXCISION REPAIR; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HYPOTHESIS; IMMUNOBLOTTING; PRIORITY JOURNAL;

CELL CYCLE PROTEINS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; METHYL METHANESULFONATE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; S PHASE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 44149126949     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2008.02.002     Document Type: Article

References (58)

1. Caldecott K.W. XRCC1 and DNA strand break repair. DNA Repair (Amst.) 2 (2003) 955-969
2. Fan J., and Wilson III D.M. Protein-protein interactions and posttranslational modifications in mammalian base excision repair. Free Radic. Biol. Med. 38 (2005) 1121-1138
3. Lindahl T. Instability and decay of the primary structure of DNA. Nature 362 (1993) 709-715
4. Lindahl T., and Wood R.D. Quality control by DNA repair. Science 286 (1999) 1897-1905
5. Brem R., and Hall J. XRCC1 is required for DNA single-strand break repair in human cells. Nucleic Acids Res. 33 (2005) 2512-2520
6. Dantzer F., Schreiber V., Niedergang C., Trucco C., Flatter E., De La Rubia G., Oliver J., Rolli V., Menissier-de Murcia J., and de Murcia G. Involvement of poly(ADP-ribose) polymerase in base excision repair. Biochimie 81 (1999) 69-75
7. Thompson L.H., Brookman K.W., Dillehay L.E., Carrano A.V., Mazrimas J.A., Mooney C.L., and Minkler J.L. A CHO-cell strain having hypersensitivity to mutagens, a defect in DNA strand-break repair, and an extraordinary baseline frequency of sister-chromatid exchange. Mutat. Res. 95 (1982) 427-440
8. Carrano A.V., Minkler J.L., Dillehay L.E., and Thompson L.H. Incorporated bromodeoxyuridine enhances the sister-chromatid exchange and chromosomal aberration frequencies in an EMS-sensitive Chinese hamster cell line. Mutat. Res. 162 (1986) 233-239
9. Kuzminov A. DNA replication meets genetic exchange: chromosomal damage and its repair by homologous recombination. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 8461-8468
10. Pascucci B., Russo M.T., Crescenzi M., Bignami M., and Dogliotti E. The accumulation of MMS-induced single strand breaks in G1 phase is recombinogenic in DNA polymerase beta defective mammalian cells. Nucleic Acids Res. 33 (2005) 280-288
11. Sobol R.W., Kartalou M., Almeida K.H., Joyce D.F., Engelward B.P., Horton J.K., Prasad R., Samson L.D., and Wilson S.H. Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. J. Biol. Chem. 278 (2003) 39951-39959
12. Helleday T. Pathways for mitotic homologous recombination in mammalian cells. Mutat. Res. 532 (2003) 103-115
13. Tebbs R.S., Flannery M.L., Meneses J.J., Hartmann A., Tucker J.D., Thompson L.H., Cleaver J.E., and Pedersen R.A. Requirement for the Xrcc1 DNA base excision repair gene during early mouse development. Dev. Biol. 208 (1999) 513-529
14. Thompson L.H., Brookman K.W., Jones N.J., Allen S.A., and Carrano A.V. Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange. Mol. Cell Biol. 10 (1990) 6160-6171
15. Horton J.K., Stefanick D.F., Naron J.M., Kedar P.S., and Wilson S.H. Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure. J. Biol. Chem. 280 (2005) 15773-15785
16. Abraham R.T. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15 (2001) 2177-2196
17. Cortez D., Guntuku S., Qin J., and Elledge S.J. ATR and ATRIP: partners in checkpoint signaling. Science 294 (2001) 1713-1716
18. Lee J.H., and Paull T.T. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308 (2005) 551-554
19. Shechter D., Costanzo V., and Gautier J. Regulation of DNA replication by ATR: signaling in response to DNA intermediates. DNA Repair (Amst.) 3 (2004) 901-908
20. Zou L., and Elledge S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300 (2003) 1542-1548
21. Barfknecht T.R., and Little J.B. Hypersensitivity of ataxia telangiectasia skin fibroblasts to DNA alkylating agents. Mutat. Res. 94 (1982) 369-382
22. Cliby W.A., Roberts C.J., Cimprich K.A., Stringer C.M., Lamb J.R., Schreiber S.L., and Friend S.H. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 17 (1998) 159-169
23. Cuadrado M., Martinez-Pastor B., Murga M., Toledo L.I., Gutierrez-Martinez P., Lopez E., and Fernandez-Capetillo O. ATM regulates ATR chromatin loading in response to DNA double-strand breaks. J. Exp. Med. 203 (2006) 297-303
24. Myers J.S., and Cortez D. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J. Biol. Chem. 281 (2006) 9346-9350
25. Stiff T., Walker S.A., Cerosaletti K., Goodarzi A.A., Petermann E., Concannon P., O'Driscoll M., and Jeggo P.A. ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J. 25 (2006) 5775-5782
26. Bolderson E., Scorah J., Helleday T., Smythe C., and Meuth M. ATM is required for the cellular response to thymidine induced replication fork stress. Hum. Mol. Genet. 13 (2004) 2937-2945
27. Kim S.T., Xu B., and Kastan M.B. Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev. 16 (2002) 560-570
