Antitumor effects of saponin extract from Patrinia villosa (Thunb.) Juss on mice bearing U14 cervical cancer

Phytotherapy Research

Volumn 22, Issue 5, 2008, Pages 640-645

  Zhang, Tao ^a,d   Li, Qingwang ^b,c,f   Li, Kun ^b,d   Li, Yurong ^a   Li, Jian ^b   Wang, Guijie ^d,e   Zhou, Shaobo ^e  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b YANSHAN UNIVERSITY   (China)

^c NORTHWEST A F UNIVERSITY   (China)

^d JIAMUSI UNIVERSITY   (China)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f NONE   (China)

Author keywords

Bcl 2 protein apoptosis; Cervical cancer; Patrinia villosa (Thunb.) Juss; PCNA; Saponin

Indexed keywords

CELL NUCLEUS ANTIGEN; CYCLINE; CYCLOPHOSPHAMIDE; PROTEIN BCL 2; PROTEIN P53; SAPONIN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN U14; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; HUMAN; HUMAN CELL; LOW DRUG DOSE; MEDICINAL PLANT; MOUSE; NONHUMAN; PATRINIA VILLOSA; TUMOR CELL; UTERINE CERVIX CANCER;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL NUCLEUS; FEMALE; IMMUNOHISTOCHEMISTRY; KIDNEY; LIVER; MICE; MUTANT PROTEINS; PATRINIA; PHYTOTHERAPY; PLANT EXTRACTS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS C-BCL-2; SAPONINS; TUMOR SUPPRESSOR PROTEIN P53; UTERINE CERVICAL NEOPLASMS;

MUS; PATRINIA VILLOSA;

EID: 44149123789     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2354     Document Type: Article

References (23)

1. Chang H, But P. 1987. Pharmacology and Applications of Chinese Materia Medica. Vol. 2. World Scientific: Teaneck, NJ, 790-792.
2. Chen B. 2002. The high value of functional effects of white flower Patrinia villosa (Thunb.) Juss. J Plant 6: 15.
3. Chiu LC, Ho TS, Wong EY, Ooi VE. 2006. Ethyl acetate extract of Patrinia scabiosaefolia downregulates anti-apoptotic Bcl-2/ Bcl-X(L) expression, and induces apoptosis in human breast carcinoma MCF-7 cells independent of caspase-9 activation. J Ethnopharmacol 105: 263-268.
4. Dharmananda S. 1997. The treatment of gastro-intestinal cancers with Chinese medicine. http://www.itmonline.org/arts/gicancer.htm.
5. Hsu H, Chen Y, Shen S, Hsu C, Chen C, Chang H. 1986. Oriental Materia Medica. Oriental Healing Arts Institute: Long Beach, CA, 238-239.
6. Huang J, Huang Z. 1994. Research progress on the Proliferating Cell Nuclear Antigen. Abroad Med Sci Physiol Pathol Fascicle 14: 9-11.
7. Ju HK, Baek SH, An RB et al. 2003a. Inhibitory effects of nardostachin on nitric oxide, prostaglandin E2, and tumor necrosis factor-alpha production in lipopolysaccharide activated macrophages. Biol Pharm Bull 26: 1375-1378.
8. Ju HK, Moon TC, Lee E et al. 2003b. Inhibitory effects of a new iridoid, patridoid II and its isomers, on nitric oxide and TNF-alpha production in cultured murine macrophages. Planta Med 69: 950-953.
9. Liu C, Peng M. 1994. Dictionary of Anticancer Herbal Medicine. Hubei Science Publishing Company: Wuhan, 624.
10. Makin G, Dive C. 2001. Apoptosis and cancer chemotherapy. Trends Cell Biol 11: S22-S26.
11. Mao J, Wang L, Zhang M. 2004. Study of anti-tumor of Patrinia scabiosaefolia Fisch extract. Heilongjiang Med Sci 27: 35-38.
12. McLaughlin F, Finn P, La Thangue NB. 2003. The cell cycle, chromatin and cancer: mechanism-based therapeutics come of age. Drug Discov Today 8: 793-802.
13. Reed JC. 1995. Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. Curr Opin Oncol 7: 541-546.
14. Sun SY, Hail N, Jr, Lotan R. 2004. Apoptosis as a novel target for cancer chemoprevention. J Natl Cancer Inst 96: 662-672.
15. Takasaki Y, Fishwild D, Tan EM. 1984. Characterization of proliferating cell nuclear antigen recognized by autoantibodies in lupus sera. J Exp Med 159: 981-992.
16. Vogelstein B, Lane D, Levine AJ. 2000. Surfing the p53 network. Nature 408: 307-310.
17. Wei Y. 1996. The progress of research on PCNA and tumor. Abroad Med Sci Oncol Fascicle 23(s): 47-49.
18. Xu D, Wu Q, Yang Y. 2003. Anti-tumor and Mechanism of Astragali total glycosides. Chin Pharmacol Bull 19: 823-826.
19. Xu J, Zhou F, Jiang F. 2005. Study of saponin from Patrinia villosa (Thunb.) Juss extract technology. J Shandong Chin Med Univ 29: 227-229.
20. Yang Y, Li CC, Weissman AM. 2004. Regulating the p53 system through ubiquitination. Oncogene 23: 2096-2106.
21. Zhang J. 1997. Natural Medicinal Chemistry. The People Health Publisher Company: Beijing, 106.
22. Zheng M. 1990. Experimental study of 472 herbs with antiviral action against the herpes simplex virus. Zhong Xi Yi Jie He Za Zhi 10: 39-41, 6.
23. Zuoteng Z. 1979. Study of anti-tumor crude drug. Dongyang Med 7: 12.