28. Musio A., Montagna C., Mariani T., Tilenni M., Focarelli M.L., Brait L., Indino E., Benedetti P.A., Chessa L., Albertini A., et al. SMC1 involvement in fragile site expression. Hum. Mol. Genet. 14 (2005) 525-533
29. Yazdi P.T., Wang Y., Zhao S., Patel N., Lee E.Y., and Qin J. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev. 16 (2002) 571-582
30. Bartek J., Lukas C., and Lukas J. Checking on DNA damage in S phase. Nat. Rev. Mol. Cell Biol. 5 (2004) 792-804
31. Weiss R.S., Matsuoka S., Elledge S.J., and Leder P. Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Curr. Biol. 12 (2002) 73-77
32. You Z., Kong L., and Newport J. The role of single-stranded DNA and polymerase alpha in establishing the ATR, Hus1 DNA replication checkpoint. J. Biol. Chem. 277 (2002) 27088-27093
33. Zou L., Cortez D., and Elledge S.J. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 16 (2002) 198-208
34. Bao S., Tibbetts R.S., Brumbaugh K.M., Fang Y., Richardson D.A., Ali A., Chen S.M., Abraham R.T., and Wang X.F. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature 411 (2001) 969-974
35. Jongmans W., Vuillaume M., Chrzanowska K., Smeets D., Sperling K., and Hall J. Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation. Mol. Cell Biol. 17 (1997) 5016-5022
36. Alderton G.K., Joenje H., Varon R., Borglum A.D., Jeggo P.A., and O'Driscoll M. Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway. Hum. Mol. Genet. 13 (2004) 3127-3138
37. Fernet M., Gribaa M., Salih M.A., Seidahmed M.Z., Hall J., and Koenig M. Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder. Hum. Mol. Genet. 14 (2005) 307-318
38. Renno T., Hahne M., and MacDonald H.R. Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo. J. Exp. Med. 181 (1995) 2283-2287
39. Hickson I., Zhao Y., Richardson C.J., Green S.J., Martin N.M., Orr A.I., Reaper P.M., Jackson S.P., Curtin N.J., and Smith G.C. Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res. 64 (2004) 9152-9159
40. Xu B., Kim S.T., Lim D.S., and Kastan M.B. Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Mol. Cell Biol. 22 (2002) 1049-1059
41. Hurley P.J., and Bunz F. ATM and ATR: components of an integrated circuit. Cell Cycle 6 (2007) 414-417
42. Bryant H.E., and Helleday T. Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair. Nucleic Acids Res. 34 (2006) 1685-1691
43. Kaina B. Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go. Cytogenet. Genome Res. 104 (2004) 77-86
44. Michel B., Flores M.J., Viguera E., Grompone G., Seigneur M., and Bidnenko V. Rescue of arrested replication forks by homologous recombination. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 8181-8188
45. Yokoyama M., Inoue H., Ishii C., and Murakami Y. The novel gene mus7(+) is involved in the repair of replication-associated DNA damage in fission yeast. DNA Repair (Amst.) 6 (2007) 770-780
46. Larson K., Sahm J., Shenkar R., and Strauss B. Methylation-induced blocks to in vitro DNA replication. Mutat. Res. 150 (1985) 77-84
47. Nagelhus T.A., Haug T., Singh K.K., Keshav K.F., Skorpen F., Otterlei M., Bharati S., Lindmo T., Benichou S., Benarous R., et al. A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A. J. Biol. Chem. 272 (1997) 6561-6566
48. Ranalli T.A., DeMott M.S., and Bambara R.A. Mechanism underlying replication protein a stimulation of DNA ligase I. J. Biol. Chem. 277 (2002) 1719-1727
49. Umezu K., Sugawara N., Chen C., Haber J.E., and Kolodner R.D. Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism. Genetics 148 (1998) 989-1005
50. Parlanti E., Locatelli G., Maga G., and Dogliotti E. Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins. Nucleic Acids Res. 35 (2007) 1569-1577
51. Jazayeri A., Falck J., Lukas C., Bartek J., Smith G.C., Lukas J., and Jackson S.P. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol. 8 (2006) 37-45
52. Ray J.H., Altenburg L.C., and Jacobs M.M. Effect of sodium selenite and methyl methanesulfonate or N-hydroxy-2-acetylaminofluorene co-exposure on sister-chromatid exchange production in human whole blood cultures. Mutat. Res. 57 (1978) 359-368
53. Wang Z.Q., Stingl L., Morrison C., Jantsch M., Los M., Schulze-Osthoff K., and Wagner E.F. PARP is important for genomic stability but dispensable in apoptosis. Genes Dev. 11 (1997) 2347-2358
54. Au W.W., and Henderson B.R. Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage. Cell Signal. 19 (2007) 1879-1892
55. Tarsounas M., Davies D., and West S.C. BRCA2-dependent and independent formation of RAD51 nuclear foci. Oncogene 22 (2003) 1115-1123
56. Stokes M.P., Van Hatten R., Lindsay H.D., and Michael W.M. DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. J. Cell Biol. 158 (2002) 863-872
57. Tercero J.A., Longhese M.P., and Diffley J.F. A central role for DNA replication forks in checkpoint activation and response. Mol. Cell 11 (2003) 1323-1336
58. Horton J.K., Stefanick D.F., Kedar P.S., and Wilson S.H. ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity. DNA Repair (Amst.) 6 (2007) 742-750